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Tableau II.

Les principales classes de donneurs de NO. *Donneur de NO faisant ou ayant fait l’objet d’un essai clinique.

Les dérivés nitrés
  • Trinitrine ou glycéryl trinitrate (GTN)*

  • Isosorbide dinitrate


Les complexes NO-métaux
  • Nitroprussiate de sodium


Les nitrosothiols
  • S-nitrosoglutathione (GSNO)

  • S-nitroso-N-acétyl-D,L-pénicillamine (SNAP)


Les diazeniumdiolates (NONOates)
  • DETA/NO (diethylenetriamine/NO)

  • DETA/NONOate (diethylenetriamine/diazeniumdiolate)


Les hybrides NO-drogues
  • NO-non steroidal anti-inflammatory drugs (NO-NSAID)

  • NO-naproxen, NO-aspirine : NO-donating acetylsalicylic acid (NO-ASA), NCX-4016*, NCX-4040, NCX-4215, etc.

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