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Accueil Tous les numéros Volume 42 / Numéro 6-7 (Juin-Juillet 2026) Med Sci (Paris), 42 6-7 (2026) 608-615 References
Open Access
Issue
Med Sci (Paris)
Volume 42, Number 6-7, Juin-Juillet 2026
Page(s) 608 - 615
Section Prix Nobel
DOI https://doi.org/10.1051/medsci/2026109
Published online 17 juillet 2026
  1. Glick B, Chang T, Jaap G. The bursa of Fabricius and antibody production. Poultry Science 1956 : 224–5. [Google Scholar]
  2. Miller JF. The golden anniversary of the thymus. Nat Rev Immunol 2011; 11 : 489–95. [Google Scholar]
  3. Gershon RK, Kondo K. Cell interactions in the induction of tolerance: the role of thymic lymphocytes. Immunology 1970 ; 18 : 723–37. [Google Scholar]
  4. Zinkernagel RM, Doherty PC. Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature 1974 ; 248 : 701–2. [Google Scholar]
  5. Kronenberg M, Steinmetz M, Kobori J, et al. RNA transcripts for I-J polypeptides are apparently not encoded between the I-A and I-E subregions of the murine major histocompatibility complex. Proc Natl Acad Sci USA 1983 ; 80 : 5704–8. [Google Scholar]
  6. Meuer SC, Schlossman SF, Reinherz EL. Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions. Proc Natl Acad Sci USA 1982 ; 79 : 4395–9. [Google Scholar]
  7. Swain SL. T cell subsets and the recognition of MHC class. Immunol Rev 1983 ; 74 : 129–42. [Google Scholar]
  8. Kojima A, Prehn RT. Genetic susceptibility to post-thymectomy autoimmune diseases in mice. Immunogenetics 1981 ; 14 : 15–27. [Google Scholar]
  9. Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995 ; 155 : 1151–64. [Google Scholar]
  10. Thornton AM, Shevach EM. CD4+ CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 1998 ; 188 : 287–96. [Google Scholar]
  11. Read S, Malmström V, Powrie F. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25+ CD4+ regulatory cells that control intestinal inflammation. J Exp Med 2000 ; 192 : 295–302. [Google Scholar]
  12. Brunkow ME, Jeffery EW, Hjerrild KA, et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 2001 ; 27 : 68–73. [Google Scholar]
  13. Bennett CL, Christie J, Ramsdell F, et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet 2001 ; 27 : 20–1. [Google Scholar]
  14. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003 ; 299 : 1057–61. [Google Scholar]
  15. Salomon B, Lenschow DJ, Rhee L, et al. B7/CD28 costimulation is essential for the homeostasis of the CD4+ CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity 2000 ; 12 : 431–40. [Google Scholar]
  16. Fisson S, Darrasse-Jèze G, Litvinova E, et al. Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state. J Exp Med 2003 ; 198 : 737–46. [Google Scholar]
  17. Fisson S, Djelti F, Trenado A, et al. Therapeutic potential of self-antigen-specific CD4+ CD25+ regulatory T cells selected in vitro from a polyclonal repertoire. Eur J Immunol 2006 ; 36 : 817–27. [Google Scholar]
  18. Billiard F, Litvinova E, Saadoun D, et al. Regulatory and effector T cell activation levels are prime determinants of in vivo immune regulation. J Immunol 2006 ; 177 : 2167–74. [Google Scholar]
  19. Grinberg-Bleyer Y, Saadoun D, Baeyens A, et al. Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs. J Clin Invest 2010 ; 120 : 4558–68. [Google Scholar]
  20. Cohen JL, Trenado A, Vasey D, et al. CD4+ CD25+ immunoregulatory T Cells: new therapeutics for graft-versus-host disease. J Exp Med 2002 ; 196 : 401–6. [Google Scholar]
  21. Trenado A, Charlotte F, Fisson S, et al. Recipient-type specific CD4+ CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia. J Clin Invest 2003 ; 112 : 1688–96. [Google Scholar]
  22. Darrasse-Jèze G, Bergot AS, Durgeau A, et al. Tumor emergence is sensed by self-specific CD44hi memory Tregs that create a dominant tolerogenic environment for tumors in mice. J Clin Invest 2009 ; 119 : 2648–62. [Google Scholar]
  23. Terrada C, Fisson S, De Kozak Y, et al. Regulatory T cells control uveoretinitis induced by pathogenic Th1 cells reacting to a specific retinal neoantigen. J Immunol 2006 ; 176 : 7171–9. [Google Scholar]
  24. Allenbach Y, Solly S, Grégoire S, et al. Role of regulatory T cells in a new mouse model of experimental autoimmune myositis. Am J Pathol 2009 ; 174 : 989–98. [Google Scholar]
  25. Darrasse-Jèze G, Klatzmann D, Charlotte F, et al. CD4+ CD25+ regulatory/suppressor T cells prevent allogeneic fetus rejection in mice. Immunol Lett 2006 ; 102 : 106–9. [Google Scholar]
  26. Darrasse-Jèze G, Marodon G, Salomon BL, et al. Ontogeny of CD4+ CD25+ regulatory/suppressor T cells in human fetuses. Blood 2005 ; 105 : 4715–21. [Google Scholar]
  27. Grinberg-Bleyer Y, Baeyens A, You S, et al. IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells. J Exp Med 2010 ; 207 : 1871–8. [Google Scholar]
  28. Ait-Oufella H, Salomon BL, Potteaux S, et al. Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med 2006 ; 12 : 178–80. [Google Scholar]
  29. Ephrem A, Chamat S, Miquel C, et al. Expansion of CD4+ CD25+ regulatory T cells by intravenous immunoglobulin: a critical factor in controlling experimental autoimmune encephalomyelitis. Blood 2008 ; 111 : 715–22. [Google Scholar]
  30. Guillot-Delost M, Cheraï M, Hamel Y, et al. Clinical-grade preparation of human natural regulatory T-cells encoding the thymidine kinase suicide gene as a safety gene. J Gene Med 2008 ; 10 : 834–46. [Google Scholar]
  31. Maury S, Lemoine FM, Hicheri Y, et al. CD4+ CD25+ regulatory T cell depletion improves the graft-versus-tumor effect of donor lymphocytes after allogeneic hematopoietic stem cell transplantation. Sci Transl Med 2010 ; 2 : 41ra52. [Google Scholar]
  32. Sawitzki B, Harden PN, Reinke P, et al. Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials. Lancet 2020 ; 395 : 1627–39. [Google Scholar]

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