Oligomérisation des protéines humaines et virales à sept domaines transmembranaires - Nouvelle stratégie virale pour manipuler la cellule hôte

Ralf Jockers; Florence Gbahou; Kenjiro Tadagaki; Maud Kamal

doi:10.1051/medsci/20122810015

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Volume 28 / Numéro 10 (Octobre 2012)

Med Sci (Paris), 28 10 (2012) 864-869

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Numéro		Med Sci (Paris) Volume 28, Numéro 10, Octobre 2012


Page(s)		864 - 869
Section		Récepteurs couplés aux protéines G
DOI		https://doi.org/10.1051/medsci/20122810015
Publié en ligne		12 octobre 2012

Almen MS, Nordstrom KJ, Fredriksson R, Schioth HB. Mapping the human membrane proteome: a majority of the human membrane proteins can be classified according to function, evolutionary origin. BMC Biol 2009 ; 7 : 50. [CrossRef] [PubMed] [Google Scholar]
Rosenbaum DM, Rasmussen SG, Kobilka BK. The structure and function of G-protein-coupled receptors. Nature 2009 ; 459 : 356–363. [CrossRef] [PubMed] [Google Scholar]
Nordstrom KJ, Sallman Almen M, Edstam MM, et al. Independent HH search, Needleman-Wunsch-based, and motif analyses reveal the overall hierarchy for most of the G protein-coupled receptor families. Mol Biol Evol 2011 ; 28 : 2471–2480. [CrossRef] [PubMed] [Google Scholar]
Gruber CW, Muttenthaler M, Freissmuth M. Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors. Curr Pharm Des 2010 ; 16 : 3071–3088. [CrossRef] [PubMed] [Google Scholar]
Rask-Andersen M, Almen MS, Schioth HB. Trends in the exploitation of novel drug targets. Nat Rev Drug Discov 2011 ; 10 : 579–590. [CrossRef] [PubMed] [Google Scholar]
Levoye A, Jockers R. L’hétérodimérisation des récepteurs couplés aux protéines G : une nouvelle voie vers la découverte de fonctions pour les récepteurs orphelins ? Med Sci (Paris) 2007 ; 23 : 746–750. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
Levoye A, Jockers R. Alternative drug discovery approaches for orphan GPCRs. Drug Discov Today 2008 ; 13 : 52–58. [CrossRef] [PubMed] [Google Scholar]
Levoye A, Dam J, Ayoub MA, et al. Do orphan G-protein-coupled receptors have ligand-independent functions? New insights from receptor heterodimers. EMBO Rep 2006 ; 7 : 1094–1098. [CrossRef] [PubMed] [Google Scholar]
Arrang JM, Morisset S, Gbahou F. Constitutive activity of the histamine H3 receptor. Trends Pharmacol Sci 2007 ; 28 : 350–357. [CrossRef] [PubMed] [Google Scholar]
Milligan G. G protein-coupled receptor hetero-dimerization: contribution to pharmacology and function. Br J Pharmacol 2009 ; 158 : 5–14. [CrossRef] [PubMed] [Google Scholar]
Tadagaki K, Jockers R, Kamal M. History and biological significance of GPCR heteromerization in the neuroendocrine system. Neuroendocrinology 2012 ; 95 : 223–231. [CrossRef] [PubMed] [Google Scholar]
Pin JP, Kniazeff J, Liu J, et al. Allosteric functioning of dimeric class C G-protein-coupled receptors. FEBS J 2005 ; 272 : 2947–2955. [CrossRef] [PubMed] [Google Scholar]
Nelson G, Hoon MA, Chandrashekar J, et al. Mammalian sweet taste receptors. Cell 2001 ; 106 : 381–390. [CrossRef] [PubMed] [Google Scholar]
Nelson G, Chandrashekar J, Hoon MA, et al. An amino-acid taste receptor. Nature 2002 ; 416 : 199–202. [CrossRef] [PubMed] [Google Scholar]
Levoye A, Dam J, Ayoub MA, et al. The orphan GPR50 receptor specifically inhibits MT(1) melatonin receptor function through heterodimerization. EMBO J 2006 ; 25 : 3012–3023. [CrossRef] [PubMed] [Google Scholar]
Slinger E, Langemeijer E, Siderius M, et al. Herpesvirus-encoded GPCRs rewire cellular signaling. Mol Cell Endocrinol 2011 ; 331 : 179–184. [CrossRef] [PubMed] [Google Scholar]
Rosenkilde MM, Smit MJ, Waldhoer M. Structure, function and physiological consequences of virally encoded chemokine seven transmembrane receptors. Br J Pharmacol 2008 ; 153 : S154–S166. [CrossRef] [PubMed] [Google Scholar]
Vischer HF, Nijmeijer S, Smit MJ, Leurs R. Viral hijacking of human receptors through heterodimerization. Biochem Biophys Res Commun 2008 ; 377 : 93–97. [CrossRef] [PubMed] [Google Scholar]
Nijmeijer S, Leurs R, Smit MJ, Vischer HF. The Epstein-Barr virus-encoded G protein-coupled receptor BILF1 hetero-oligomerizes with human CXCR4, scavenges Galphai proteins, and constitutively impairs CXCR4 functioning. J Biol Chem 2010 ; 285 : 29632–29641. [CrossRef] [PubMed] [Google Scholar]
Sharp EL, Davis-Poynter NJ, Farrell HE. Analysis of the subcellular trafficking properties of murine cytomegalovirus M78, a 7 transmembrane receptor homologue. J Gen Virol 2009 ; 90 : 59–68. [CrossRef] [PubMed] [Google Scholar]
Tschische P, Tadagaki K, Kamal M, et al. Heteromerization of human cytomegalovirus encoded chemokine receptors. Biochem Pharmacol 2011 ; 82 : 610–619. [CrossRef] [PubMed] [Google Scholar]
Wagner S, Arnold F, Wu Z, et al. The 7-transmembrane protein homologue UL78 of the human cytomegalovirus forms homomers and traffics between the plasma membrane and different intracellular compartments. Arch Virol 2012 ; 157 : 935–949. [CrossRef] [PubMed] [Google Scholar]
Tadagaki K, Tudor D, Gbahou F, et al. Human cytomegalovirus-encoded UL33 and UL78 heteromerize with host CCR5 and CXCR4 impairing their HIV coreceptor activity. Blood 2012 ; 119 : 4908–4918. [CrossRef] [PubMed] [Google Scholar]
Springael JY, Urizar E, Parmentier M. Dimerization of chemokine receptors and its functional consequences. Cytokine Growth Factor Rev 2005 ; 16 : 611–623. [CrossRef] [PubMed] [Google Scholar]
Lebon G, Tate CG. Les récepteurs couplés aux protéines G dans la lumière. Med Sci (Paris) 2012 ; 28 : 876–882. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
Granier S. Structure des récepteurs mu et delta des opiacés. Med Sci (Paris) 2012 ; 28 : 870–875. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
Combadière B, Combadière C, Deterre P. Les chimiokines : un réseau sophistiqué de guidage cellulaire. Med Sci (Paris) 2007 ; 23 : 173–179. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
Desjardins SF, Berchiche YA, Haddad E, Heveker N. CXCR4, un récepteur de chimiokine aux multiples talents. Med Sci (Paris) 2007 ; 23 : 980–984. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]

