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Home All issues Volume 42 / No 1 (Janvier 2026) Med Sci (Paris), 42 1 (2026) 78-84 References
Open Access
Issue
Med Sci (Paris)
Volume 42, Number 1, Janvier 2026
Page(s) 78 - 84
Section Repères
DOI https://doi.org/10.1051/medsci/2025254
Published online 23 January 2026
  1. Warmflash A, Sorre B, Etoc F, et al. A method to recapitulate early embryonic spatial patterning in human embryonic stem cells. Nat Methods 2014 ; 11 : 847–54. [Google Scholar]
  2. Savatier P, David L, Vos JD, et al. Des embryons chimères et des pseudo-embryons comme alternatives pour la recherche sur l’embryon humain. Med Sci (Paris) 2021 ; 37 : 799–801. [Google Scholar]
  3. Burgaud M, Bretin B, Reignier A, et al. Du nouveau dans les modèles d’étude de l’embryon humain. Med Sci (Paris) 2023 ; 39 : 129–36. [Google Scholar]
  4. Chneiweiss H. Organoïdes : nouvelles perspectives et nouvelles questions éthiques. Med Sci (Paris) 2020 ; 36 : 99–100. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
  5. Baertschi B, Brodin M, Dosquet C, et al. (Comité d’éthique de l’Inserm). La recherche sur les embryons et les modèles embryonnaires à usage scientifique (MEUS). 2019. https://inserm.hal.science/CEI/inserm-02111023v1 [Google Scholar]
  6. Matthews KRW, Wagner DS, Warmflash A. Stem cell-based models of embryos: The need for improved naming conventions. Stem Cell Rep. 2021 ; 16 : 1014–20. [Google Scholar]
  7. Agence de la biomédecine. Avis du Conseil d’orientation : les modèles embryonnaires. Paris : Agence de biomédecine, 2023. [Google Scholar]
  8. Bioy X, Rial-Sebbag E. Chapitre 3. La gouvernance de la recherche sur l’embryon. J Int Bioéthique Éthique Sci 2017 ; 28 : 55–76. [Google Scholar]
  9. Chneiweiss H, Dubart-Kupperschmitt A, Duclos-Vallée JC, et al. Pour une bonne compréhension et un bon usage du terme « organoïdes ». Med Sci (Paris) 2023 ; 39 : 876–8. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
  10. Desbaillets I, Ziegler U, Groscurth P, et al. Embryoid bodies: An in vitro model of mouse embryogenesis. Exp Physiol 2000 ; 85 : 645–51. [Google Scholar]
  11. Rivron N, Martinez Arias A, Pera MF, et al. An ethical framework for human embryology with embryo models. Cell 2023 ; 186 : 3548–3557. [Google Scholar]
  12. Landecker HL, Clark AT. Human embryo models made from pluripotent stem cells are not synthetic ; they aren’t embryos, either. Cell Stem Cell 2023 ; 30 : 1290–3. [Google Scholar]
  13. Denker H-W. Stem cell terminology and “synthetic” embryos: a new debate on totipotency, omnipotency, and pluripotency and how it relates to recent experimental data. Cells Tissues Organs 2014 ; 199 : 221–7. [Google Scholar]
  14. Tarazi S, Aguilera-Castrejon A, Joubran C, et al. Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs. Cell 2022 ; 185 : 3290–3306.e25. [CrossRef] [PubMed] [Google Scholar]
  15. Wörsdörfer P, Wagner N, Ergün S. The role of connexins during early embryonic development: pluripotent stem cells, gene editing, and artificial embryonic tissues as tools to close the knowledge gap. Histochem Cell Biol 2018 ; 150 : 327–39. [Google Scholar]
  16. Conseil de l’Europe. Protocole additionnel à la Convention pour la protection des Droits de l’Homme et de la dignité de l’être humain à l’égard des applications de la biologie et de la médecine, portant interdiction du clonage d’êtres humains. 1998. Voir https://www.coe.int/fr/web/human-rights-and-biomedicine/oviedo-convention [Google Scholar]
  17. Aach J, Lunshof J, Iyer E, et al. Addressing the ethical issues raised by synthetic human entities with embryo-like features. eLife 2017 ; 6 : e20674. [Google Scholar]
  18. Jordan B. Synthétique, vous avez dit « Synthétique » ? Med Sci (Paris) 2016 ; 32 : 651–3. [Google Scholar]
  19. Veenvliet JV, Lenne P-F, Turner DA, et al. Sculpting with stem cells: how models of embryo development take shape. Development 2021 ; 148 : dev192914. [Google Scholar]
  20. Merle M, Friedman L, Chureau C, et al. Precise and scalable self-organization in mammalian pseudo-embryos. Nat Struct Mol Biol 2023 ; 31, 896–902. [Google Scholar]
  21. Martinez Arias A, Rivron N, Moris N, et al. Criteria for the standardization of stem-cell-based embryo models. Nat Cell Biol 2024 ; 26 : 1625–8. [Google Scholar]
  22. ISSCR. International Society for Stem Cell Research Guidelines for Stem Cell Research and Clinical Translation. 2021; https://www.isscr.org/guidelines. [Google Scholar]
  23. Rivron N, Pera M, Rossant J, et al. Debate ethics of embryo models from stem cells. Nature 2018 ; 564 : 183–5. [Google Scholar]
  24. Ichbiah S, Delbary F, McDougall A, et al. Embryo mechanics cartography: inference of 3D force atlases from fluorescence microscopy. Nat Methods 2023 ; 20 : 1989–99. [Google Scholar]
  25. Cambridge Reproduction. Code of Practice for the generation and use of human stem cell-based embryo models. 2024 : https://www.repro.cam.ac.uk/scbemcode. [Google Scholar]
  26. Clark A, Cook-Andersen H, Franklin S, et al. Stem cell-based embryo models: The 2021 ISSCR stem cell guidelines revisited. Stem Cell Rep 2025 ; 20 : 102514 [Google Scholar]
  27. Denker H-W. Embryoids, models, embryos? We need to take a new look at legal norms concerning the beginning of organismic development. Mol Hum Reprod 2024 ; 30 : gaad047. [Google Scholar]
  28. Pereira Daoud AM, Popovic M, Dondorp WJ, et al. Modelling human embryogenesis: embryo-like structures spark ethical and policy debate. Hum Reprod Update 2020 ; 26 : 779–98. [Google Scholar]

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