EDP Sciences logo
Subscriber Authentication Point
Search
Menu
Home All issues Volume 42 / No 1 (Janvier 2026) Med Sci (Paris), 42 1 (2026) 48-56 References
Open Access
Issue
Med Sci (Paris)
Volume 42, Number 1, Janvier 2026
Page(s) 48 - 56
Section M/S Revues
DOI https://doi.org/10.1051/medsci/2025251
Published online 23 January 2026
  1. Wei X, Zhang F, Cheng D, et al. Free heme induces neuroinflammation and cognitive impairment by microglial activation via the TLR4/MyD88/NF-κB signaling pathway. Cell Comm Signal 2024 ; 22 : 16. [Google Scholar]
  2. Petersen MA, Ryu JK, Chang K-J, et al. Fibrinogen Activates BMP signaling in oligodendrocyte progenitor cells and inhibits remyelination after vascular damage. Neuron 2017 ; 96 : 1003–12.e7. [Google Scholar]
  3. Richards CM, McRae SA, Ranger AL, et al. Extracellular histones as damage-associated molecular patterns in neuroinflammatory responses. Rev Neurosci 2023 ; 34 : 533–58. [Google Scholar]
  4. Cordonnier C, Demchuk A, Ziai W, et al. Intracerebral haemorrhage: current approaches to acute management. Lancet 2018 ; 392 : 1257–68. [Google Scholar]
  5. Li K, Jiang H, Yu J, et al. Determinants of Leptomeningeal Collateral Status in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis of Observational Studies. J Am Heart Assoc 2024 ; 3 : e034170. [Google Scholar]
  6. Seeters T van, Biessels GJ, Kappelle LJ, et al. Determinants of leptomeningeal collateral flow in stroke patients with a middle cerebral artery occlusion. Neuroradiology 2016 ; 58 : 969–77. [Google Scholar]
  7. Mazighi M, Chaudhry SA, Ribo M, et al. Impact of onset-to-reperfusion time on stroke mortality: a collaborative pooled analysis. Circulation 2013 ; 127 : 1980–5. [Google Scholar]
  8. Ho-Tin-Noé B, Desilles JP, Mazighi M. Thrombus composition and thrombolysis resistance in stroke. Res Pract Thromb Haemost 2023 ; 7 : 100178. [Google Scholar]
  9. Pauillac N, Faille D, Solo Nomenjanahary M, et al. fibrinogen depletion coagulopathy and hemorrhagic transformation in acute ischemic stroke treated with bridging therapy. Stroke 2025 ; 56 : 2009–20. [Google Scholar]
  10. Christou I, Burgin WS, Alexandrov AV, et al. Arterial status after intravenous TPA therapy for ischaemic stroke. A need for further interventions. Int Angiol 2001 ; 20 : 208–13. [Google Scholar]
  11. Seners P, Turc G, Maïer B, et al. incidence and predictors of early recanalization after intravenous thrombolysis: a systematic review and meta-analysis. Stroke 2016 ; 47 : 2409–12. [Google Scholar]
  12. Saqqur M, Uchino K, Demchuk AM, et al. site of arterial occlusion identified by transcranial doppler predicts the response to intravenous thrombolysis for stroke. Stroke 2007 ; 38 : 948–54. [Google Scholar]
  13. Kleindorfer D, Kissela B, Schneider A, et al. eligibility for recombinant tissue plasminogen activator in acute ischemic stroke. Stroke 2004 ; 35 : e27–9. [Google Scholar]
  14. Forestier G, Kerleroux B, Janot K, et al. Mechanical thrombectomy practices in France: Exhaustive survey of centers and individual operators. J Neuroradiol 2020 ; 47 : 410–5. [Google Scholar]
  15. Zhu F, Kerleroux B, Pruvo JP, et al. Breaking the glass ceiling for mechanical thrombectomy access in france. J Neuroradiol 2024 ; 51 : 43–6. [Google Scholar]
  16. Singer OC, Berkefeld J, Nolte CH, et al. Mechanical recanalization in basilar artery occlusion: The ENDOSTROKE study. Ann Neurol 2015 ; 77 : 415–24. [Google Scholar]
  17. Elijovich L, Goyal N, Mainali S, et al. CTA collateral score predicts infarct volume and clinical outcome after endovascular therapy for acute ischemic stroke: a retrospective chart review. J Neurointerv Surg 2016 ; 8 : 559–62. [Google Scholar]
  18. Belge Bilgin G, Bilgin C, Jabal MS, et al. The effects of admission hyperglycemia and diabetes mellitus on mechanical thrombectomy outcomes: A systematic review and meta-analysis. Interv Neuroradiol 2025. [Google Scholar]
  19. Tanguay JF, Geoffroy P, Dorval JF, et al. Percutaneous endoluminal arterial cryoenergy improves vascular remodelling after angioplasty. Thromb Haemost 2004 ; 92 : 1114–21. [Google Scholar]