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[1] Almen MS, Nordstrom KJ, Fredriksson R, Schioth HB. Mapping the human membrane proteome: a majority of the human membrane proteins can be classified according to function, evolutionary origin. BMC Biol 2009 ; 7 : 50. [CrossRef] [PubMed] [Google Scholar]

[2] Rosenbaum DM, Rasmussen SG, Kobilka BK. The structure and function of G-protein-coupled receptors. Nature 2009 ; 459 : 356–363. [CrossRef] [PubMed] [Google Scholar]

[3] Nordstrom KJ, Sallman Almen M, Edstam MM, et al. Independent HH search, Needleman-Wunsch-based, and motif analyses reveal the overall hierarchy for most of the G protein-coupled receptor families. Mol Biol Evol 2011 ; 28 : 2471–2480. [CrossRef] [PubMed] [Google Scholar]

[4] Gruber CW, Muttenthaler M, Freissmuth M. Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors. Curr Pharm Des 2010 ; 16 : 3071–3088. [CrossRef] [PubMed] [Google Scholar]

[5] Rask-Andersen M, Almen MS, Schioth HB. Trends in the exploitation of novel drug targets. Nat Rev Drug Discov 2011 ; 10 : 579–590. [CrossRef] [PubMed] [Google Scholar]

[6] Levoye A, Jockers R. L’hétérodimérisation des récepteurs couplés aux protéines G : une nouvelle voie vers la découverte de fonctions pour les récepteurs orphelins ? Med Sci (Paris) 2007 ; 23 : 746–750. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]

[7] Levoye A, Jockers R. Alternative drug discovery approaches for orphan GPCRs. Drug Discov Today 2008 ; 13 : 52–58. [CrossRef] [PubMed] [Google Scholar]

[8] Levoye A, Dam J, Ayoub MA, et al. Do orphan G-protein-coupled receptors have ligand-independent functions? New insights from receptor heterodimers. EMBO Rep 2006 ; 7 : 1094–1098. [CrossRef] [PubMed] [Google Scholar]

[9] Arrang JM, Morisset S, Gbahou F. Constitutive activity of the histamine H3 receptor. Trends Pharmacol Sci 2007 ; 28 : 350–357. [CrossRef] [PubMed] [Google Scholar]

