Open Access
Issue
Med Sci (Paris)
Volume 41, Number 11, Novembre 2025
Page(s) 869 - 876
Section M/S Revues
DOI https://doi.org/10.1051/medsci/2025185
Published online 12 December 2025
  1. Chen C, Haupert SR, Zimmermann L, et al. Global prevalence of post-coronavirus disease 2019 (COVID-19) condition or long COVID: a meta-analysis and systematic review. J Infect Dis 2022 ; 226 :1593–607. [Google Scholar]
  2. Al-Aly Z, Rosen C. J. Long covid and impaired cognition—more evidence and more work to do. N Engl J Med 2024 ; 390 : 858–60. [Google Scholar]
  3. Scurati R, Papini N, Giussani P, et al. The challenge of Long COVID-19 management: from disease molecular hallmarks to the proposal of exercise as therapy. IJMS 2022 ; 23 : 12311. [Google Scholar]
  4. Bowe B, Xie Y, Al-Aly Z. Postacute sequelae of COVID-19 at 2 years. Nat Med 2023 ; 29 : 2347–57. [Google Scholar]
  5. Rahmati M, Udeh R, Yon DK, et al. A systematic review and meta-analysis of long-term sequelae of COVID-19 2-year after SARS-CoV-2 infection: A call to action for neurological, physical, and psychological sciences. J Med Vir 2023 ; 95 : e28852. [Google Scholar]
  6. Kozłowski P, Leszczyn ΄ska A, Ciepiela O. Long COVID definition, symptoms, risk factors, epidemiology and autoimmunity: a narrative review. AJM Open 2024 ; 11:100068. [Google Scholar]
  7. Callard F, Perego E. How and why patients made Long Covid. Soc Sci Med 2021 ; 268 : 113426. [Google Scholar]
  8. Pasini E, Corsetti G, Romano C, et al. Serum Metabolic Profile in Patients With Long-Covid (PASC) Syndrome: Clinical Implications. Front Med 2021; 22 ; 8:714426. [Google Scholar]
  9. Altmann DM, Whettlock EM, Liu S, et al. The immunology of long COVID. Nat Rev Immunol 2023 ; 3 :618–34. [Google Scholar]
  10. Davis HE, McCorkell L, Vogel JM, et al. Long COVID: major findings, mechanisms and recommendations. Nat Rev Microbiol 2023 ; 21:133–46. [CrossRef] [PubMed] [Google Scholar]
  11. Wei X, Qian W, Narasimhan H, et al. Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae. Science 2025 ; 387: eadq2509. [Google Scholar]
  12. Sariol A & Perlman S. Lung inflammation drives Long Covid. Science 2025 ; 387 : 1039–40. [Google Scholar]
  13. Fekete M, Lehoczki A, Szappanos Á, et al. Cerebromicrovascular mechanisms contributing to long COVID: implications for neurocognitive health. GeroScience 2025 1–35. [Google Scholar]
  14. Zhang L, Huang T, He H, et al. Unraveling the molecular mechanisms of Ace2-mediated post-COVID-19 cognitive dysfunction through systems genetics approach. Exp Neurol 2024 ; 381: 114921. [Google Scholar]
  15. Malioukis A, Snead R S, Marczika J, et al. Pathophysiological, neuropsychological, and psychosocial influences on neurological and neuropsychiatric symptoms of post-acute covid-19 syndrome: impacts on recovery and symptom persistence. Biomedicines 2024 ; 12 : 2831. [Google Scholar]
  16. Titze-de-Almeida R, Lacerda PHA, de Oliveira EP, et al. Sleep and memory complaints in long COVID: An insight into clustered psychological phenotypes. PeerJ 2024. 12, e16669. [Google Scholar]
  17. Popa E, Popa A E, Poroch M, et al. The molecular mechanisms of cognitive dysfunction in long covid: a narrative Review. Inter J Mol Sci 2025 ; 26: 5102. [Google Scholar]
  18. Panagea E, Messinis L, Petri M C, et al. Neurocognitive impairment in long COVID: a systematic review. Arch Clin Neuropsy 2025; 40 : 125–49. [Google Scholar]
  19. Plant AN, Rasheed AZ, Hasan M. Long COVID and the brain: a retrospective study of the neuropsychological manifestations of Long COVID. COVID 2025; 5(5): 65. [Google Scholar]
