Accès gratuit
Med Sci (Paris)
Volume 18, Numéro 4, Avril 2002
Page(s) 429 - 437
Section M/S Revues : Articles de Synthèse
Publié en ligne 15 avril 2002
  1. Conney AH. Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G.H.A. Clowes Memorial Lecture. Cancer Res 1982; 42 : 4875–917.
  2. Okey AB. Enzyme induction in the cytochrome P-450 system. Pharmacol Ther 1990; 45 : 241–98.
  3. Waxman DJ, Azaroff L. Phenobarbital induction of cytochrome P-450 gene expression. Biochem J 1992; 281 : 577–92.
  4. Frueh FW, Zanger UM, Meyer UA. Extent and character of phenobarbital-mediated changes in gene expression in the liver. Mol Pharmacol 1997; 51 : 363–9.
  5. Whysner J, Ross PM, Williams GM. Phenobarbital mechanistic data and risk assessment: enzyme induction, enhanced cell proliferation, and tumor promotion. Pharmacol Ther 1996; 71 : 153–91.
  6. Kemper B. Regulation of cytochrome P450 gene transcription by phenobarbital. Prog Nucleic Acids Res Mol Biol 1998; 61 : 23–64.
  7. Gonzalez FJ. The molecular biology of cytochrome P450s. Pharmacol Rev 1988; 40 : 243–88.
  8. Pitot HC, Dragan YP, Teeguarden J, Hsia S, Campbell H.Quantitation of multistage carcinogenesis in rat liver. Toxicol Pathol 1996; 24 : 119–28.
  9. Lee GH. Paradoxical effects of phenobarbital on mouse hepatocarcinogenesis. Toxicol Pathol 2000; 28 : 215–25.
  10. He JS, Fulco AJ. Abarbiturate-regulated protein binding to a common sequence in the cytochrome P450 genes of rodents and bacteria. J Biol Chem 1991; 266 : 7864–9.
  11. Honkakoski P, Negishi M. Regulatory DNA elements of phenobarbitalresponsive cytochrome P450 CYP2B genes. J Biochem Mol Toxicol 1998; 12 : 3–9.
  12. Trottier E, Belzil A, Stoltz C, Anderson A. Localization of a phenobarbital-responsive element (PBRE) in the 5’-flanking region of the rat CYP2B2 gene. Gene 1995; 158 : 263–8.
  13. Honkakoski P, Moore R, Gynther J, Negishi M. Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes. J Biol Chem 1996; 271 : 9746–53.
  14. Moore JT, Kliewer SA. Use of the nuclear receptor PXR to predict drug interactions. Toxicology 2000; 153 : 1–10.
  15. Dogra SC, Whitelaw ML, May BK. Transcriptional activation of cytochrome P450 genes by different classes of chemical inducers. Clin Exp Pharmacol Physiol 1998; 25: 1–9.
  16. Waxman DJ. P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR. Arch Biochem Biophys 1999; 369 : 11–23.
  17. Honkakoski P, Negishi M. Regulation of cytochrome P450 (CYP) genes by nuclear receptors. Biochem J 2000; 347 : 321–37.
  18. Zelko I, Negishi M. Phenobarbital-elicited activation of nuclear receptor CAR in induction of cytochrome P450 genes. Biochem Biophys Res Commun 2000; 277 : 1–6.
  19. Corcos L, Weiss MC. Phenobarbital, dexamethasone and benzanthracene induce several cytochrome P450 mRNAs in rat hepatoma cells. FEBS Lett 1988; 233 : 37–40.
  20. Hansen AJ, May BK, Eferlink LA. Sequence of a chicken phenobarbital-inducible cytochrome P450 cDNA: regulation of two mRNAs transcribed from different genes. DNA 1989; 8 : 179–91.
  21. Shaw PM, Adesnik M, Weiss MC, Corcos L. The phenobarbital-induced transcriptional activation of cytochrome P-450 genes is blocked by the glucocorticoid-progesterone antagonist RU486. Mol Pharmacol 1993; 44 : 775–83.
