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Tableau III
Composés agonistes en cours de développement ciblant TLR8.
Cible des agonistes | Nom | Compagnie | Indication | Statut de l’essai |
---|---|---|---|---|
TLR8 | VTX-1463 | VantiRX Pharmaceuticals Inc. | Rhinite allergique | Phase I |
TLR8 | VTX-2337 | VantiRX Pharmaceuticals Inc. | Cancer | Phase I |
TLR7, TLR8 et TLR9 | CPG 52364 | Pfizer | Lupus érythémateux disséminé | Phase I |
TLR7 et TLR8 | Resiquimod | 3M Pharmaceuticals | Hépatite C, herpès | Suspendu en phase III |
TLR7 et TLR8 | IMO-4020 | Idera Pharmaceuticals | Lymphome | Préclinique |
TLR7, TLR8 et TLR9 | Adjuvant vaccinal | Idera Pharmaceuticals | Maladies infectieuses, cancer, maladie d’Alzheimer | Préclinique |
TLR7 et TLR8 | VTX-463 | Array BioPharma | Allergie | Préclinique |
TLR8 | VTX-763 | VantiRX Pharmaceuticals Inc. | Inflammation auto-immune | Préclinique |
TLR7 et TLR8 | IPH 3201 | Innate Pharma | Adjuvant vaccinal | Préclinique |
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