| Issue |
Med Sci (Paris)
Volume 35, Number 8-9, Août–Septembre 2019
|
|
|---|---|---|
| Page(s) | 643 - 650 | |
| Section | M/S Revues | |
| DOI | https://doi.org/10.1051/medsci/2019131 | |
| Published online | 18 September 2019 | |
Les fonctions de l’innervation sympathique artérielle
Du développement à la pathologie
The functions of arterial sympathetic innervation: from development to pathology
Centre Interdisciplinaire de Recherche en Biologie (CIRB), Collège de France, Inserm U1050, CNRS UMR 7241, 11, place Marcelin Berthelot, 75005 Paris, France
* isabelle.brunet@college-de-france.fr
L’innervation sympathique artérielle (ISA) est un processus biologique complexe nécessitant un guidage fin des axones des neurones sympathiques par les artères. L’ISA est un élément clé de l’adaptation du système cardiovasculaire aux différentes contraintes (exposition au froid, exercice, etc.) : elle contrôle le diamètre des artères de résistance, donc le flux sanguin parvenant aux organes et la pression artérielle systémique via la modulation du tonus artériel. Son importance lors du vieillissement et dans de nombreux contextes pathologiques est de mieux en mieux reconnue et comprise. Son intégration à la prise en charge de nombreuses maladies (hypertension, cancer, etc.) permettrait d’en améliorer traitements et pronostic.
Abstract
Arterial sympathetic innervation (ASI) is a complex biological process requiring a fine axonal guidance by arteries. Its physiological impact has remained unknown for decades but recently started to be better understood and recognized. ASI is a key element of the adaptive response of the cardiovascular system to challenging situations (exposure to cold, exercise…) as ASI controls the diameter of resistance arteries, thus blood supply to organs and systemic arterial blood pressure via arterial tone modulation. Defaults in ASI can lead to diseases, acting as a main cause or as an aggravating factor. Its impact is actively studied in cardiovascular diseases representing major public health issues, like hypertension, but ASI could also play a role in aging and many more pathological processes including cancer.
© 2019 médecine/sciences – Inserm
Article publié sous les conditions définies par la licence Creative Commons Attribution License CC-BY (http://creativecommons.org/licenses/by/4.0), qui autorise sans restrictions l'utilisation, la diffusion, et la reproduction sur quelque support que ce soit, sous réserve de citation correcte de la publication originale.
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