Régulation de l’autophagie par la leucine - Sur la piste de la glutamate déshydrogénase

Séverine Lorin

doi:10.1051/medsci/20132910009

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Volume 29 / Numéro 10 (Octobre 2013)

Med Sci (Paris), 29 10 (2013) 839-842

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Numéro		Med Sci (Paris) Volume 29, Numéro 10, Octobre 2013


Page(s)		839 - 842
Section		Nouvelles
DOI		https://doi.org/10.1051/medsci/20132910009
Publié en ligne		18 octobre 2013

Meijer AJ, Codogno P. Autophagy: regulation and role in disease. Crit Rev Clin Lab Sci 2009 ; 46 : 210–240. [CrossRef] [PubMed] [Google Scholar]
Fahien LA, Teller JK, Macdonald MJ, et al. Regulation of glutamate dehydrogenase by Mg²⁺ and magnification of leucine activation by Mg²⁺. Mol Pharmacol 1990 ; 37 : 943–949. [PubMed] [Google Scholar]
Caro LH, Plomp PJ, Leverve XM, et al. A combination of intracellular leucine with either glutamate or aspartate inhibits autophagic proteolysis in isolated rat hepatocytes. Eur J Biochem 1989 ; 181 : 717–720. [CrossRef] [PubMed] [Google Scholar]
Lorin S, Tol MJ, Bauvy C, et al. Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy. Autophagy 2013 ; 9 : 850–860. [CrossRef] [PubMed] [Google Scholar]
Scherz-Shouval R, Shvets E, Fass E, et al. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J 2007 ; 26 : 1749–1760. [CrossRef] [PubMed] [Google Scholar]
Albracht SP, Meijer AJ, Rydstrom J. Mammalian NADH:ubiquinone oxidoreductase (complex I) and nicotinamide nucleotide transhydrogenase (Nnt) together regulate the mitochondrial production of HO-implications for their role in disease, especially cancer. J Bioenerg Biomembr 2011 ; 43 : 541–564. [CrossRef] [PubMed] [Google Scholar]
Duran RV, Oppliger W, Robitaille AM, et al. Glutaminolysis activates Rag-mTORC1 signaling. Mol Cell 2012 ; 47 : 349–358. [CrossRef] [PubMed] [Google Scholar]
Duran RV, Hall MN. Glutaminolysis feeds mTORC1. Cell Cycle 2012 ; 11 : 1–2. [CrossRef] [PubMed] [Google Scholar]
Zoncu R, Bar-Peled L, Efeyan A, Wang S, et al. mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H-ATPase. Science 2011 ; 334 : 678–683. [CrossRef] [PubMed] [Google Scholar]
Han JM, Jeong SJ, Park MC, et al. Leucyl-tRNA Synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell 2012 ; 149 : 410–424. [CrossRef] [PubMed] [Google Scholar]

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[1] Meijer AJ, Codogno P. Autophagy: regulation and role in disease. Crit Rev Clin Lab Sci 2009 ; 46 : 210–240. [CrossRef] [PubMed] [Google Scholar]

[2] Fahien LA, Teller JK, Macdonald MJ, et al. Regulation of glutamate dehydrogenase by Mg²⁺ and magnification of leucine activation by Mg²⁺. Mol Pharmacol 1990 ; 37 : 943–949. [PubMed] [Google Scholar]

[3] Caro LH, Plomp PJ, Leverve XM, et al. A combination of intracellular leucine with either glutamate or aspartate inhibits autophagic proteolysis in isolated rat hepatocytes. Eur J Biochem 1989 ; 181 : 717–720. [CrossRef] [PubMed] [Google Scholar]

[4] Lorin S, Tol MJ, Bauvy C, et al. Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy. Autophagy 2013 ; 9 : 850–860. [CrossRef] [PubMed] [Google Scholar]

[5] Scherz-Shouval R, Shvets E, Fass E, et al. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J 2007 ; 26 : 1749–1760. [CrossRef] [PubMed] [Google Scholar]

[6] Albracht SP, Meijer AJ, Rydstrom J. Mammalian NADH:ubiquinone oxidoreductase (complex I) and nicotinamide nucleotide transhydrogenase (Nnt) together regulate the mitochondrial production of HO-implications for their role in disease, especially cancer. J Bioenerg Biomembr 2011 ; 43 : 541–564. [CrossRef] [PubMed] [Google Scholar]

[7] Duran RV, Oppliger W, Robitaille AM, et al. Glutaminolysis activates Rag-mTORC1 signaling. Mol Cell 2012 ; 47 : 349–358. [CrossRef] [PubMed] [Google Scholar]

[8] Duran RV, Hall MN. Glutaminolysis feeds mTORC1. Cell Cycle 2012 ; 11 : 1–2. [CrossRef] [PubMed] [Google Scholar]

[9] Zoncu R, Bar-Peled L, Efeyan A, Wang S, et al. mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H-ATPase. Science 2011 ; 334 : 678–683. [CrossRef] [PubMed] [Google Scholar]

[10] Han JM, Jeong SJ, Park MC, et al. Leucyl-tRNA Synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell 2012 ; 149 : 410–424. [CrossRef] [PubMed] [Google Scholar]