  20. Fekete R, Simats A, Bíró E, et al. Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1-and IL-6-related systemic inflammation in COVID-19. Nat Neurosci 2025; 1–19. [Google Scholar]
  21. Kumar S, Bhatia Z, Seshadri S. Microbiome and mycobiome cross-talk from an immunobiotic perspective in COVID-19 and post-acute COVID-19 syndrome. Exp Immuno 2025 ; 5:1003182. [Google Scholar]
  22. Zhang D, Zhou Y, Ma Y, et al. Gut microbiota dysbiosis correlates with long COVID-19 at one-year after discharge. Korean Med 2023; 38: e120. [Google Scholar]
  23. Qiu Y, Mo C, Chen L, et al. Alterations in microbiota of patients with COVID-19: implications for therapeutic interventions. Med Comm 2024; 5: e513. [Google Scholar]
  24. Piazzesi A, Pane S, Del Chierico F, et al. The pediatric gut bacteriome and virome in response to sars-cov-2 infection. Front Cell Infect Microbiol 2024 ; 14:1335450. [Google Scholar]
  25. Barichello T, Kluwe-Schiavon B, Borba LA, et al. Alterations in Gut Microbiome Composition and Increased Inflammatory Markers in Post-COVID-19 Individuals. Mol Neurobio 2025; 1–10. [Google Scholar]
  26. Yousef M, Rob M, Varghese S, et al. The effect of microbiome therapy on COVID-19-induced gut dysbiosis: A narrative and systematic review. Life Sci 2024, 122535. [Google Scholar]
  27. Lupi L, Vitiello A, Parolin C, et al. The potential role of viral persistence in the post-acute sequelae of SARS-CoV-2 infection (PASC). Pathogens 2024; 13: 388. [Google Scholar]
  28. Gheorghita R, Soldanescu I, Lobiuc A, et al. The knowns and unknowns of long COVID-19: from mechanisms to therapeutical approaches. Front Immunol 2024 ; 15: 1344086. [Google Scholar]
  29. Peluso M J, Deeks S G. Mechanisms of long COVID and the path toward therapeutics. Cell 2024; 187: 5500–29. [Google Scholar]
  30. Molnar T, Lehoczki A, Fekete M, et al. Mitochondrial dysfunction in long COVID: mechanisms, consequences, and potential therapeutic approaches. Geroscience 2024; 46: 5267–86. [Google Scholar]
  31. Polli A, Godderis L, Martens D S, et al. Exploring DNA methylation, telomere length, mitochondrial DNA, and immune function in patients with Long-COVID. BMC Med 2025 ; 23: 60. [Google Scholar]
  32. Majima H J, Chatatikun M, Indo H P, et al. Lipidated COVID-19 localizes into mitochondria and causes oxidative damage to mitochondrial dna–pathophysiology of long COVID. Med Res Arch 2025; 13. [Google Scholar]
  33. Gusev E, Sarapultsev A. Exploring the pathophysiology of Long COVID: the central role of low-grade inflammation and multisystem involvement. Inter J Mol Sci 2024; 25: 6389. [Google Scholar]
  34. Kell DB, Khan MA, Kane B, et al. Possible role of fibrinaloid microclots in postural orthostatic tachycardia syndrome (POTS): focus on Long COVID. J Pers Med 2024;14. [Google Scholar]
  35. Beltrán-García J, Osca-Verdegal R, Pallardó FV, et al. Sepsis and coronavirus disease 2019: common features and anti-inflammatory therapeutic approaches. Critical Care Med 2020; 48:1841–4. [Google Scholar]
  36. Zhang S, Chang W, Xie J, et al. The efficacy, safety, and optimal regimen of corticosteroids in sepsis: a bayesian network meta-analysis. Critical Care Expl 2020 ; 2 :e0094. [Google Scholar]
  37. Brenner EJ, Ungaro RC, Gearry RB, et al. Corticosteroids, but not TNF antagonists, are associated with adverse covid-19 outcomes in patients with inflammatory bowel diseases: results from an international registry. Gastroenterology 2020 ; 159 :481–91. [Google Scholar]
