Open Access
Issue
Med Sci (Paris)
Volume 42, Number 2, Février 2026
Page(s) 153 - 163
Section M/S Revues
DOI https://doi.org/10.1051/medsci/2026014
Published online 24 February 2026
  1. Phelps NH, Singleton RK, Zhou B, et al. Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults. Lancet 2024 ; 403 : 1027–50. [Google Scholar]
  2. Chatterjee S, Khunti K, Davies MJ. Type 2 diabetes. Lancet 2017 ; 389 : 2239–51. [CrossRef] [PubMed] [Google Scholar]
  3. Chen W, Kullmann S, Rhea EM. Expanding the understanding of insulin resistance in brain and periphery. Trends Endocrinol Metab 2025 ; 37 : 17–30. [Google Scholar]
  4. Berthoud H-R. Mind versus metabolism in the control of food intake and energy balance. Physiol Behav 2004 ; 81 : 781–93. [Google Scholar]
  5. Mattson MP. An Evolutionary perspective on why food overconsumption impairs cognition. Trends Cogn Sci 2019 ; 23 : 200–12. [Google Scholar]
  6. Herbert BM, Pollatos O. Attenuated interoceptive sensitivity in overweight and obese individuals. Eat Behav 2014 ; 15 : 445–8. [Google Scholar]
  7. Saper CB, Chou TC, Elmquist JK. The need to feed: homeostatic and hedonic control of eating. Neuron 2002 ; 36 : 199–211. [Google Scholar]
  8. Boesveldt S, Graaf K de. The differential role of smell and taste for eating behavior. Perception 2017 ; 46 : 307–19. [Google Scholar]
  9. Le Magnen J. My scientific life: 40 years at the College de France. Neurosci Biobehav Rev 2001 ; 25 : 375–94. [Google Scholar]
  10. Yeomans MR. Olfactory influences on appetite and satiety in humans. Physiol Behav 2006 ; 89 : 10–4. [Google Scholar]
  11. Firestein S. How the olfactory system makes sense of scents. Nature 2001 ; 413 : 211–8. [Google Scholar]
  12. Price JL. Beyond the primary olfactory cortex: Olfactory-related areas in the neocortex, thalamus and hypothalamus. Chemical Senses 1985 ; 10 : 239–58. [Google Scholar]
  13. Lepousez G, Gheusi G. Olfaction : quand le cortex redistribue les cartes. Med Sci (Paris) 2011 ; 27 : 687–9. [Google Scholar]
  14. Gottfried JA. Smell: central nervous processing. Adv Otorhinolaryngol 2006 ; 63 : 44–69. [Google Scholar]
  15. Manesse C, Ferdenzi C, Mantel M, et al. The prevalence of olfactory deficits and their effects on eating behavior from childhood to old age: A large-scale study in the French population. Food Quality and Preference 2021 ; 93 : 104273. [Google Scholar]
  16. Landis BN, Konnerth CG, Hummel T. A study on the frequency of olfactory dysfunction. Laryngoscope 2004 ; 114 : 1764–9. [Google Scholar]
  17. Sabiniewicz A, Hoffmann L, Haehner A, et al. Symptoms of depression change with olfactory function. Sci Rep 2022 ; 12 : 5656. [Google Scholar]
  18. Albrecht J, Schreder T, Kleemann AM, et al. Olfactory detection thresholds and pleasantness of a food-related and a non-food odour in hunger and satiety. Rhinology 2009 ; 47 : 160–5. [Google Scholar]
  19. Stark R, Dempsey H, Kleeman E, et al. Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism. Mol Metab 2024 ; 89 : 102025. [Google Scholar]
  20. Julliard AK, Chaput MA, Apelbaum A, et al. Changes in rat olfactory detection performance induced by orexin and leptin mimicking fasting and satiation. Behav Brain Res 2007 ; 183 : 123–9. [Google Scholar]
  21. Palouzier-Paulignan B, Lacroix M-C, Aimé P, et al. Olfaction under metabolic influences. Chem Senses 2012 ; 37 : 769–97. [Google Scholar]
  22. Sorokowska A, Schoen K, Hummel C, et al. Food-related odors activate dopaminergic brain areas. Front Hum Neurosci 2017 ; 11 : 625. [Google Scholar]
