Figure 3.
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Fonction inhibitrice de CTLA-4. Dans un contexte de reconnaissance antigénique, les signaux de costimulation via CD28 (ici PI3K-indépendant) peuvent être inhibés par l’intervention de CTLA-4. ZAP-70 : zeta-chain-associated protein kinase of 70 kDa ; LAT : linker of activation in T cell ; SLP-76 : SH2-domain-containing leukocyte protein of 76 kDa ; PKC θ : protein kinase C θ ; CARMA1 : caspase recruitment domain (CARD)-containing membrane-associated guanylate kinase (MAGUK) protein-1 ; cSMAC : central supramolecular activation cluster.
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