Accès gratuit
Med Sci (Paris)
Volume 25, Numéro 1, Janvier 2009
Page(s) 105 - 110
Section Recherche et partenariat
Publié en ligne 15 janvier 2009
  1. Russel WMS, Burch RL. The principles of human experimental technique (1959). Universities Federation for Animal Welfare (UFAW). Herts, UK : Potters Bar, 1992 (special edition) : 238 p.
  2. Greene N, Judson PN, Langowski JJ, Marchant CA. Knowledge-based expert systems for toxicity and metabolism prediction: DEREK, StAR and METEOR. SAR QSAR Environ Res 1999; 10 : 299–314.
  3. Rosenkranz HS, Cunningham AR, Zhang YP, et al. Development, characterization and application of predictive-toxicology models. SAR QSAR Environ Res 1999; 10 : 277–98.
  4. Hayashi M, Kamata E, Hirose A, et al. In silico assessment of chemical mutagenesis in comparison with results of Salmonella microsome assay on 909 chemicals. Mutat Res 2005; 588 : 129–35.
  5. Lewis A, Kazantis N, Fishtik I, et al. Integrating process safety with molecular modelling-based risk assessment of chemicals within REACH regulatory framework: benefit and future challenges. J Hasard Mat 2007; 142 : 592–602.
  6. Olson H, Betton G, Robinson D, et al. Concordance of the toxicity of pharmaceuticals in humans and in animals. Regul Toxicol Pharmacol 2000; 32 : 56–67.
  7. Guillouzo A. Liver cell models in in vitro toxicology. Environ Health Perspect 1998; 106 (suppl 2) : 511–32.
  8. Hewitt NJ, Lechón MJ, Houston JB, et al. Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.Drug Metab Rev 2007; 39 : 159–234.
  9. Mannello F, Tonti GA. Concise review: no breakthroughs for human mesenchymal and embryonic stem cell culture: conditioned medium, feeder layer, or feeder-free; medium with fetal calf serum, human serum, or enriched plasma; serum-free, serum replacement nonconditioned medium, or ad hoc formula ? All that glitters is not gold! Stem Cells 2007; 25 : 1603–9.
  10. Gripon P, Rumin S, Urban S, et al. Infection of a human hepatoma cell line by hepatitis b virus. Proc Natl Acad Sci USA 2002; 99 : 15655–60.
  11. Cerec V, Glaise D, Garnier D, et al. Transdifferentiation of hepatocyte-like cells from the human hepatoma heparg cell line through bipotent progenitor. Hepatology 2007; 45 : 957–67.
  12. Aninat C, Piton A, Glaise D, et al. Expression of cytochromes p450, conjugating enzymes and nuclear receptors in human hepatoma heparg cells. Drug Metab Dispos 2006; 34 : 75–83.
  13. Josse R, Aninat C, Glaise D, et al. Long-term functional stability of human heparg hepatocytes and use for chronic toxicity and genotoxicity studies. Drug Metab Dispos 2008; 36 : 1111–8.
  14. Suter L, Babiss LE, Wheeldon EB. Toxicogenomics in predictive toxicology in drug development. Chem Biol 2004; 11; 161–71.
  15. Robertson DG. Metabonomics in toxicology: a review. Toxicol Sci 2005; 85 : 809–22.
  16. Nicholson JK, Lindon JC, Holmes E. Metabonomics: understanding the metabolic responses of living systems to pathophysiological stimuli via multovariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 1999; 29 : 1181–9.
  17. McMillian M, Nie A, Parker B, et al. Drug-induced oxidative stress in rat liver from a toxicogenomic perspective. Toxicol Appl Pharmacol 2005; 207 : 171–8.
  18. Wang EJ, Snyder RD, Fielden MR, et al. Validation of putative biomarkers of nephrotoxicity in rats. Toxicology 2008; 246 : 91–100.
  19. Ellinger-Ziegelbauer H, Gmuender H, Badenburg A, Ahr HJ. Prediction of a carcinogenic potential of rat hepatocarcinogens using toxicogenomics analysis of short-term in vivo studies. Mutat Res 2008; 637 : 23–39.
  20. Fella K, Gluckmann M, Hellmann J, et al. Use of two-dimensional gel electrophoresis in predictive toxicology: Identification of potential early protein bimarkers in chemically induced hepatocarcinogenesis. Proteomics 2005; 5 : 1914–27.
  21. Sawada H, Takami K, Asahi S. A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci 2005; 83 : 282–92.
  22. European Medicines Agency (EMEA). Final report on the pilot joint EMEA/FDA VXDS experience on qualification of nephrotoxicity biomarkers. EMEA, 2008 (Ref EMEA/250885/2008).
  23. MAQC Consortium. The microarray quality control (MAQC) project shows inter and intraplatform reproducibility of gene expression measurements. Nat Biotechnol 2006; 24 : 1151–61.

Les statistiques affichées correspondent au cumul d'une part des vues des résumés de l'article et d'autre part des vues et téléchargements de l'article plein-texte (PDF, Full-HTML, ePub... selon les formats disponibles) sur la platefome Vision4Press.

Les statistiques sont disponibles avec un délai de 48 à 96 heures et sont mises à jour quotidiennement en semaine.

Le chargement des statistiques peut être long.