  23. Soria-Gómez E, Bellocchio L, Reguero L, et al. The endocannabinoid system controls food intake via olfactory processes. Nat Neurosci 2014 ; 17 : 407–15. [Google Scholar]
  24. Montaner M, Denom J, Jiang W, et al. The local GLP-1 system in the olfactory bulb is required for odor-evoked cephalic phase of insulin release in mice. Mol Metab 2023 ; 73 : 101738. [Google Scholar]
  25. Fernandez-Garcia JC, Alcaide J, Santiago-Fernandez C, et al. An increase in visceral fat is associated with a decrease in the taste and olfactory capacity. PLOS ONE 2017 ; 12 : e0171204. [Google Scholar]
  26. Zhang Z, Liu Q, Wen P, et al. Activation of the dopaminergic pathway from VTA to the medial olfactory tubercle generates odor-preference and reward. Elife 2017 ; 6 : e25423. [Google Scholar]
  27. Martin LE, Holsen LM, Chambers RJ, et al. Neural mechanisms associated with food motivation in obese and healthy weight adults. Obesity (Silver Spring) 2010 ; 18 : 254–60. [Google Scholar]
  28. Peng M, Coutts D, Wang T, et al. Systematic review of olfactory shifts related to obesity. Obes Rev 2019 ; 20 : 325–338. [Google Scholar]
  29. Melis M, Pintus S, Mastinu M, et al. Changes of taste, smell and eating behavior in patients undergoing bariatric surgery: associations with prop phenotypes and polymorphisms in the odorant-binding protein OBPIIa and CD36 receptor genes. Nutrients 2021 ; 13 : 250. [Google Scholar]
  30. Jorgensen MB, Buch NH. Studies on the sense of smell and taste in diabetics. Acta Otolaryngol 1961 ; 53 : 539–45. [Google Scholar]
  31. Naka A, Riedl M, Luger A, et al. Clinical significance of smell and taste disorders in patients with diabetes mellitus. Eur Arch Otorhinolaryngol 2010 ; 267 : 547–50. [Google Scholar]
  32. Yazla S, Özmen S, Kıyıcı S, et al. Evaluation of olfaction and taste function in type 2 diabetic patients with and without peripheral neuropathy. Diabetes Metab Res Rev 2018 ; 34. [Google Scholar]
  33. Biessels GJ, Despa F. Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications. Nat Rev Endocrinol 2018 ; 14 : 591–604. [Google Scholar]
  34. Sadanand S, Balachandar R, Bharath S. Memory and executive functions in persons with type 2 diabetes: a meta-analysis. Diabetes Metab Res Rev 2016 ; 32 : 132–42. [Google Scholar]
  35. Sanke H, Mita T, Yoshii H, et al. Olfactory dysfunction predicts the development of dementia in older patients with type 2 diabetes. Diabetes Res Clin Pract 2021 ; 174 : 108740. [Google Scholar]
  36. Zhang Z, Zhang B, Wang X, et al. Altered odor-induced brain activity as an early manifestation of cognitive decline in patients with type 2 diabetes. Diabetes 2018 ; 67 : 994–1006. [Google Scholar]
  37. Chen M, Wang J, Zhou S, et al. Brain structure as a correlate of odor identification and cognition in type 2 diabetes. Front Hum Neurosci 2022 ; 16 : 773309. [Google Scholar]
  38. Stafford LD, Welbeck K. High hunger state increases olfactory sensitivity to neutral but not food odors. Chem Senses 2011 ; 36 : 189–98. [Google Scholar]
  39. Stafford LD, Whittle A. Obese individuals have higher preference and sensitivity to odor of chocolate. Chem Senses 2015 ; 40 : 279–84. [Google Scholar]
  40. Trellakis S, Tagay S, Fischer C, et al. Ghrelin, leptin and adiponectin as possible predictors of the hedonic value of odors. Regul Pept 2011 ; 167 : 112–7. [Google Scholar]
  41. Mas M, Brindisi M-C, Chabanet C, et al. Implicit food odour priming effects on reactivity and inhibitory control towards foods. PLoS One 2020 ; 15 : e0228830. [Google Scholar]
