Accès gratuit
Med Sci (Paris)
Volume 17, Numéro 12, Décembre 2001
Page(s) 1270 - 1275
Section Articles de Synthèse
Publié en ligne 15 décembre 2001
  1. Karsenty G. The genetic transformation of bone biology. Genes Dev 1999; 13 : 3037–51.
  2. Manolagas SC. Birth and death of bone cells : basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocrinol Rev 2000; 2 : 115–37.
  3. Simonet WS, Lacey DL, Dunstan CR, et al. Osteoprotegerin : a novel secreted protein involved in the regulation of bone density. Cell 1997; 89 : 309–19.
  4. Bucay N, Sarosi I, Dunstan CR, et al. Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 1998; 12 : 1260–8.
  5. Lacey DL, Timms E, Tan HL, et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 1998; 93 : 165–76.
  6. Kong YY, Yoshida H, Sarosi I, et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 1999; 397 : 315–23.
  7. Poli V, Balena R, Fattori E, et al. Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J 1994; 5 : 1189–96.
  8. Couse JF, Korach KS. Estrogen receptor null mice : what have we learned and where will they lead us ? Endocrinol Rev 1999; 3 : 358–417.
  9. Potts JT, and Juppner H. Parathyroid hormone and parathyroid hormone-related peptide in calcium homeostasis, bone metabolism and bone development : the proteins, their genes, and receptors In : Avioli LV, Krane SM, eds. Metabolic bone disease and clinically related disorders. San Diego; Academic Press, 1998.
  10. Nicholson GC, Moseley JM, Sexton PM, et al. Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization. J Clin Invest 1986; 2 : 355–60.
  11. Ducy P, Starbuck M, Priemel M, et al. A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development. Genes Dev 1999; 13 : 1025–36.
  12. Corral DA, Amling M, Priemel M, et al. Dissociation between bone resorption and bone formation in osteopenic transgenic mice. Proc Natl Acad Sci USA 1998; 95 : 13835–40.
  13. Felson DT, Zhang Y, Hannan MT, et al. Effects of weight and body mass index on bone mineral density in men and women: The Framingham study. J Bone Miner Res 1993; 8 : 567–73.
  14. Ravn P, Cizza G, Bjarnason NH, et al. Low body mass index is an important risk factor for low bone mass and increased bone loss in early postmenopausal women early postmenopausal intervention cohort (EPIC) study group. J Bone Min Res 999; 14 : 1622–7.
  15. Riggs BL, Melton LJ3d: involutional osteoporosis. N Engl J Med 1986; 314 : 1676–86.
  16. Riggs BL, Khosla S, Melton LJ.3rd. A unitary model for involutional osteoporosis : estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men. J Bone Miner Res 1998; 13 : 763–73.
  17. Tremollieres FA, Pouilles JM, Ribot C. Vertebral post-menopausal bone loss is reduced in overweight women : a longitudinal study in 155 early postmenopausal women. J Clin Endocrinol Metab 1993; 77 : 683–6.
  18. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998; 395 : 763–70.
  19. Spiegelman BM, Flier JS. Adipogenesis and obesity : rounding out the big picture. Cell 1996; 87 : 377–89.
  20. Chen H, Charlat O, Tartaglia LA, et al. Evidence that the diabetes gene encodes the leptin receptor : identification of a mutation in the leptin receptor gene in db/db mice. Cell 1996; 84 : 491–5.
  21. Clement K, Vaisse C, Lahlou N, et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998; 392 : 398–401.
  22. Lee GH, Proenca R, Montez JM, et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996; 379 : 632–5.
  23. Montague CT, Farooqi IS, Whitehead JP, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997; 387 : 903–8.
  24. Strobel A, Issad T, Camoin L, et al. A leptin missense mutation associated with hypogonadism and morbid obesity. Nat Genet 1998; 3 : 213–5.
  25. Tartaglia LA, Dembski M, Weng X, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995; 83 : 1263–71.