  20. Engelmann B, Massberg S. Thrombosis as an intravascular effector of innate immunity. Nat Rev Immunol 2013 ; 13 : 34–45. [CrossRef] [PubMed] [Google Scholar]
  21. Marder VJ, Chute DJ, Starkman S, et al. Analysis of thrombi retrieved from cerebral arteries of patients with acute ischemic stroke. Stroke 2006 ; 37 : 2086–93. [Google Scholar]
  22. Ducroux C, Meglio L Di, Loyau S, et al. Thrombus neutrophil extracellular traps content impair tPA-induced thrombolysis in acute ischemic stroke. Stroke 2018 ; 49 : 754–7. [Google Scholar]
  23. Denorme F, Langhauser F, Desender L, et al. ADAMTS13-mediated thrombolysis of t-PA-resistant occlusions in ischemic stroke in mice. Blood 2016 ; 127 : 2337–45. [Google Scholar]
  24. Laridan E, Denorme F, Desender L, et al. Neutrophil extracellular traps in ischemic stroke thrombi. Ann Neurol 2017 ; 82 : 223–32. [Google Scholar]
  25. Staessens S, Denorme F, François O, et al. Structural analysis of ischemic stroke thrombi: Histological indications for therapy resistance. Haematologica 2020 ; 105 : 498–507. [Google Scholar]
  26. Meglio L Di, Desilles JP, Ollivier V, et al. Acute ischemic stroke thrombi have an outer shell that impairs fibrinolysis. Neurology 2019 ; 93 : E1686–98. [Google Scholar]
  27. Meglio L Di, Desilles JP, Mazighi M, et al. Thrombolysis-resistant intracranial clot. Neurology 2018 ; 90 : 1075. [Google Scholar]
  28. Grixti JM, Chandran A, Pretorius J-H, et al. amyloid presence in acute ischemic stroke thrombi: observational evidence for fibrinolytic resistance. Stroke 2025 ; 56 : e165–7. [Google Scholar]
  29. Ahn SH, Hong R, Choo IS, et al. Histologic features of acute thrombi retrieved from stroke patients during mechanical reperfusion therapy. Int J Stroke 2016 ; 11 : 1036–44. [Google Scholar]
  30. Drabik L, Wołkow P, Undas A. Fibrin clot permeability as a predictor of stroke and bleeding in anticoagulated patients with atrial fibrillation. Stroke 2017 ; 48 : 2716–22. [Google Scholar]
  31. Carr ME, Alving BM. Effect of fibrin structure on plasmin-mediated dissolution of plasma clots. Blood Coagul Fibrinolysis 1995 ; 6 : 567–73. [Google Scholar]
  32. Desilles JP, Meglio L Di, Delvoye F, et al. composition and organization of acute ischemic stroke thrombus: a wealth of information for future thrombolytic strategies. Front Neurol 2022 ; 13 : 870331. [Google Scholar]
  33. Veyradier A, Coppo P. ADAMTS13, la protéase spécifique du clivage du facteur von Willebrand. Med Sci (Paris) 2011 ; 27 : 1097–105. [Google Scholar]
  34. Kim D, Shea SM, Ku DN. Lysis of arterial thrombi by perfusion of N,N’-Diacetyl-L-cystine (DiNAC). PLoS One 2021 ; 16 : e0247496. [Google Scholar]
  35. Lizarrondo SM De, Gakuba C, Herbig BA, et al. Potent thrombolytic effect of N-acetylcysteine on arterial thrombi. Circulation 2017 ; 136 : 646–60. [Google Scholar]
  36. Vandelanotte S, François O, Desender L, et al. R-tPA resistance is specific for platelet-rich stroke thrombi and can be overcome by targeting nonfibrin components. Stroke 2024 ; 55 : 1181–90. [Google Scholar]
  37. Komakula S, Bhatia R, Sahib A, et al. Safety and efficacy of N-acetylcysteine (NAC) as an adjunct to standard treatment in patients with acute ischemic stroke: a randomized controlled pilot trial (NACTLYS). Sci Rep 2024 ; 14 : 1103. [Google Scholar]
  38. Vivien D, Lebatard S, Mazighi M, et al. N-acetylcysteine (NAC) as an adjunct to intravenous fibrinolysis in patients with acute ischemic stroke: a single group study (NAC-Safety). Neuroscience 2025 ; 584 : 107–12. [Google Scholar]
  39. Peña-Martínez C, Durán-Laforet V, García-Culebras A, et al. Pharmacological modulation of neutrophil extracellular traps reverses thrombotic stroke tpa (tissue-type plasminogen activator) resistance. Stroke 2019 ; 50 : 3228–37. [Google Scholar]
  40. Zhang S, Cao Y, Du J, et al. Neutrophil extracellular traps contribute to tissue plasminogen activator resistance in acute ischemic stroke. FASEB Journal 2021 ; 35 : e21835. [Google Scholar]
  41. Desilles JP, Solo Nomenjanahary M, Consoli A, et al. Impact of COVID-19 on thrombus composition and response to thrombolysis: Insights from a monocentric cohort population of COVID-19 patients with acute ischemic stroke. J Thromb Haemost 2022 ; 20 : 919–28. [Google Scholar]