[10] Milligan G. G protein-coupled receptor hetero-dimerization: contribution to pharmacology and function. Br J Pharmacol 2009 ; 158 : 5–14. [CrossRef] [PubMed] [Google Scholar]

[11] Tadagaki K, Jockers R, Kamal M. History and biological significance of GPCR heteromerization in the neuroendocrine system. Neuroendocrinology 2012 ; 95 : 223–231. [CrossRef] [PubMed] [Google Scholar]

[12] Pin JP, Kniazeff J, Liu J, et al. Allosteric functioning of dimeric class C G-protein-coupled receptors. FEBS J 2005 ; 272 : 2947–2955. [CrossRef] [PubMed] [Google Scholar]

[13] Nelson G, Hoon MA, Chandrashekar J, et al. Mammalian sweet taste receptors. Cell 2001 ; 106 : 381–390. [CrossRef] [PubMed] [Google Scholar]

[14] Nelson G, Chandrashekar J, Hoon MA, et al. An amino-acid taste receptor. Nature 2002 ; 416 : 199–202. [CrossRef] [PubMed] [Google Scholar]

[15] Levoye A, Dam J, Ayoub MA, et al. The orphan GPR50 receptor specifically inhibits MT(1) melatonin receptor function through heterodimerization. EMBO J 2006 ; 25 : 3012–3023. [CrossRef] [PubMed] [Google Scholar]

[16] Slinger E, Langemeijer E, Siderius M, et al. Herpesvirus-encoded GPCRs rewire cellular signaling. Mol Cell Endocrinol 2011 ; 331 : 179–184. [CrossRef] [PubMed] [Google Scholar]

[17] Rosenkilde MM, Smit MJ, Waldhoer M. Structure, function and physiological consequences of virally encoded chemokine seven transmembrane receptors. Br J Pharmacol 2008 ; 153 : S154–S166. [CrossRef] [PubMed] [Google Scholar]

[18] Vischer HF, Nijmeijer S, Smit MJ, Leurs R. Viral hijacking of human receptors through heterodimerization. Biochem Biophys Res Commun 2008 ; 377 : 93–97. [CrossRef] [PubMed] [Google Scholar]

[19] Nijmeijer S, Leurs R, Smit MJ, Vischer HF. The Epstein-Barr virus-encoded G protein-coupled receptor BILF1 hetero-oligomerizes with human CXCR4, scavenges Galphai proteins, and constitutively impairs CXCR4 functioning. J Biol Chem 2010 ; 285 : 29632–29641. [CrossRef] [PubMed] [Google Scholar]

[20] Sharp EL, Davis-Poynter NJ, Farrell HE. Analysis of the subcellular trafficking properties of murine cytomegalovirus M78, a 7 transmembrane receptor homologue. J Gen Virol 2009 ; 90 : 59–68. [CrossRef] [PubMed] [Google Scholar]

[21] Tschische P, Tadagaki K, Kamal M, et al. Heteromerization of human cytomegalovirus encoded chemokine receptors. Biochem Pharmacol 2011 ; 82 : 610–619. [CrossRef] [PubMed] [Google Scholar]

[22] Wagner S, Arnold F, Wu Z, et al. The 7-transmembrane protein homologue UL78 of the human cytomegalovirus forms homomers and traffics between the plasma membrane and different intracellular compartments. Arch Virol 2012 ; 157 : 935–949. [CrossRef] [PubMed] [Google Scholar]

[23] Tadagaki K, Tudor D, Gbahou F, et al. Human cytomegalovirus-encoded UL33 and UL78 heteromerize with host CCR5 and CXCR4 impairing their HIV coreceptor activity. Blood 2012 ; 119 : 4908–4918. [CrossRef] [PubMed] [Google Scholar]

[24] Springael JY, Urizar E, Parmentier M. Dimerization of chemokine receptors and its functional consequences. Cytokine Growth Factor Rev 2005 ; 16 : 611–623. [CrossRef] [PubMed] [Google Scholar]

[25] Lebon G, Tate CG. Les récepteurs couplés aux protéines G dans la lumière. Med Sci (Paris) 2012 ; 28 : 876–882. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]

[26] Granier S. Structure des récepteurs mu et delta des opiacés. Med Sci (Paris) 2012 ; 28 : 870–875. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]

[27] Combadière B, Combadière C, Deterre P. Les chimiokines : un réseau sophistiqué de guidage cellulaire. Med Sci (Paris) 2007 ; 23 : 173–179. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]

[28] Desjardins SF, Berchiche YA, Haddad E, Heveker N. CXCR4, un récepteur de chimiokine aux multiples talents. Med Sci (Paris) 2007 ; 23 : 980–984. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]