Le xeroderma pigmentosum - Un modèle d’analyse du lien entre accumulation de mutations génomiques et effet Warburg durant la transformation tumorale

Hamid Reza Rezvani; Alain Taïeb

doi:10.1051/medsci/2011275007

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Volume 27 / Numéro 5 (Mai 2011)

Med Sci (Paris), 27 5 (2011) 467-470

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Numéro		Med Sci (Paris) Volume 27, Numéro 5, Mai 2011


Page(s)		467 - 470
Section		Nouvelles
DOI		https://doi.org/10.1051/medsci/2011275007
Publié en ligne		25 mai 2011

Warburg O. On the origin of cancer cells. Science 1956 ; 123 : 309-314. [CrossRef] [PubMed] [Google Scholar]
Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis ? Nat Rev Cancer 2004 ; 4 : 891-899. [CrossRef] [PubMed] [Google Scholar]
Brandon M, Baldi P, Wallace DC. Mitochondrial mutations in cancer. Oncogene 2006 ; 25 : 4647-4662. [CrossRef] [PubMed] [Google Scholar]
Yeung SJ, Pan J, Lee MH. Roles of p53, MYC and HIF-1 in regulating glycolysis: the seventh hallmark of cancer. Cell Mol Life Sci 2008 ; 65 : 3981-3999. [CrossRef] [PubMed] [Google Scholar]
Cleaver JE. Cancer in xeroderma pigmentosum and related disorders of DNA repair. Nat Rev Cancer 2005 ; 5 : 564-573. [CrossRef] [PubMed] [Google Scholar]
Kraemer KH, Lee MM, Scotto J. Xeroderma pigmentosum. Cutaneous, ocular, and neurologic abnormalities in 830 published cases. Arch Dermatol 1987 ; 123 : 241-250. [CrossRef] [PubMed] [Google Scholar]
Miccoli L, Burr KL, Hickenbotham P, et al. The combined effects of xeroderma pigmentosum C deficiency and mutagens on mutation rates in the mouse germ line. Cancer Res 2007 ; 67 : 4695-4699. [CrossRef] [PubMed] [Google Scholar]
Wijnhoven SW, Kool HJ, Mullenders LH, et al. Age-dependent spontaneous mutagenesis in Xpc mice defective in nucleotide excision repair. Oncogene 2000 ; 19 : 5034-5037. [CrossRef] [PubMed] [Google Scholar]
Rezvani HR, Rossignol R, Ali N, et al. XPC silencing in normal human keratinocytes triggers metabolic alterations through NOX-1 activation-mediated reactive oxygen species. Biochim Biophys Acta 2010 ; 5 : décembre (online). [Google Scholar]
Rezvani HR, Kim AL, Rossignol R, et al. XPC silencing in normal human keratinocytes triggers metabolic alterations that drive the formation of squamous cell carcinomas. J Clin Invest 2011 ; 121 : 195-211. [CrossRef] [PubMed] [Google Scholar]
Bozulic L, Surucu B, Hynx D, Hemmings BA. PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival. Mol Cell 2008 ; 30 : 203-213. [CrossRef] [PubMed] [Google Scholar]
Robey RB, Hay N. Is Akt the Warburg kinase ? Akt-energy metabolism interactions and oncogenesis. Semin Cancer Biol 2009 ; 19 : 25-31. [CrossRef] [PubMed] [Google Scholar]
Clerkin JS, Naughton R, Quiney C, Cotter TG. Mechanisms of ROS modulated cell survival during carcinogenesis. Cancer Lett 2008 ; 266 : 30-36. [CrossRef] [PubMed] [Google Scholar]
Migdal C, Serres M. Espèces réactives de l’oxygène et stress oxydant. Med Sci (Paris) 2011 ; 27 : 405-412. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
Compe E, Egly JM. Troubles neurologiques et trichothiodystrophie : sans TFIIH, les hormones thyroïdiennes défaillent. Med Sciv (Paris) 2007 ; 23 : 1171-1172. [CrossRef] [EDP Sciences] [Google Scholar]

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[1] Warburg O. On the origin of cancer cells. Science 1956 ; 123 : 309-314. [CrossRef] [PubMed] [Google Scholar]

[2] Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis ? Nat Rev Cancer 2004 ; 4 : 891-899. [CrossRef] [PubMed] [Google Scholar]

[3] Brandon M, Baldi P, Wallace DC. Mitochondrial mutations in cancer. Oncogene 2006 ; 25 : 4647-4662. [CrossRef] [PubMed] [Google Scholar]

[4] Yeung SJ, Pan J, Lee MH. Roles of p53, MYC and HIF-1 in regulating glycolysis: the seventh hallmark of cancer. Cell Mol Life Sci 2008 ; 65 : 3981-3999. [CrossRef] [PubMed] [Google Scholar]

[5] Cleaver JE. Cancer in xeroderma pigmentosum and related disorders of DNA repair. Nat Rev Cancer 2005 ; 5 : 564-573. [CrossRef] [PubMed] [Google Scholar]

[6] Kraemer KH, Lee MM, Scotto J. Xeroderma pigmentosum. Cutaneous, ocular, and neurologic abnormalities in 830 published cases. Arch Dermatol 1987 ; 123 : 241-250. [CrossRef] [PubMed] [Google Scholar]

[7] Miccoli L, Burr KL, Hickenbotham P, et al. The combined effects of xeroderma pigmentosum C deficiency and mutagens on mutation rates in the mouse germ line. Cancer Res 2007 ; 67 : 4695-4699. [CrossRef] [PubMed] [Google Scholar]

[8] Wijnhoven SW, Kool HJ, Mullenders LH, et al. Age-dependent spontaneous mutagenesis in Xpc mice defective in nucleotide excision repair. Oncogene 2000 ; 19 : 5034-5037. [CrossRef] [PubMed] [Google Scholar]

[9] Rezvani HR, Rossignol R, Ali N, et al. XPC silencing in normal human keratinocytes triggers metabolic alterations through NOX-1 activation-mediated reactive oxygen species. Biochim Biophys Acta 2010 ; 5 : décembre (online). [Google Scholar]

[10] Rezvani HR, Kim AL, Rossignol R, et al. XPC silencing in normal human keratinocytes triggers metabolic alterations that drive the formation of squamous cell carcinomas. J Clin Invest 2011 ; 121 : 195-211. [CrossRef] [PubMed] [Google Scholar]

[11] Bozulic L, Surucu B, Hynx D, Hemmings BA. PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival. Mol Cell 2008 ; 30 : 203-213. [CrossRef] [PubMed] [Google Scholar]

[12] Robey RB, Hay N. Is Akt the Warburg kinase ? Akt-energy metabolism interactions and oncogenesis. Semin Cancer Biol 2009 ; 19 : 25-31. [CrossRef] [PubMed] [Google Scholar]

[13] Clerkin JS, Naughton R, Quiney C, Cotter TG. Mechanisms of ROS modulated cell survival during carcinogenesis. Cancer Lett 2008 ; 266 : 30-36. [CrossRef] [PubMed] [Google Scholar]

[14] Migdal C, Serres M. Espèces réactives de l’oxygène et stress oxydant. Med Sci (Paris) 2011 ; 27 : 405-412. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]

[15] Compe E, Egly JM. Troubles neurologiques et trichothiodystrophie : sans TFIIH, les hormones thyroïdiennes défaillent. Med Sciv (Paris) 2007 ; 23 : 1171-1172. [CrossRef] [EDP Sciences] [Google Scholar]