  22. Hardwick J P, Gonzalez FJ, Kasper CB. Transcriptional regulation of rat liver epoxide hydratase, NADPH-cytochrome P-450 oxidoreductase, and cytochrome P-450b genes by phenobarbital. J Biol Chem 1983; 258 : 8081–5.
  23. Hahn CN, Hansen AJ, May BK. Transcriptional regulation of the chicken CYP2H1 gene. J Biol Chem 1991; 266 : 17031–9.
  24. Ramsden R, Sommer KM, Omiecinski CJ. Phenobarbital induction and tissue-specific expression of the rat CYP2B2 gene in transgenic mice. J Biol Chem 1993; 268 : 21722–6.
  25. Lee SH, Wang X, DeJong J. Functional interactions between an atypical NF-kappaB site from the rat CYP2B1 promoter and the transcriptional repressor RBP-Jkappa/CBF1. Nucleic Acids Res 2000; 15 : 2091–8.
  26. Handschin C, Podvinec M, Meyer UA. CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR). Proc Natl Acad Sci USA 2000; 97 : 10769–74.
  27. Dogra SC, Benjamin P, Davidson P, May BK. Analysis of a phenobarbital-responsive enhancer sequence located in the 5’ flanking region of the chicken CYP2H1 gene: identification and characterization of functional protein-binding sites. Mol Pharmacol 1999; 55 : 14–22.
  28. Park Y, Li H, Kemper B. Phenobarbital induction mediated by a distal CYP2B2 sequence in rat transiently transfected in situ. J Biol Chem 1996; 271 : 23725–8.
  29. Honkakoski P, Moore R, Washburn K, NegishiM. Activation by diverse xenochemicals of the 51- bp phenobarbitalresponsive enhancer module of the Cyp2b10 gene. Mol Pharmacol 1998; 53 : 597–601.
  30. Honkakoski P, Negishi M. Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene. J Biol Chem 1997; 272 : 14943–9.
  31. Paquet Y, Trottier E, Beaudet MJ, Anderson A. Mutational analysis of the CYP2B2 phenobarbital response unit and inhibitory effect of constitutive androstane receptor on phenobarbital responsiveness. J Biol Chem 2000; 275 : 38427–36.
  32. Honkakoski P, Zelko I, Sueoshi T, Negishi M. The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbitalresponsive enhancer module of the CYP2B gene. Mol Cell Biol 1998; 18 : 5652–8.
  33. Quack M, Carlberg C. Ligand-triggered stabilization of vitamin D receptor/retinoid X receptor heterodimer conformations on DR4-type response elements. J Mol Biol 2000; 296 : 743–56.
  34. Kawamoto T, Sueyoshi T, Zelko I, Moore R, Washburn K, Negishi M. Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Mol Cell Biol 1999; 19: 6318–22.
  35. Sueyoshi T, Kawamoto T, ZelkoI I, Honkakoski P, Negishi M. The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B gene. J Biol Chem 1999; 274 : 6043–6.
  36. Kassam A, Winrow CJ, Fernandez-Rachubinski F, Capone JP, Rachubinski RA. The peroxisome proliferator response element of the gene encoding the peroxisomal betaoxidation enzyme enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase is a target for constitutive androstane receptorbeta/9-cisretinoic acid receptormediated transactivation. J Biol Chem 2000; 275 : 4345–50.
  37. Zhang B, Marcus SL, Sajjadi FG, et al. Identification of a peroxisome proliferatorresponsive element upstream of the gene encoding rat peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase. Proc Natl Acad Sci USA 1992 : 7541–7545.
  38. Yamada H, Yamaguchi T, Oguri K. Suppression of the expression of the CYP2B1/2 gene by retinoic acids. Biochem Biophys Res Commun 2000; 277 : 66–71.
