Coupe le cordon, vole de tes propres ailes !

Erwan Mortier; Fella Tamzalit; Yannick Jacques; Sébastien Morisseau

doi:10.1051/medsci/20143010006

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Volume 30 / Numéro 10 (Octobre 2014)

Med Sci (Paris), 30 10 (2014) 836-838

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Numéro		Med Sci (Paris) Volume 30, Numéro 10, Octobre 2014


Page(s)		836 - 838
Section		Nouvelles
DOI		https://doi.org/10.1051/medsci/20143010006
Publié en ligne		14 octobre 2014

Kobayashi H, Dubois S, Sato N, et al. Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance. Blood 2005 ; 105 : 721–727. [CrossRef] [PubMed] [Google Scholar]
Cheever MA. Twelve Immunotherapy drugs that could cure cancer. Immunol Rev 2008 ; 222 : 357–368. [CrossRef] [PubMed] [Google Scholar]
Grabstein KH, Eisenman J, Shanebeck K, et al. Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science 1994 ; 264 : 965–968. [CrossRef] [PubMed] [Google Scholar]
Giri JG, Kumaki S, Ahdieh M, et al. Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J 1995 ; 14 : 3654–3663. [PubMed] [Google Scholar]
Mortier E, Woo T, Advincula R, et al. IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation. J Exp Med 2008 ; 205 : 1213–1225. [CrossRef] [PubMed] [Google Scholar]
Dubois S, Mariner J, Waldmann TA, et al. IL-15Ralpha recycles and presents IL-15 in trans to neighboring cells. Immunity 2002 ; 17 : 537–547. [CrossRef] [PubMed] [Google Scholar]
Burkett PR, Koka R, Chien M, et al. Coordinate expression and trans presentation of interleukin (IL)-15Ralpha and IL-15 supports natural killer cell and memory CD8+ T cell homeostasis. J Exp Med 2004 ; 200 : 825–834. [CrossRef] [PubMed] [Google Scholar]
Mortier E, Bernard J, Plet A, et al. Natural, proteolytic release of a soluble form of human IL-15 receptor alpha-chain that behaves as a specific, high affinity IL-15 antagonist. J Immunol 2004 ; 173 : 1681–1688. [CrossRef] [PubMed] [Google Scholar]
Mortier E, Quéméner A, Vusio P, et al. Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 × IL-15R alpha fusion proteins. J Biol Chem 2004 ; 281 : 1612–1619. [CrossRef] [PubMed] [Google Scholar]
Tamzalit F, Barbieux I, Plet A, et al. IL-15.IL-15Ra complex shedding following trans-presentation is essential for the survival of IL-15 responding NK and T cells. Proc Natl Acad Sci USA 2014 ; 111 : 8565–8570. [CrossRef] [Google Scholar]
Bouchet J, Alcover A. La synapse immunologique : une plate-forme de signalisation dynamique pour l’activation des lymphocytes T. Med Sci (Paris) 2014 ; 30 : 665–670. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]

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[1] Kobayashi H, Dubois S, Sato N, et al. Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance. Blood 2005 ; 105 : 721–727. [CrossRef] [PubMed] [Google Scholar]

[2] Cheever MA. Twelve Immunotherapy drugs that could cure cancer. Immunol Rev 2008 ; 222 : 357–368. [CrossRef] [PubMed] [Google Scholar]

[3] Grabstein KH, Eisenman J, Shanebeck K, et al. Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science 1994 ; 264 : 965–968. [CrossRef] [PubMed] [Google Scholar]

[4] Giri JG, Kumaki S, Ahdieh M, et al. Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J 1995 ; 14 : 3654–3663. [PubMed] [Google Scholar]

[5] Mortier E, Woo T, Advincula R, et al. IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation. J Exp Med 2008 ; 205 : 1213–1225. [CrossRef] [PubMed] [Google Scholar]

[6] Dubois S, Mariner J, Waldmann TA, et al. IL-15Ralpha recycles and presents IL-15 in trans to neighboring cells. Immunity 2002 ; 17 : 537–547. [CrossRef] [PubMed] [Google Scholar]

[7] Burkett PR, Koka R, Chien M, et al. Coordinate expression and trans presentation of interleukin (IL)-15Ralpha and IL-15 supports natural killer cell and memory CD8+ T cell homeostasis. J Exp Med 2004 ; 200 : 825–834. [CrossRef] [PubMed] [Google Scholar]

[8] Mortier E, Bernard J, Plet A, et al. Natural, proteolytic release of a soluble form of human IL-15 receptor alpha-chain that behaves as a specific, high affinity IL-15 antagonist. J Immunol 2004 ; 173 : 1681–1688. [CrossRef] [PubMed] [Google Scholar]

[9] Mortier E, Quéméner A, Vusio P, et al. Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 × IL-15R alpha fusion proteins. J Biol Chem 2004 ; 281 : 1612–1619. [CrossRef] [PubMed] [Google Scholar]

[10] Tamzalit F, Barbieux I, Plet A, et al. IL-15.IL-15Ra complex shedding following trans-presentation is essential for the survival of IL-15 responding NK and T cells. Proc Natl Acad Sci USA 2014 ; 111 : 8565–8570. [CrossRef] [Google Scholar]

[11] Bouchet J, Alcover A. La synapse immunologique : une plate-forme de signalisation dynamique pour l’activation des lymphocytes T. Med Sci (Paris) 2014 ; 30 : 665–670. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]