  26. Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue Nature 1994; 372 : 425–32 et 1995; 374 : 479 (erratum).
  27. Ducy P, Amling M, Takeda S, et al. Leptin inhibits bone formation through a hypothalamic relay : a central control of bone mass. Cell 2000; 2 : 197–207.
  28. Dinulescu DM, Cone RD. Agouti and agouti-related protein : analogies and contrasts. J Biol Chem 2000; 275 : 6695–8.
  29. Lu D, Willard D, Patel IR, et al. Agouti protein is an antagonist of the melanocyte-stimulating-hromone receptor. Nature 1994; 371 : 799–802.
  30. Parfitt AM, Drezner MK, Glorieux FH, et al. Bone histomorphometry : standardization of nomenclature, symbols, and units. Report of the ASBMR histomorphometry nomenclature committee. J Bone Miner Res 1987; 6 : 595–610.
  31. Ahima RS, Prabakaran D, Mantzoros C, et al. Role of leptin in the neuroendocrine response to fasting. Nature 1996; 382 : 25052.
  32. Reid IR. Preventing glucocorticoid-induced osteoporosis. N Engl J Med 1997; 337 : 420–1.
  33. Thomas T, Gori F, Khosla S, et al. Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes. Endocrinology 1999; 140 : 1630–8.
  34. Baumann H, Morella KK, White DW, et al. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA 1996; 93 : 8374–5.
  35. Elmquist JK, Ahima RS, Maratos-Flier E, et al. Leptin activates neurons in ventrobasal hypothalamus and brainstem. Endocrinology 1997; 138 : 839–42.
  36. Ghilardi N, Ziegler S, Wiestner A, et al. Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci USA 1996; 93 : 6231–5.
  37. Moitra J, Mason MM, Olive M, et al. Life without white fat : a transgenic mouse. Genes Dev 1998; 12 : 3168–81.
  38. Vaisse C, Halaas JL, Horvath CM, et al. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat Genet 1996; 14 : 95–7.
  39. Ahn S, Olive M, Aggarwal S, et al. A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos. Mol Cell Biol 1998; 2 : 967–77.
  40. Levy JB, Schindler C, Raz R, et al. Activation of the JAK-STAT signal transduction pathway by oncostatin-M cultured human and mouse osteoblastic cells. Endocrinology 1996; 137 : 1159–65.
  41. Bellido T, Stahl N, Farruggella TJ, et al. Detection of receptors for interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal/osteoblastic cells. J Clin Invest 1996; 2 : 431–7.
  42. Westvik J. Radiological features in generalized lipodystrophy. Acta Paediatr 1996; 413 (suppl) : 44–51.
  43. Halaas JL, Boozer C, Blair-West J, et al. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci USA 1997; 94 : 8878–83.
  44. Elmquist JK, Elias CF, Saper CB. From lesions to leptin : hypothalamic control of food intake and body weight. Neuron 1999; 2 : 221–32.
  45. Marsh DJ, Hollopeter G, Huszar D, et al. Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat Genet 1999; 1 : 119–22.
  46. Erickson JC, Hollopeter G, Palmiter RD. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 1996; 274 : 1704–7.
  47. Schwartz MW, Erickson JC, Baskin DG, et al. Effect of fasting and leptin deficiency on hypothalamic neuropeptide Y gene transcription in vivo revealed by expression of a lacZ reporter gene. Endocrinology 1998; 5 : 2629–35.
  48. Jochum W, David JP, Elliott C, et al. Increased bone formation and osteosclerosis in mice overexpressing the transcriptin factor fra-1. Nat Med 2000; 6 : 980–4.

Les statistiques affichées correspondent au cumul d'une part des vues des résumés de l'article et d'autre part des vues et téléchargements de l'article plein-texte (PDF, Full-HTML, ePub... selon les formats disponibles) sur la platefome Vision4Press.

Les statistiques sont disponibles avec un délai de 48 à 96 heures et sont mises à jour quotidiennement en semaine.

Le chargement des statistiques peut être long.