  42. Lietzau G, Nyström T, Wang Z, et al. Western diet accelerates the impairment of odor-related learning and olfactory memory in the mouse. ACS Chem Neurosci 2020 ; 11 : 3590–602. [Google Scholar]
  43. Takase K, Tsuneoka Y, Oda S, et al. High-fat diet feeding alters olfactory-, social-, and reward-related behaviors of mice independent of obesity. Obesity (Silver Spring) 2016 ; 24 : 886–94. [Google Scholar]
  44. Lacroix M-C, Caillol M, Durieux D, et al. Long-lasting metabolic imbalance related to obesity alters olfactory tissue homeostasis and impairs olfactory-driven behaviors. Chem Senses 2015 ; 40 : 537–56. [Google Scholar]
  45. Al Koborssy D, Palouzier-Paulignan B, Canova V, et al. Modulation of olfactory-driven behavior by metabolic signals: role of the piriform cortex. Brain Struct Funct 2019 ; 224 : 315–36. [Google Scholar]
  46. Julliard A-K, Al Koborssy D, Fadool DA, et al. Nutrient sensing: another chemosensitivity of the olfactory system. Front Physiol 2017 ; 8 : 468. [Google Scholar]
  47. Faour M, Magnan C, Gurden H, et al. Olfaction in the context of obesity and diabetes: Insights from animal models to humans. Neuropharmacology 2022 ; 206 : 108923. [Google Scholar]
  48. Aimé P, Palouzier-Paulignan B, Salem R, et al. Modulation of olfactory sensitivity and glucose-sensing by the feeding state in obese Zucker rats. Front Behav Neurosci 2014 ; 8 : 326. [Google Scholar]
  49. Al Koborssy D, Palouzier-Paulignan B, Salem R, et al. Cellular and molecular cues of glucose sensing in the rat olfactory bulb. Front Neurosci 2014 ; 8 : 333. [Google Scholar]
  50. Fadool DA, Tucker K, Pedarzani P. Mitral cells of the olfactory bulb perform metabolic sensing and are disrupted by obesity at the level of the Kv1.3 ion channel. PLoS One 2011 ; 6 : e24921. [Google Scholar]
  51. Poessel M, Freiherr J, Wiencke K, et al. Insulin resistance is associated with reduced food odor sensitivity across a wide range of body weights. Nutrients 2020 ; 12 : 2201. [Google Scholar]
  52. Min J-Y, Min K-B. Insulin resistance and the increased risk for smell dysfunction in US adults. Laryngoscope 2018 ; 128 : 1992–6. [Google Scholar]
  53. Bell GA, Fadool DA. Awake, long-term intranasal insulin treatment does not affect object memory, odor discrimination, or reversal learning in mice. Physiol Behav 2017 ; 174 : 104–13. [Google Scholar]
  54. Edwin Thanarajah S, Hoffstall V, Rigoux L, et al. The role of insulin sensitivity and intranasally applied insulin on olfactory perception. Sci Rep 2019 ; 9 : 7222. [Google Scholar]
  55. Campolo J, Corradi E, Rizzardi A, et al. Correlates of olfactory impairment in middle-aged non-diabetic Caucasian subjects with stage I-II obesity. Eur Arch Otorhinolaryngol 2021 ; 278 : 2047–54. [Google Scholar]
  56. Zhang Z, Zhang B, Wang X, et al. Olfactory dysfunction mediates adiposity in cognitive impairment of type 2 diabetes: insights from clinical and functional neuroimaging studies. Diabetes Care 2019 ; 42 : 1274–83. [Google Scholar]
  57. Cruciani-Guglielmacci C, Vincent-Lamon M, Rouch C, et al. Early changes in insulin secretion and action induced by high-fat diet are related to a decreased sympathetic tone. Am J Physiol Endocrinol Metab 2005 ; 288 : E148–54. [Google Scholar]
  58. Coucha M, Abdelsaid M, Ward R, et al. Impact of metabolic diseases on cerebral circulation: structural and functional consequences. Compr Physiol 2018 ; 8 : 773–99. [Google Scholar]
