Accès gratuit
Med Sci (Paris)
Volume 21, Numéro 6-7, Juin–Juillet 2005
Page(s) 663 - 668
Section Recherche et partenariat
Publié en ligne 15 juin 2005
  1. Organisation Mondiale de la Santé. Guidelines for preclinical evaluation and clinical trials in osteoporosis. Geneva : WHO, 1998.
  2. Baudoin C, Fardellone P, Bean K, et al. Clinical outcomes and mortality after hip fracture : a 2-year follow-up study. Bone 1996; 18 (suppl 3) : S149–57.
  3. McCreadie BR, Goldstein SA. Biomechanics of fracture : Is bone mineral density sufficient to assess risk ? J Bone Miner Res 2000; 15 : 2305–8.
  4. Nguyen TV, Eisman JA. Genetics of fracture : challenges and opportunities. J Bone Miner Res 2000; 15 : 1253–6.
  5. Ralston SH. The genetics of osteoporosis. Bone 1999; 25 : 85–6.
  6. Harvey N, Cooper C. Determinants of fracture risk in osteoporosis. Curr Rheumatol Rep 2003; 5 : 75–81.
  7. Jordan KM, Cooper C. Epidemiology of osteoporosis. Best Pract Res Clin Rheumatol 2002; 16 : 795–806.
  8. Baron R, Tsouderos Y. In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation. Eur J Pharmacol 2002; 450 : 11–7.
  9. Takahashi N, Sasaki T, Tsouderos Y, Suda T. S12911-2 inhibits osteoclastic bone resorption in vitro. J Bone Miner Res 2003; 18 : 1082–7.
  10. Canalis E, Hott M, Deloffre P, et al. The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro. Bone 1996; 18 : 517–23.
  11. Chattopadhyay N, Yano S, Tfelt-Hansen J, et al. Strontium ranelate promotes chemotaxis, stimulates proliferation and induces genes involved in the differentiation of rat primary osteoblasts. Bone 2005; 36 : S400.
  12. Meunier PJ, Roux C, Seeman E, et al. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med 2004; 350 : 459–68.
  13. Reginster JY, Seeman E, De Vernejoul MC, et al. Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis : treatment of peripheral osteoporosis (TROPOS) study. J Clin Endocrinol Metab 2005; 90 : 2916–822.
  14. Suda T, Takahashi N, Udagawa N, et al. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocrinol Rev 1999; 20 : 345–57.
  15. Teitelbaum SL. Bone resorption by osteoclasts. Science 2000; 289 : 1504–8.
  16. Simonet WS, Lacey DL, Dunstan CR, et al. Osteoprotegerin : a novel secreted protein involved in the regulation of bone density. Cell 1997; 89 : 309–19.
  17. Vaananen HK, Horton M. The osteoclast clear zone is a specialized cell-extracellular matrix adhesion structure. J Cell Sci 1995; 108 : 2729–32.
  18. Manolagas SC. Birth and death of bone cells : basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocrinol Rev 2000; 21 : 115–37.
  19. Silver IA, Murrills RJ, Etherington DJ. Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts. Exp Cell Res 1988; 175 : 266–76.
  20. Lorget F, Kamel S, Mentaverri R, et al. High extracellular calcium concentrations directly stimulate osteoclast apoptosis. Biochem Biophys Res Commun 2000; 268 : 899–903.
  21. Zaïdi M, Blair HC, Moonga BS, et al. Osteoclastogenesis, bone resorption, and osteoclast-based therapeutics. J Bone Miner Res 2003; 18 :599–609.
  22. Murphy MG, Cerchio K, Stoch SA, et al. Effect of L-000845704, an alphaVbeta3 integrin antagonist, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women. J Clin Endocrinol Metab 2005; 90 : 2022–8.
  23. Lorget F, Mentaverri R, Meddah B, et al. Evaluation of in vitro bone resorption : high-performance liquid chromatography measurement of the pyridinolines released in osteoclast cultures. Anal Biochem 2000; 284 : 375–81.
  24. Kameda T, Mano H, Yuasa T, et al. Estrogen inhibits bone resorption by directly inducing apoptosis of the bone-resorbing osteoclasts. J Exp Med 1997; 186 : 489–95.
  25. Wattel A, Kamel S, Mentaverri R, et al. Potent inhibitory effect of naturally occurring flavonoids quercetin and kaempferol on in vitro osteoclastic bone resorption. Biochem Pharmacol 2003; 65 : 35–42.
  26. Mentaverri R, Kamel S, Wattel A, et al. Regulation of bone resorption and osteoclast survival by nitric oxide : possible involvement of NMDA-receptor. J Cell Biochem 2003; 88 : 1145–56.
  27. Wattel A, Kamel S, Prouillet C, et al. Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NFkappa B and AP-1. J Cell Biochem 2004; 92 : 285–95.
  28. Iotsova V, Caamano J, Loy J, et al. Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2. Nat Med 1997; 3 : 1285–9.
  29. Grigoriadis AE, Wang ZQ, Cecchini MG, et al. c-Fos : a key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science 1994; 266 : 443–8.
  30. Malgaroli A, Meldolesi J, Zallone AZ, et al. Control of cytosolic free calcium in rat and chicken osteoclasts. The role of extracellular calcium and calcitonin. J Biol Chem 1989; 264 :14342–7.
  31. Datta HK, MacIntyre I, Zaidi M. The effect of extracellular calcium elevation on morphology and function of isolated rat osteoclasts. Biosci Rep 1989; 9 : 747–51.
  32. Mentaverri R, Kamel S, Brazier M. Involvement of capacitive calcium entry and calcium store refilling in osteoclastic survival and bone resorption process. Cell Calcium 2003; 34 : 169–75.
  33. Mentaverri R, Hurtel AS, Kamel S, et al. Strontium ranelate directly stimulates osteoclast apoptosis. Osteoporos Int 2004; 15 (suppl 1) : P345MO.
  34. Mentaverri R, Hurtel AS, Wattel A, et al. Calcium-sensing receptor mediates strontium ranelate-induced osteoclasts apoptosis. Bone 2005; 36 : S403.

Les statistiques affichées correspondent au cumul d'une part des vues des résumés de l'article et d'autre part des vues et téléchargements de l'article plein-texte (PDF, Full-HTML, ePub... selon les formats disponibles) sur la platefome Vision4Press.

Les statistiques sont disponibles avec un délai de 48 à 96 heures et sont mises à jour quotidiennement en semaine.

Le chargement des statistiques peut être long.