Activation de caspases et formation de dégénérescences neurofibrillaires dans un modèle murin de la maladie d’Alzheimer

Alix de Calignon; Tara L. Spires-Jones; Bradley T. Hyman

doi:10.1051/medsci/20102610787

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Volume 26 / Numéro 10 (Octobre 2010)

Med Sci (Paris), 26 10 (2010) 787-816

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Numéro		Med Sci (Paris) Volume 26, Numéro 10, Octobre 2010


Page(s)		787 - 816
Section		Nouvelles
DOI		https://doi.org/10.1051/medsci/20102610787
Publié en ligne		15 octobre 2010

Duyckaerts C, Hauw JJ. Diagnosis and staging of Alzheimer disease. Neurobiol Aging 1997; 18 (suppl 4) : S33-42. [Google Scholar]
Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics. Science 2002; 297 : 353-6. [Google Scholar]
Hutton M. Missense and splice site mutations in tau associated with FTDP-17: multiple pathogenic mechanisms. Neurology 2001; 56 (suppl 4) : S21-5. [Google Scholar]
Gomez-Isla T, Hollister R, West H, et al. Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer’s disease. Ann Neurol 1997; 41 : 17-24. [Google Scholar]
Augustinack JC, Schneider A, Mandelkow EM, Hyman BT. Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer’s disease. Acta Neuropathol 2002; 103 : 26-35. [Google Scholar]
Rohn TT, Head E, Nesse WH, et al. Activation of caspase-8 in the Alzheimer’s disease brain. Neurobiol Dis 2001; 8 : 1006-16. [Google Scholar]
Guo H, Albrecht S, Bourdeau M, et al. Active caspase- 6 and caspase-6-cleaved tau in neurophil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer’s disease. Am J Pathol 2004; 165 : 523-31. [Google Scholar]
Santacruz K, Lewis J, Spires T, et al. Tau suppression in a neurodegenerative mouse model improves memory function. Science 2005; 309 : 476-81. [Google Scholar]
Bacskai BJ, Kajdasz ST, Christie RH, et al. Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nat Med 2001; 7 : 369-72. [Google Scholar]
Guntern R, Bouras C, Hof PR, Vallet PG. An improved thioflavine S method for staining neurofibrillary tangles and senile plaques in Alzheimer’s disease. Experientia 1992; 48 : 8-10. [Google Scholar]
Spires-Jones TL, de Calignon A, Matsui T, et al. In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons. J Neurosci 2008; 28 : 862-7. [Google Scholar]
De Calignon A, Spires-Jones TL, Pitstick R, et al. Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy. J Neuropathol Exp Neurol 2009; 68 : 757-61. [Google Scholar]
De Calignon A, Fox LM, Pitstick R, et al. Caspase activation precedes and leads to tangles. Nature 2010; 464 : 1201-4. [Google Scholar]
Clavaguera F, Goedert M, Tolnay M. Induction et propagation de la pathologie par la protéine tau chez un modèle murin de la maladie d’Alzheimer. Med Sci (Paris) 2010; 26 : 121-4. [Google Scholar]

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[1] Duyckaerts C, Hauw JJ. Diagnosis and staging of Alzheimer disease. Neurobiol Aging 1997; 18 (suppl 4) : S33-42. [Google Scholar]

[2] Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics. Science 2002; 297 : 353-6. [Google Scholar]

[3] Hutton M. Missense and splice site mutations in tau associated with FTDP-17: multiple pathogenic mechanisms. Neurology 2001; 56 (suppl 4) : S21-5. [Google Scholar]

[4] Gomez-Isla T, Hollister R, West H, et al. Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer’s disease. Ann Neurol 1997; 41 : 17-24. [Google Scholar]

[5] Augustinack JC, Schneider A, Mandelkow EM, Hyman BT. Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer’s disease. Acta Neuropathol 2002; 103 : 26-35. [Google Scholar]

[6] Rohn TT, Head E, Nesse WH, et al. Activation of caspase-8 in the Alzheimer’s disease brain. Neurobiol Dis 2001; 8 : 1006-16. [Google Scholar]

[7] Guo H, Albrecht S, Bourdeau M, et al. Active caspase- 6 and caspase-6-cleaved tau in neurophil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer’s disease. Am J Pathol 2004; 165 : 523-31. [Google Scholar]

[8] Santacruz K, Lewis J, Spires T, et al. Tau suppression in a neurodegenerative mouse model improves memory function. Science 2005; 309 : 476-81. [Google Scholar]

[9] Bacskai BJ, Kajdasz ST, Christie RH, et al. Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nat Med 2001; 7 : 369-72. [Google Scholar]

[10] Guntern R, Bouras C, Hof PR, Vallet PG. An improved thioflavine S method for staining neurofibrillary tangles and senile plaques in Alzheimer’s disease. Experientia 1992; 48 : 8-10. [Google Scholar]

[11] Spires-Jones TL, de Calignon A, Matsui T, et al. In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons. J Neurosci 2008; 28 : 862-7. [Google Scholar]

[12] De Calignon A, Spires-Jones TL, Pitstick R, et al. Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy. J Neuropathol Exp Neurol 2009; 68 : 757-61. [Google Scholar]

[13] De Calignon A, Fox LM, Pitstick R, et al. Caspase activation precedes and leads to tangles. Nature 2010; 464 : 1201-4. [Google Scholar]

[14] Clavaguera F, Goedert M, Tolnay M. Induction et propagation de la pathologie par la protéine tau chez un modèle murin de la maladie d’Alzheimer. Med Sci (Paris) 2010; 26 : 121-4. [Google Scholar]