  59. Soleimanzad H, Montaner M, Ternier G, et al. Obesity in midlife hampers resting and sensory-evoked cerebral blood flow in mice. Obesity (Silver Spring) 2021 ; 29 : 150–8. [Google Scholar]
  60. Soleimanzad H, Morisset C, Montaner M, et al. Western diet since adolescence impairs brain functional hyperemia at adulthood in mice: rescue by a balanced ω-3:ω-6 polyunsaturated fatty acids ratio. Int J Obes (Lond) 2025 ; 49 : 844–54. [Google Scholar]
  61. Negoias S, Croy I, Gerber J, et al. Reduced olfactory bulb volume and olfactory sensitivity in patients with acute major depression. Neuroscience 2010 ; 169 : 415–21. [Google Scholar]
  62. Gudziol V, Buschhüter D, Abolmaali N, et al. Increasing olfactory bulb volume due to treatment of chronic rhinosinusitis--a longitudinal study. Brain 2009 ; 132 : 3096–101. [Google Scholar]
  63. Mazal PP, Haehner A, Hummel T. Relation of the volume of the olfactory bulb to psychophysical measures of olfactory function. Eur Arch Otorhinolaryngol 2016 ; 273 : 1–7. [Google Scholar]
  64. Poessel M, Breuer N, Joshi A, et al. Reduced olfactory bulb volume in obesity and its relation to metabolic health status. Front Hum Neurosci 2020 ; 14 : 586998. [Google Scholar]
  65. Thiebaud N, Llewellyn-Smith IJ, Gribble F, et al. The incretin hormone glucagon-like peptide 1 increases mitral cell excitability by decreasing conductance of a voltage-dependent potassium channel. J Physiol 2016 ; 594 : 2607–28. [Google Scholar]
  66. Ahrén B, Holst JJ. The cephalic insulin response to meal ingestion in humans is dependent on both cholinergic and noncholinergic mechanisms and is important for postprandial glycemia. Diabetes 2001 ; 50 : 1030–8. [Google Scholar]
  67. Montaner M, Denom J, Simon V, et al. A neuronal circuit driven by GLP-1 in the olfactory bulb regulates insulin secretion. Nat Commun 2024 ; 15 : 6941. [Google Scholar]
  68. Fontbonne A, Currie A, Tounian P, et al. Prevalence of overweight and obesity in France: the 2020 obepi-roche study by the “Ligue contre l’obésité.” J Clin Med 2023 ; 12 : 925. [Google Scholar]
  69. Niechciał E, Wais P, Bajtek J, et al. Current perspectives for treating adolescents with obesity and type 2 diabetes: a review. Nutrients 2024 ; 16 : 4084. [Google Scholar]
  70. Holst JJ. GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management. Nat Metab 2024 ; 6 : 1866–85. [Google Scholar]
  71. Rodriguez PJ, Zhang V, Gratzl S, et al. Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists among US adults with overweight or obesity. JAMA Netw Open 2025 ; 8 : e2457349. [Google Scholar]
  72. Lah S, Hocking SL. Treatment of obesity: will incretin agonists make bariatric surgery a thing of the past? Intern Med J 2025 ; 55 : 369–75. [Google Scholar]
  73. Phan F, Bertrand R, Amouyal C, et al. De la découverte des hormones incrétines aux doubles et triples agonistes GIP / GLP-1 / glucagon. Med Sci (Paris) 2024 ; 40 : 837–47. [Google Scholar]
  74. Glotfelty EJ, Olson L, Karlsson TE, et al. Glucagon-like peptide-1 (GLP-1)-based receptor agonists as a treatment for Parkinson’s disease. Expert Opin Investig Drugs 2020 ; 29 : 595–602. [Google Scholar]
  75. Nyström T, Gutniak MK, Zhang Q, et al. Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease. Am J Physiol Endocrinol Metab 2004 ; 287 : E1209–15. [Google Scholar]
  76. Alvarez E, Martínez MD, Roncero I, et al. The expression of GLP-1 receptor mRNA and protein allows the effect of GLP-1 on glucose metabolism in the human hypothalamus and brainstem. J Neurochem 2005 ; 92 : 798–806. [Google Scholar]

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