  39. Wan YJ, Yu-Jui Y, Dahsing A, et al. Hepatocytespecific mutation establishes retinoid X receptor a as a heterodimeric integrator of multiple physiological processes in the liver. Mol Cell Biol 2000; 20 : 4436–44.
  40. Forman BM, Tzameli I, Choi HS, et al. Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta. Nature 1998; 395 : 612–5.
  41. Wei P, Zhang J, Egan-Hafley M, Liang S, Moore DD. The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature 2000; 407 : 920–3.
  42. Moore LB, Park DJ, Jones SA, et al. Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J Biol Chem 2000; 275 : 15122–7.
  43. Schuetz EG, Schmid W, Schutz G, et al. The glucocorticoid receptor is essential for induction of cytochrome P-4502B by steroids but not for drug or steroid induction of CYP3A or P-450 reductase in mouse liver. Drug Metab Dispos 2000; 28 : 268–78.
  44. Xie W, Barwick JL, Simon CM, et al. Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. Genes Dev 2000; 14 : 3014–23.
  45. Nirodi CS, Sultana S, Ram N, Prabhu L, Padmanaban G. Involvement of synthesis and phosphorylation of nuclear protein factors that bind to the positive cis-acting element in the transcriptional activation of the CYP2B1/B2 gene by phenobarbitone in vivo. Arch Biochem Biophys 1996; 331 : 79–86.
  46. Kawamura A, Yoshida Y, Kimura N, Oda H, Kakinuma A. Phosphorylation/ dephosphorylation steps are crucial for the induction of CYP2B1 and CYP2B2 gene expression by phenobarbital. Biochem Biophys Res Commun 1999; 264 : 530–6.
  47. Dogra SC, May BK. Phenobarbital-induced activation of CYP2H1 and 5-aminolevulinate synthase genes in chick embryo hepatocytes is blocked by an inhibitor of protein phosphorylation. Arch Biochem Biophys 1996; 327 : 271–8.
  48. Sidhu JS, Omiecinski CJ. cAMP-associated inhibition of phenobarbital-inducible cytochrome P450 gene expression in primary rat hepatocyte cultures. J Biol Chem 1995; 270 : 12762–73.
  49. Marc N, Galisteo M, Lagadic-Gossmann D, et al. Regulation of phenobarbital induction of the cytochrome P450 2b9/10 genes in primary mouse hepatocyte culture. Involvement of calciumand cAMP-dependent pathways. Eur J Biochem 2000; 267 : 963–70.
  50. Sidhu JS, Omiecinski CJ. An okadaic acid-sensitive pathway involved in the phenobarbital-mediated induction of CYP2B gene expression in primary rat hepatocyte cultures. J Pharmacol Exp Ther 1997; 282 : 1122–9.
  51. Geng J, Strobel HW. Expression, induction and regulation of the cytochrome P450 monooxygenase system in the rat glioma C6 cell line. Brain Res 1998; 784 : 276–83.
  52. Pascussi JM, Gerbal-Chaloin S, Fabre JM, Maurel P, Vilarem MJ. Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation. Mol Pharmacol 2000; 58 : 1441–1450.
  53. Damon M, Fautrel A, Guillouzo A, Corcos L. Genetic analysis of the phenobarbital regulation of the cytochrome P-450 2b-9 and aldehyde dehydrogenase type 2 mRNAs in mouse liver. Biochem J 1996; 317 : 481–6.
  54. Dunn TJ, Koleske AJ, Lindahl R, Pitot HC. Phenobarbitalinducible aldehyde dehydrogenase in the rat. cDNA sequence and regulation of the mRNA by phenobarbital in responsive rats. J Biol Chem 1989; 264 : 13057–65.
  55. MarcN, Fautrel A, Damon M, Guillouzo A, Corcos L. Phenobarbital induction of aldehyde dehydrogenase type 2 mRNA in mouse liver: a candidate region on chromosome 7 for a putative regulatory gene. Biochem Genet 2000; 38 : 288–98.

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