Les bactéries filamenteuses segmentées induisent les cellules Th17 dans l’intestin

Ivaylo I. Ivanov; Nicolas Manel

doi:10.1051/medsci/2010264352

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Volume 26 / Numéro 4 (Avril 2010)

Med Sci (Paris), 26 4 (2010) 352-355

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Numéro		Med Sci (Paris) Volume 26, Numéro 4, Avril 2010


Page(s)		352 - 355
Section		Nouvelles
DOI		https://doi.org/10.1051/medsci/2010264352
Publié en ligne		15 avril 2010

Acosta-Rodriguez EV, Rivino L, Geginat J, et al. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol 2007; 8 : 639–46. [Google Scholar]
Manel N, Unutmaz D, Littman DR. The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol 2008; 9 : 641–9. [Google Scholar]
Volpe E, Servant N, Zollinger R, et al. A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat Immunol 2008; 9 : 650–7. [Google Scholar]
Korn T, Bettelli E, Gao W, et al. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 2007; 448 : 484–7. [Google Scholar]
Veldhoen M, Hocking RJ, Atkins CJ, et al. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006; 24 : 179–89. [Google Scholar]
Bettelli E, Carrier Y, Gao W, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006; 441 : 235–8. [Google Scholar]
Langrish CL, Chen Y, Blumenschein WM, et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 2005; 201 : 233–40. [Google Scholar]
Mangan PR, Harrington LE, O’Quinn DB, et al. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 2006; 441 : 231–4. [Google Scholar]
Nurieva R, Yang XO, Martinez G, et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 2007; 448 : 480–3. [Google Scholar]
Zhou L, Ivanov, II, Spolski R, et al. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 2007; 8 : 967–74. [Google Scholar]
Ivanov, II, McKenzie BS, Zhou L, et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 2006; 126 : 1121–33. [Google Scholar]
Ivanov, II, Zhou L, Littman DR. Transcriptional regulation of Th17 cell differentiation. Semin Immunol 2007; 19 : 409–17. [Google Scholar]
Zhou L, Lopes JE, Chong MM, et al. TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 2008; 453 : 236–40. [Google Scholar]
Ivanov, II, Frutos Rde L, Manel N, et al. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe 2008; 4 : 337–49. [Google Scholar]
Ivanov, II, Atarashi K, Manel N, et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 2009; 139 : 485–98. [Google Scholar]
Salzman NH, Hung K, Haribhai D, et al. Enteric defensins are essential regulators of intestinal microbial ecology. Nat Immunol 2009. [Google Scholar]
Gaboriau-Routhiau V, Rakotobe S, Lecuyer E, et al. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity 2009; 31 : 677–89. [Google Scholar]
Leung-Theung-Long S, Guerder S. Les cellules Th17 : Une nouvelle population de cellules T CD4 effectrices pro-inflammatoires. Med Sci (Paris) 2008; 24 : 972–6. [Google Scholar]
Soumelis V, Volpe E. Différenciation des lymphocytes TH17 : Des souris et des hommes. Med Sci (Paris) 2008; 24 : 925–7. [Google Scholar]
Sendid B, Jouault T, Vitse A, et al. Glycanes pariétaux de levures et anticorps spécifiques : biomarqueurs et outils d’analyse physiopathologique des candidoses et de la maladie de Crohn. Med Sci (Paris) 2009; 25 : 473–81. [Google Scholar]

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[1] Acosta-Rodriguez EV, Rivino L, Geginat J, et al. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol 2007; 8 : 639–46. [Google Scholar]

[2] Manel N, Unutmaz D, Littman DR. The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol 2008; 9 : 641–9. [Google Scholar]

[3] Volpe E, Servant N, Zollinger R, et al. A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat Immunol 2008; 9 : 650–7. [Google Scholar]

[4] Korn T, Bettelli E, Gao W, et al. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 2007; 448 : 484–7. [Google Scholar]

[5] Veldhoen M, Hocking RJ, Atkins CJ, et al. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006; 24 : 179–89. [Google Scholar]

[6] Bettelli E, Carrier Y, Gao W, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006; 441 : 235–8. [Google Scholar]

[7] Langrish CL, Chen Y, Blumenschein WM, et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 2005; 201 : 233–40. [Google Scholar]

[8] Mangan PR, Harrington LE, O’Quinn DB, et al. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 2006; 441 : 231–4. [Google Scholar]

[9] Nurieva R, Yang XO, Martinez G, et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 2007; 448 : 480–3. [Google Scholar]

[10] Zhou L, Ivanov, II, Spolski R, et al. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 2007; 8 : 967–74. [Google Scholar]

[11] Ivanov, II, McKenzie BS, Zhou L, et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 2006; 126 : 1121–33. [Google Scholar]

[12] Ivanov, II, Zhou L, Littman DR. Transcriptional regulation of Th17 cell differentiation. Semin Immunol 2007; 19 : 409–17. [Google Scholar]

[13] Zhou L, Lopes JE, Chong MM, et al. TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 2008; 453 : 236–40. [Google Scholar]

[14] Ivanov, II, Frutos Rde L, Manel N, et al. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe 2008; 4 : 337–49. [Google Scholar]

[15] Ivanov, II, Atarashi K, Manel N, et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 2009; 139 : 485–98. [Google Scholar]

[16] Salzman NH, Hung K, Haribhai D, et al. Enteric defensins are essential regulators of intestinal microbial ecology. Nat Immunol 2009. [Google Scholar]

[17] Gaboriau-Routhiau V, Rakotobe S, Lecuyer E, et al. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity 2009; 31 : 677–89. [Google Scholar]

[18] Leung-Theung-Long S, Guerder S. Les cellules Th17 : Une nouvelle population de cellules T CD4 effectrices pro-inflammatoires. Med Sci (Paris) 2008; 24 : 972–6. [Google Scholar]

[19] Soumelis V, Volpe E. Différenciation des lymphocytes TH17 : Des souris et des hommes. Med Sci (Paris) 2008; 24 : 925–7. [Google Scholar]

[20] Sendid B, Jouault T, Vitse A, et al. Glycanes pariétaux de levures et anticorps spécifiques : biomarqueurs et outils d’analyse physiopathologique des candidoses et de la maladie de Crohn. Med Sci (Paris) 2009; 25 : 473–81. [Google Scholar]