  42. Akkipeddi SMK, Rahmani R, Ellens NR, et al. Histone content, and thus DNA content, is associated with differential in vitro lysis of acute ischemic stroke clots. J Thromb Haemost 2024 ; 22 : 1410–20. [Google Scholar]
  43. Cruz DB da, Helms J, Aquino LR, et al. DNA-bound elastase of neutrophil extracellular traps degrades plasminogen, reduces plasmin formation, and decreases fibrinolysis: proof of concept in septic shock plasma. FASEB Journal 2019 ; 33 : 14270–80. [Google Scholar]
  44. Nieswandt B, Kleinschnitz C, Stoll G. Ischaemic stroke: a thrombo-inflammatory disease? J Physiol 2011 ; 589 : 4115–23. [Google Scholar]
  45. Stoll G, Nieswandt B, Schuhmann MK. Ischemia/reperfusion injury in acute human and experimental stroke: focus on thrombo-inflammatory mechanisms and treatments. Neurol Res Pract 2024 ; 6 : 57. [Google Scholar]
  46. Meyer SF De, Denorme F, Langhauser F, et al. Thromboinflammation in stroke brain damage. Stroke 2016 ; 47 : 1165–72. [Google Scholar]
  47. Zoppo GJ del. Microvascular changes during cerebral ischemia and reperfusion. Cerebrovasc Brain Metab Rev 1994 ; 6 : 47–96. [Google Scholar]
  48. Zoppo GJ del. Acute anti-inflammatory approaches to ischemic stroke. Ann NY Acad Sci 2010 ; 1207 : 143–8. [Google Scholar]
  49. Desilles JP, Loyau S, Syvannarath V, et al. Alteplase reduces downstream microvascular thrombosis and improves the benefit of large artery recanalization in stroke. Stroke 2015 ; 46 : 3241–8. [Google Scholar]
  50. Desilles JP, Syvannarath V, Meglio L Di, et al. Downstream microvascular thrombosis in cortical venules is an early response to Proximal Cerebral Arterial occlusion. J Am Heart Assoc 2018 ; 7 : e007804. [Google Scholar]
  51. Kollikowski AM, Schuhmann MK, Nieswandt B, et al. Local leukocyte invasion during hyperacute human ischemic stroke. Ann Neurol 2020 ; 87 : 466–79. [Google Scholar]
  52. Maïer B, Meglio L Di, Desilles P, et al. Neutrophil activation in patients treated with endovascular therapy is associated with unfavorable outcomes and mitigated by intravenous thrombolysis. J Neurointerv Surg 2024 ; 16 : 131–7. [Google Scholar]
  53. Stoll G, Nieswandt B. Thrombo-inflammation in acute ischaemic stroke — implications for treatment. Nat Rev Neurol 2019 ; 15 : 473–81. [Google Scholar]
  54. Desilles JP, Syvannarath V, Ollivier V, et al. Exacerbation of thromboinflammation by hyperglycemia precipitates cerebral infarct growth and hemorrhagic transformation. Stroke 2017 ; 48 : 1932–40. [Google Scholar]
  55. Dupont S, Lebas H, Mavouna S, et al. Comparative effects of glenzocimab and eptifibatide on bleeding severity in 2 mouse models of intracranial hemorrhage. J Am Heart Assoc 2025 ; 14 : e034207. [Google Scholar]
  56. Mazighi M, Köhrmann M, Lemmens R, et al. Safety and efficacy of platelet glycoprotein VI inhibition in acute ischaemic stroke (ACTIMIS): a randomised, double-blind, placebo-controlled, phase 1b/2a trial. Lancet Neurol 2024 ; 23 : 157–67. [Google Scholar]
  57. Meyer SF De, Suidan GL, Fuchs TA, et al. Extracellular chromatin is an important mediator of ischemic stroke in mice. Arterioscler Thromb Vasc Biol 2012 ; 32 : 1884–91. [Google Scholar]
  58. Denorme F, Portier I, Rustad JL, et al. Neutrophil extracellular traps regulate ischemic stroke brain injury. J Clin Invest 2022 ; 132 : e154225. [Google Scholar]
  59. Tuz AA, Ghosh S, Karsch L, et al. Stroke and myocardial infarction induce neutrophil extracellular trap release disrupting lymphoid organ structure and immunoglobulin secretion. Nat Cardiovasc Res 2024 ; 3 : 525–40. [Google Scholar]
  60. Cao J, Roth S, Zhang S, et al. DNA-sensing inflammasomes cause recurrent atherosclerotic stroke. Nature 2024 ; 633 : 433–41. [Google Scholar]
  61. Gauberti M, Fournier AP, Docagne F, et al. Molecular magnetic resonance imaging of endothelial activation in the central nervous system. Theranostics 2018 ; 8 : 1195–212. [Google Scholar]
  62. Jacqmarcq C, Picot A, Flon J, et al. MRI-based microthrombi detection in stroke with polydopamine iron oxide. Nat Commun 2024 ; 15 : 5070. [Google Scholar]

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.