  38. Gianfrancesco M, Hyrich KL, Al-Adely S, et al. Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry. Ann Rheum Dis 2020 ;79 :859–66. [Google Scholar]
  39. Schultze A, Walker AJ, MacKenna B, et al. Risk of COVID-19-related death among patients with chronic obstructive pulmonary disease or asthma prescribed inhaled corticosteroids: an observational cohort study using the OpenSAFELY platform. Lancet Respir Med 2020 ; 8 :1106–20. [Google Scholar]
  40. Milne, A., Maskell, S., Sharp, C., Hamilton, F. W., & Arnold, D. T. (2021). Impact of dexamethasone on persistent symptoms of COVID-19: an observational study. medRxiv ; 2021-11. [Google Scholar]
  41. Proal AD, Aleman S, Bomsel M, et al. Targeting the SARS-CoV-2 reservoir in long COVID. Lancet Infec Dis 2025. [Google Scholar]
  42. Stein SR, Ramelli SC, Grazioli A. et al. SARS-CoV-2 infection and persistence in the human body and brain at autopsy. Nature 2022; 612: 758–63. [Google Scholar]
  43. Chakraborty C, Bhattacharya M. The current landscape of long COVID clinical trials: NIH’s RECOVER to Stanford Medicine’s STOP-PASC initiative. Mol Ther Nucleic Acids 2023 ; 33:887–9. [Google Scholar]
  44. Choi YJ, Seo YB, Seo JW, et al. Effectiveness of antiviral therapy on Long COVID: a systematic review and meta-analysis. JCM 2023 ;12:7375. [Google Scholar]
  45. Catalán I P, Buj A G, Muñoz S G, et al. Nirmatrelvir/ritonavir as a possible treatment for Long-COVID. Rev Esp Quim 2023; 36: 545. [Google Scholar]
  46. Durstenfeld M S, Peluso MJ, Lin F, et al. Association of nirmatrelvir for acute SARS-CoV-2 infection with subsequent Long COVID symptoms in an observational cohort study. J Med Viro 2024 ; 96: e29333 [Google Scholar]
  47. Nair M S, Luck M I, Huang Y, et al. Persistence of an infectious form of SARS-CoV-2 post protease inhibitor treatment of permissive cells in vitro. bioRxiv 2023. [Google Scholar]
  48. Ramacciotti E, Barile Agati L, Calderaro D, et al. Rivaroxaban versus no anticoagulation for post-discharge thromboprophylaxis after hospitalisation for COVID-19 (MICHELLE): an open-label, multicentre, randomised, controlled trial. Lancet 2022 ; 399 : 50–9. [Google Scholar]
  49. Tang N, Bai H, Chen X, et al. Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. J Throm aemostasis 2020 ;18 :1094–9. [Google Scholar]
  50. Connors JM, Ariëns RAS. Uncertainties about the roles of anticoagulation and microclots in postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection. J Throm Haemo 2023 ; 21 : 2697–701. [Google Scholar]
  51. McCarthy MW. Intravenous immunoglobulin as a potential treatment for long COVID. Exp Opin Biol Ther 2023 ; 23 :1211–7. [Google Scholar]
  52. Morse BA, Motovilov K, Michael Brode W, et al. A review of intravenous immunoglobulin in the treatment of neuroimmune conditions, acute COVID-19 infection, and post-acute sequelae of COVID-19 Syndrome. Brain Behav Immun 2025 ;123:725–38. [Google Scholar]
  53. Svačina MKR, Sprenger-Svačina A, Tsakmaklis A, et al. The gut microbiome in intravenous immunoglobulin-treated chronic inflammatory demyelinating polyneuropathy. Euro J Neuro 2023 ; 30 : 3551–6. [Google Scholar]
  54. Seibert FS, Stervbo U, Wiemers L, et al. Severity of neurological Long-COVID symptoms correlates with increased level of autoantibodies targeting vasoregulatory and autonomic nervous system receptors. Autoimmun reviews 2023; 22: 103445. [Google Scholar]
  55. Vitari N, Roy S. Intestinal immunoglobulins under microbial dysbiosis: implications in opioid-induced microbial dysbiosis. Front Microbiol 2025; 16:1580661. [Google Scholar]
