FOXL2, le gardien de l’identité ovarienne

Maëlle Pannetier; Eric Pailhoux

doi:10.1051/medsci/2010265470

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Volume 26 / Numéro 5 (Mai 2010)

Med Sci (Paris), 26 5 (2010) 470-473

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Numéro		Med Sci (Paris) Volume 26, Numéro 5, Mai 2010


Page(s)		470 - 473
Section		Nouvelles
DOI		https://doi.org/10.1051/medsci/2010265470
Publié en ligne		15 mai 2010

Uhlenhaut NH, Jakob S, Anlag K, et al. Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. Cell 2009; 139 : 1130–42. [Google Scholar]
Sinclair AH, Berta P, Palmer MS, et al. A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif. Nature 1990; 346 : 240–4. [Google Scholar]
Berta P, Hawkins JR, Sinclair AH, et al. Genetic evidence equating SRY and the testis-determining factor. Nature 1990; 348 : 448–50. [Google Scholar]
Koopman P, Gubbay J, Vivian N, et al. Male development of chromosomally female mice transgenic for Sry. Nature 1991; 351 : 117–21. [Google Scholar]
Vidal VP, Chaboissier MC, de Rooij DG, et al. Sox9 induces testis development in XX transgenic mice. Nat Genet 2001; 28 : 216–7. [Google Scholar]
Qin Y, Bishop CE. Sox9 is sufficient for functional testis development producing fertile male mice in the absence of Sry. Hum Mol Genet 2005; 14 : 1221–9. [Google Scholar]
Sekido R, Lovell-Badge R. Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer. Nature 2008; 453 : 930–4. [Google Scholar]
McElreavey K, Vilain E, Abbas N, et al. A regulatory cascade hypothesis for mammalian sex determination : SRY represses a negative regulator of male development. Proc Natl Acad Sci USA 1993; 90 : 3368–72. [Google Scholar]
Parma P, Radi O, Vidal V, et al R-spondin1 is essential in sex determination, skin differentiation and malignancy. Nat Genet 2006; 38 : 1304–9. [Google Scholar]
Pailhoux E, Vigier B, Chaffaux S, et al. A 11.7-kb deletion triggers intersexuality and polledness in goats. Nat Genet 2001; 29 : 453–8. [Google Scholar]
Pailhoux E, Vigier B, Vaiman D, et al. Ontogenesis of female-to-male sex-reversal in XX polled goats. Dev Dyn 2002; 224 : 39–50. [Google Scholar]
Schmidt D, Ovitt CE, Anlag K, et al. The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance. Development 2004; 131 : 933–42. [Google Scholar]
Uda M, Ottolenghi C, Crisponi L, et al. Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development.Hum Mol Genet 2004; 13 : 1171–81. [Google Scholar]
Pannetier M, Fabre S, Batista F, et al. FOXL2 activates P450 aromatase gene transcription : towards a better characterization of the early steps of mammalian ovarian development. J Mol Endocrinol 2006; 36 : 399–413. [Google Scholar]
Couse JF, Hewitt SC, Bunch DO, et al. Postnatal sex reversal of the ovaries in mice lacking estrogen receptors alpha and beta. Science 1999; 286 : 2328–31. [Google Scholar]
McElreavey K, Vilain E, Abbas N, Herskowitz I, Fellous M. A regulatory cascade hypothesis for mammalian sex determination : SRY represses a negative regulator of male development. Proc Natl Acad Sci USA 1993; 90 : 3368–72. [Google Scholar]

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[1] Uhlenhaut NH, Jakob S, Anlag K, et al. Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. Cell 2009; 139 : 1130–42. [Google Scholar]

[2] Sinclair AH, Berta P, Palmer MS, et al. A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif. Nature 1990; 346 : 240–4. [Google Scholar]

[3] Berta P, Hawkins JR, Sinclair AH, et al. Genetic evidence equating SRY and the testis-determining factor. Nature 1990; 348 : 448–50. [Google Scholar]

[4] Koopman P, Gubbay J, Vivian N, et al. Male development of chromosomally female mice transgenic for Sry. Nature 1991; 351 : 117–21. [Google Scholar]

[5] Vidal VP, Chaboissier MC, de Rooij DG, et al. Sox9 induces testis development in XX transgenic mice. Nat Genet 2001; 28 : 216–7. [Google Scholar]

[6] Qin Y, Bishop CE. Sox9 is sufficient for functional testis development producing fertile male mice in the absence of Sry. Hum Mol Genet 2005; 14 : 1221–9. [Google Scholar]

[7] Sekido R, Lovell-Badge R. Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer. Nature 2008; 453 : 930–4. [Google Scholar]

[8] McElreavey K, Vilain E, Abbas N, et al. A regulatory cascade hypothesis for mammalian sex determination : SRY represses a negative regulator of male development. Proc Natl Acad Sci USA 1993; 90 : 3368–72. [Google Scholar]

[9] Parma P, Radi O, Vidal V, et al R-spondin1 is essential in sex determination, skin differentiation and malignancy. Nat Genet 2006; 38 : 1304–9. [Google Scholar]

[10] Pailhoux E, Vigier B, Chaffaux S, et al. A 11.7-kb deletion triggers intersexuality and polledness in goats. Nat Genet 2001; 29 : 453–8. [Google Scholar]

[11] Pailhoux E, Vigier B, Vaiman D, et al. Ontogenesis of female-to-male sex-reversal in XX polled goats. Dev Dyn 2002; 224 : 39–50. [Google Scholar]

[12] Schmidt D, Ovitt CE, Anlag K, et al. The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance. Development 2004; 131 : 933–42. [Google Scholar]

[13] Uda M, Ottolenghi C, Crisponi L, et al. Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development.Hum Mol Genet 2004; 13 : 1171–81. [Google Scholar]

[14] Pannetier M, Fabre S, Batista F, et al. FOXL2 activates P450 aromatase gene transcription : towards a better characterization of the early steps of mammalian ovarian development. J Mol Endocrinol 2006; 36 : 399–413. [Google Scholar]

[15] Couse JF, Hewitt SC, Bunch DO, et al. Postnatal sex reversal of the ovaries in mice lacking estrogen receptors alpha and beta. Science 1999; 286 : 2328–31. [Google Scholar]

[16] McElreavey K, Vilain E, Abbas N, Herskowitz I, Fellous M. A regulatory cascade hypothesis for mammalian sex determination : SRY represses a negative regulator of male development. Proc Natl Acad Sci USA 1993; 90 : 3368–72. [Google Scholar]