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Tableau I.
Classification des inhibiteurs de HDACs dans les essais cliniques.
| Inhibiteurs des HDACs | Cible des HDACs | Essai Clinique |
|---|---|---|
| Vorinostat | Toutes classes | Phase I / II / III |
| Ginivostat | Toutes classes | Phase I / II |
| Ricolinostat (ACY-1215, rocilinostat) | Classe IIb (HDAC6) | Phase I / II |
| Acide Valproïque | Classe I et IIa | Phase I / II |
| Acide butyrique | Classe I et IIa | Phase I / II |
| Nicotinamide | Classe III | Phase I / II |
| Citarinostat (ACY-241) | Classe IIb (HDAC6) | Phase I |
| Romidepsine | Classe I | Phase I |
| Trichostatine A | Toutes classes | Pré-Clinique |
| Tubastatine A | Classe IIb (HDAC6) | Pré-Clinique |
| Tubacine | Classe IIb (HDAC6) | Pré-Clinique |
| Nexturastat A (NextA) | Classe IIb (HDAC6) | Pré-Clinique |
| HPOB | Classe IIb (HDAC6) | Pré-Clinique |
| ACY-1083 | Classe IIb (HDAC6) | Pré-Clinique |
| ACY-775 | Classe IIb (HDAC6) | Pré-Clinique |
| CY-738 | Classe IIb (HDAC6) | Pré-Clinique |
| WT161 | Classe IIb (HDAC6) | Pré-Clinique |
| Sirtinol | Classe III (Sirt1 et Sirt2) | Pré-Clinique |
| Cambinol | Classe III (Sirt1 et Sirt2) | Pré-Clinique |
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