Figure 5.
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A. Formule du sacituzumab govitécan, anticorps anti-Trop-2 conjugué au SN-38 via un espaceur clivable (acidité). B. Formule du DS-8201a, trastuzumab conjugué à l’exatécan DX-8951 via un espaceur sensible à la protéolyse. C. Formule du SYD985, trastuzumab anti-HER2/neu conjugué à la seco-DUBA via un espaceur clivable (cathepsine B).
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