Tableau I.
Principaux sous-types de cellules dendritiques et leurs marqueurs de différenciation. *Une sous-population de mCD1 pulmonaires exprime le CD1a. § On retrouve dans les organes lymphoïdes des CD immatures exprimant soit le CD4, soit le CD8α. BDCA4 : neuropilin-1 ; cCD : cellule dendritique conventionnelle ; CLEC : C-type lectin-like protein ; infCD : cellule dendritique inflammatoire ; mCD : cellule dendritique myéloïde ; MHC : major histocompatibility complex ; moDC : cellule dendritique dérivée du monocyte ; pCD : cellule dendritique plasmacytoïde ; XCR : C-subfamily of chemokine receptor.
| CD murines | CD humaines |
|---|---|
| CD11b+ cDC | mCD 1 |
| CD11c, CD11b, MHCII, CD4§, CD8α§, TLR1, 2, 3, 4, 5, 6, 9 | CD1c/BDCA1, CD1a*, CD4§, CD8α§, CD11b, CD11c, MHCII, FcεRI, TLR1, 2, 3, 4, 5, 6, 9 |
|
|
|
| CD103+ cDC | mCD 2 |
| CD1c, CD11c, CD103, langerine, MHCII, TLR1, 2, 3, 4, 5, 6, 9 | CD141/BDCA3, CD11c, MHCII, CLEC9A, XCR1, TLR3 |
| CD pulmonaires CD1a+ CD1c- | |
| CD1a, langerine, MHCII | |
|
|
|
| pCD | pCD |
| MHCII, BDCA2, BDCA4, CD123 (IL-3Rα), CD4, FcεRI, Ly6C TLR7, 9 | MHCII, CD123 (IL-3Rα), CD4, Ly6C, TLR7, 9 |
|
|
|
| infCD | infCD |
| MHCII, CD11b, CD11c, F4/80, CD64, Ly6C, FcεRI | MHCII, CD1c/BDCA1, CD1a, CD11b, FcεRI, CD206, CD172a, CD14, TLR1, 2, 3, 4, 5, 6, 9 |
| moCD | |
| HLA-DR, CD1a, CD11c, CD83 | |
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