Accès gratuit
Numéro
Med Sci (Paris)
Volume 28, Numéro 10, Octobre 2012
Page(s) 876 - 882
Section Récepteurs couplés aux protéines G
DOI https://doi.org/10.1051/medsci/20122810017
Publié en ligne 12 octobre 2012
  1. Gloriam DE, Fredriksson R, Schioth HB. The G protein-coupled receptor subset of the rat genome. BMC Genomics 2007 ; 8 : 338. [CrossRef] [PubMed]
  2. DeWire SM, Ahn S, Lefkowitz RJ, Shenoy SK. Beta-arrestins and cell signaling. Annu Rev Physiol 2007 ; 69 : 483–510. [CrossRef] [PubMed]
  3. Kobilka BK, Deupi X. Conformational complexity of G-protein-coupled receptors. Trends Pharmacol Sci 2007 ; 28 : 397–406. [CrossRef] [PubMed]
  4. Dror RO, Arlow DH, Borhani DW, et al. Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observations. Proc Natl Acad Sci USA 2009 ; 106 : 4689–4694. [CrossRef]
  5. Katritch V, Cherezov V, Stevens RC. Diversity and modularity of G protein-coupled receptor structures. Trends Pharmacol Sci 2012 ; 33 : 17–27. [CrossRef] [PubMed]
  6. Deupi X, Standfuss J. Structural insights into agonist-induced activation of G-protein-coupled receptors. Curr Opin Struct Biol 2011 ; 21 : 541–551. [CrossRef] [PubMed]
  7. Kobilka BK. Structural insights into adrenergic receptor function and pharmacology. Trends Pharmacol Sci 2011 ; 32 : 213–218. [CrossRef] [PubMed]
  8. Choe HW, Park JH, Kim YJ, Ernst OP. Transmembrane signaling by GPCRs: insight from rhodopsin and opsin structures. Neuropharmacology 2011 ; 60 : 52–57. [CrossRef] [PubMed]
  9. Rasmussen SG, Choi HJ, Rosenbaum DM, et al. Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. Nature 2007 ; 450 : 383–387. [CrossRef] [PubMed]
  10. Tate CG, Schertler GF. Engineering G protein-coupled receptors to facilitate their structure determination. Curr Opin Struct Biol 2009 ; 19 : 386–395. [CrossRef] [PubMed]
  11. Hanson MA, Cherezov V, Griffith MT, et al. A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor. Structure 2008 ; 16 : 897–905. [CrossRef] [PubMed]
  12. Rosenbaum DM, Cherezov V, Hanson MA, et al. GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function. Science 2007 ; 318 : 1266–1273. [CrossRef] [PubMed]
  13. Cherezov V, Rosenbaum DM, Hanson MA, et al. High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science 2007 ; 318 : 1258–1265. [CrossRef] [PubMed]
  14. Wacker D, Fenalti G, Brown MA, et al. Conserved binding mode of human beta2 adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography. J Am Chem Soc 2010 ; 132 : 11443–11445. [CrossRef] [PubMed]
  15. Jaakola VP, Griffith MT, Hanson MA, et al. The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science 2008 ; 322 : 1211–1217. [CrossRef] [PubMed]
  16. Chien EY, Liu W, Zhao Q, et al. Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist. Science 2010 ; 330 : 1091–1095. [CrossRef] [PubMed]
  17. Shimamura T, Shiroishi M, Weyand S, et al. Structure of the human histamine H1 receptor complex with doxepin. Nature 2011 ; 475 : 65–70. [CrossRef] [PubMed]
  18. Wu B, Chien EY, Mol CD, et al. Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science 2010 ; 330 : 1066–1071. [CrossRef] [PubMed]
  19. Kruse AC, Hu J, Pan AC, et al. Structure and dynamics of the M3 muscarinic acetylcholine receptor. Nature 2012 ; 482 : 552–556. [CrossRef] [PubMed]
  20. Haga K, Kruse AC, Asada H, et al. Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist. Nature 2012 ; 482 : 547–551. [CrossRef] [PubMed]
  21. Hanson MA, Roth CB, Jo E, et al. Crystal structure of a lipid G protein-coupled receptor. Science 2012 ; 335 : 851–855. [CrossRef] [PubMed]
  22. Serrano-Vega MJ, Magnani F, Shibata Y, Tate CG. Conformational thermostabilization of the beta1-adrenergic receptor in a detergent-resistant form. Proc Natl Acad Sci USA 2008 ; 105 : 877–882. [CrossRef]
