Prédiction de la réponse à l’Iressa® : un mécanisme inattendu

Benjamin Besse; Thierry Le Chevalier; Jean-Charles Soria

doi:10.1051/medsci/2004208-9750

Accès gratuit

Numéro		Med Sci (Paris) Volume 20, Numéro 8-9, Août-Septembre 2004


Page(s)		750 - 751
Section		Nouvelles
DOI		https://doi.org/10.1051/medsci/2004208-9750
Publié en ligne		15 août 2004

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[1] Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and safety of a specific inhibitor of the Bcr-Abl tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001; 344 : 1031–7. [Google Scholar]

[2] Hill C, Doyon F. Frequency of cancer in France : 2004 update. Bull Cancer 2004; 91 : 9–14. [Google Scholar]

[3] IALT. Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer. N Engl J Med 2004; 350 : 351–60. [Google Scholar]

[4] Schiller JH, Harrington D, Belani CP, et al. Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med 2002; 346 : 92–8. [Google Scholar]

[5] Arteaga CL. ErbB-targeted therapeutic approaches in human cancer. Exp Cell Res 2003; 284 : 122–30. [Google Scholar]

[6] Fayette J, Soria JC. Thérapies moléculaires ciblées : l’exemple de l’Iressa® (ZD1839). Med Sci (Paris) 2003; 19 : 1052–4. [Google Scholar]

[7] Kris MG, Natale RB, Herbst RS, et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer : a randomized trial. JAMA 2003; 290 : 2149–58. [Google Scholar]

[8] Fukuoka M, Yano S, Giaccone G, et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. J Clin Oncol 2003; 21 : 2237–46. [Google Scholar]

[9] Herbst RS, Giaccone G, Schiller JH, et al. Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer : a phase III trial-INTACT 2. J Clin Oncol 2004; 22 : 785–94. [Google Scholar]

[10] Giaccone G, Herbst RS, Manegold C, et al. Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer : a phase III trial-INTACT 1. J Clin Oncol 2004; 22 : 777–84. [Google Scholar]

[11] Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004; 350 : 2129–39. [Google Scholar]

[12] Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer : correlation with clinical response to gefitinib therapy. Science 2004; 304 : 1497–500. [Google Scholar]