Stress du réticulum endoplasmique et apoptose de la cellule bêta dans le diabète - Chronique d’une mort annoncée

Decio L. Eizirik; Isabelle Millard

doi:10.1051/medsci/20143005007

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Volume 30 / Numéro 5 (Mai 2014)

Med Sci (Paris), 30 5 (2014) 496-499

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Numéro		Med Sci (Paris) Volume 30, Numéro 5, Mai 2014


Page(s)		496 - 499
Section		Nouvelles
DOI		https://doi.org/10.1051/medsci/20143005007
Publié en ligne		13 juin 2014

Eizirik DL, Cardozo AK, Cnop M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocrine reviews 2008 ; 29 : 42–61. [CrossRef] [PubMed] [Google Scholar]
Ron D, Harding HP. Protein-folding homeostasis in the endoplasmic reticulum and nutritional regulation. Cold Spring Harbor perspectives in biology 2012 ; 4. [Google Scholar]
Gurzov EN, Eizirik DL. Bcl-2 proteins in diabetes: mitochondrial pathways of beta-cell death and dysfunction. Trends Cell Biol 2011 ; 21 : 424–431. [CrossRef] [PubMed] [Google Scholar]
Engin F, Yermalovich A, Nguyen T, et al. Restoration of the unfolded protein response in pancreatic beta cells protects mice against type 1 diabetes. Sci Transl Med 2013 ; 5 : 211ra156. [CrossRef] [PubMed] [Google Scholar]
Cnop M, Foufelle F, Velloso LA. Endoplasmic reticulum stress, obesity and diabetes. Trends Mol Med 2012 ; 18 : 59–68. [CrossRef] [PubMed] [Google Scholar]
Eizirik DL, Miani M, Cardozo AK. Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation. Diabetologia 2013 ; 56 : 234–241. [CrossRef] [PubMed] [Google Scholar]
Eizirik DL, Colli ML, Ortis F. The role of inflammation in insulitis and beta-cell loss in type 1 diabetes. Nat Rev Endocrinol 2009 ; 5 : 219–226. [CrossRef] [PubMed] [Google Scholar]
Cardozo AK, Ortis F, Storling J, et al. Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2⁺ ATPase 2b and deplete endoplasmic reticulum Ca2⁺, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells. Diabetes 2005 ; 54 : 452–461. [CrossRef] [PubMed] [Google Scholar]
Tersey SA, Nishiki Y, Templin AT, et al. Islet beta-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model. Diabetes 2012 ; 61 : 818–827. [CrossRef] [PubMed] [Google Scholar]
Marhfour I, Lopez XM, Lefkaditis D, et al. Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes. Diabetologia 2012 ; 55 : 2417–2420. [CrossRef] [PubMed] [Google Scholar]
Flamment M, Foufelle F. Le stress du réticulum endoplasmique : de la physiologie à la pathogenèse du diabète de type 2. Med Sci (Paris) 2013 ; 29 : 756–764. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]

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[1] Eizirik DL, Cardozo AK, Cnop M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocrine reviews 2008 ; 29 : 42–61. [CrossRef] [PubMed] [Google Scholar]

[2] Ron D, Harding HP. Protein-folding homeostasis in the endoplasmic reticulum and nutritional regulation. Cold Spring Harbor perspectives in biology 2012 ; 4. [Google Scholar]

[3] Gurzov EN, Eizirik DL. Bcl-2 proteins in diabetes: mitochondrial pathways of beta-cell death and dysfunction. Trends Cell Biol 2011 ; 21 : 424–431. [CrossRef] [PubMed] [Google Scholar]

[4] Engin F, Yermalovich A, Nguyen T, et al. Restoration of the unfolded protein response in pancreatic beta cells protects mice against type 1 diabetes. Sci Transl Med 2013 ; 5 : 211ra156. [CrossRef] [PubMed] [Google Scholar]

[5] Cnop M, Foufelle F, Velloso LA. Endoplasmic reticulum stress, obesity and diabetes. Trends Mol Med 2012 ; 18 : 59–68. [CrossRef] [PubMed] [Google Scholar]

[6] Eizirik DL, Miani M, Cardozo AK. Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation. Diabetologia 2013 ; 56 : 234–241. [CrossRef] [PubMed] [Google Scholar]

[7] Eizirik DL, Colli ML, Ortis F. The role of inflammation in insulitis and beta-cell loss in type 1 diabetes. Nat Rev Endocrinol 2009 ; 5 : 219–226. [CrossRef] [PubMed] [Google Scholar]

[8] Cardozo AK, Ortis F, Storling J, et al. Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2⁺ ATPase 2b and deplete endoplasmic reticulum Ca2⁺, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells. Diabetes 2005 ; 54 : 452–461. [CrossRef] [PubMed] [Google Scholar]

[9] Tersey SA, Nishiki Y, Templin AT, et al. Islet beta-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model. Diabetes 2012 ; 61 : 818–827. [CrossRef] [PubMed] [Google Scholar]

[10] Marhfour I, Lopez XM, Lefkaditis D, et al. Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes. Diabetologia 2012 ; 55 : 2417–2420. [CrossRef] [PubMed] [Google Scholar]

[11] Flamment M, Foufelle F. Le stress du réticulum endoplasmique : de la physiologie à la pathogenèse du diabète de type 2. Med Sci (Paris) 2013 ; 29 : 756–764. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]