  23. Shibata Y, White JF, Serrano-Vega MJ, et al. Thermostabilization of the neurotensin receptor NTS1. J Mol Biol 2009 ; 390 : 262–277. [CrossRef] [PubMed]
  24. Magnani F, Shibata Y, Serrano-Vega MJ, Tate CG. Co-evolving stability and conformational homogeneity of the human adenosine A2a receptor. Proc Natl Acad Sci USA 2008 ; 105 : 10744–10749. [CrossRef]
  25. Lebon G, Bennett K, Jazayeri A, Tate CG. Thermostabilisation of an agonist-bound conformation of the human adenosine A(2A) receptor. J Mol Biol 2011 ; 409 : 298–310. [CrossRef] [PubMed]
  26. Warne T, Serrano-Vega MJ, Baker JG, et al. Structure of a beta1-adrenergic G-protein-coupled receptor. Nature 2008 ; 454 : 486–491. [CrossRef] [PubMed]
  27. Dore AS, Robertson N, Errey JC, et al. Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine. Structure 2011 ; 19 : 1283–1293. [CrossRef] [PubMed]
  28. Moukhametzianov R, Warne T, Edwards PC, et al. Two distinct conformations of helix 6 observed in antagonist-bound structures of a beta1-adrenergic receptor. Proc Natl Acad Sci USA 2011 ; 108 : 8228–8232. [CrossRef]
  29. Rasmussen SG, Choi HJ, Fung JJ, et al. Structure of a nanobody-stabilized active state of the beta(2) adrenoceptor. Nature 2011 ; 469 : 175–180. [CrossRef] [PubMed]
  30. Steyaert J, Kobilka BK. Nanobody stabilization of G protein-coupled receptor conformational states. Curr Opin Struct Biol 2011 ; 21 : 567–572. [CrossRef] [PubMed]
  31. Warne T, Moukhametzianov R, Baker JG, et al. The structural basis for agonist and partial agonist action on a beta1-adrenergic receptor. Nature 2011 ; 469 : 241–244. [CrossRef] [PubMed]
  32. Rosenbaum DM, Zhang C, Lyons JA, et al. Structure and function of an irreversible agonist-beta2 adrenoceptor complex. Nature 2011 ; 469 : 236–240. [CrossRef] [PubMed]
  33. Standfuss J, Edwards PC, D’Antona A, et al. The structural basis of agonist-induced activation in constitutively active rhodopsin. Nature 2011 ; 471 : 656–660. [CrossRef] [PubMed]
  34. Choe HW, Kim YJ, Park JH, et al. Crystal structure of metarhodopsin II. Nature 2011 ; 471 : 651–655. [CrossRef] [PubMed]
  35. Scheerer P, Park JH, Hildebrand PW, et al. Crystal structure of opsin in its G-protein-interacting conformation. Nature 2008 ; 455 : 497–502. [CrossRef] [PubMed]
  36. Lebon G, Warne T, Edwards PC, et al. Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation. Nature 2011 ; 474 : 521–525. [CrossRef] [PubMed]
  37. Lebon G, Tate CG. Structure tridimensionnelle du récepteur de l’adénosine A2A lié à son agoniste naturel l’adénosine. Med Sci (Paris) 2011 ; 27 : 926–928. [CrossRef] [EDP Sciences] [PubMed]
  38. Xu F, Wu H, Katritch V, et al. Structure of an agonist-bound human A2A adenosine receptor. Science 2011 ; 332 : 322–327. [CrossRef] [PubMed]
  39. Rasmussen SG, DeVree BT, Zou Y, et al. Crystal structure of the beta2 adrenergic receptor-Gs protein complex. Nature 2011 ; 477 : 549–555. [CrossRef] [PubMed]
  40. Palczewski K, Kumasaka T, Hori T, et al. Crystal structure of rhodopsin: A G protein-coupled receptor. Science 2000 ; 289 : 739–745. [CrossRef] [PubMed]
  41. Fritze O, Filipek S, Kuksa V, et al. Role of the conserved NPxxY(x)5, 6F motif in the rhodopsin ground state and during activation. Proc Natl Acad Sci USA 2003 ; 100 : 2290–2295. [CrossRef]
  42. Granier S. Structure des récepteurs mu et delta des opiacés. Med Sci (Paris) 2012 ; 28 : 870–875. [CrossRef] [EDP Sciences] [PubMed]
  43. Banères JL, Mouillac B. Manipulation des RCPG : expression, purification et stabilisation in vitro. Med Sci (Paris) 2012 ; 28 : 837–844. [CrossRef] [EDP Sciences] [PubMed]

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