  56. Scheppke KA, Pepe PE, Jui J, et al. Remission of severe forms of long COVID following monoclonal antibody (MCA) infusions: A report of signal index cases and call for targeted research. Amer J Emer Med 2024 ;75:122–7. [Google Scholar]
  57. Muyldermans S. Nanobodies: natural single-domain antibodies. Ann Rev Biochem 2013 ; 82 : 775–97. [Google Scholar]
  58. Rissiek, B., Koch-Nolte, F., Magnus, T. Nanobodies as modulators of inflammation: potential applications for acute brain injury. Front Cell Neurosci 2014 ; 8 : 344. [Google Scholar]
  59. Alexander E, Leong K W. Discovery of nanobodies: a comprehensive review of their applications and potential over the past five years. J Nanobiotech 2024; 22: 661. [Google Scholar]
  60. Rossotti MA, Bélanger K, Henry KA, et al. Immunogenicity and humanization of single-899 domain antibodies. FEBS J 2022 ; 289: 4304–27. [Google Scholar]
  61. Yu T, Zheng F, He W, et al. Single domain antibody: Development and application in biotechnology and biopharma. Immunol Rev 2024; 328: 98–112. [Google Scholar]
  62. Colas C, Le Berre Y, Fanget M, et al. Physical activity in Long COVID: a comparative study of exercise rehabilitation benefits in patients with Long COVID, coronary artery disease and fibromyalgia. IJERPH 2023 ; 20 : 6513. [Google Scholar]
  63. Gloeckl R, Zwick RH, Fürlinger U, et al. Practical recommendations for exercise training in patients with Long COVID with or without post-exertional malaise: a best practice proposal. Sports Med - Open 2024 ; 10 :47. [Google Scholar]
  64. Nopp S, Moik F, Klok FA, et al. Outpatient pulmonary rehabilitation in patients with Long COVID improves exercise capacity, functional status, dyspnea, fatigue, and quality of life. Respiration 2022 ; 101:593–601. [Google Scholar]
  65. Ghali A, Lacombe V, Ravaiau C, et al. The relevance of pacing strategies in managing symptoms of post-COVID-19 syndrome. J Trans Med 2023; 21: 375. [Google Scholar]
  66. Giovanetti M, Pannella G, Altomare A, et al. Exploring the interplay between COVID-19 and gut health: the potential role of prebiotics and probiotics in immune support. Viruses 2024 ; 16 : 370. [Google Scholar]
  67. Morello R, De Rose C, Cardinali S, et al. Lactoferrin as possible treatment for chronic gastrointestinal symptoms in children with Long COVID: case series and literature review. Children 2022 ; 9 :1446. [Google Scholar]
  68. Soltani R, Alikiaie B, Shafiee F, et al. Coenzyme Q10 improves the survival and reduces inflammatory markers in septic patients. BLL 2021;121:154–8. [Google Scholar]
  69. Kim, T. H., Yoon, J., Kim, S., Kang, B. K., Kang, J. W., Kwon, S. Herbal medicines for long COVID: A phase 2 pilot clinical study. Heliyon 2024 ; 10. [Google Scholar]
  70. Nikhat S, Fazil M. Shortening the long-COVID: An exploratory review on the potential of Unani medicines in mitigating post-Covid-19 sequelae. Phytomed Plus 2024 ; 4:100570. [Google Scholar]
  71. Feng BW, Rong PJ. Acupoint stimulation for long COVID: A promising intervention. World J Acupunc - Moxibustion 2023 ; 33 :191–7. [Google Scholar]
  72. Sum CH, Ching JYL, Song T, et al. Chinese medicine for residual symptoms of COVID-19 recovered patients (long COVID)—A double-blind, randomized, and placebo-controlled clinical trial protocol. Front Med 2023 ; 9 : 990639. [Google Scholar]
  73. Ying X, Jing Z, Yang Y, et al. Investigation of the potential molecular mechanisms of acupuncture in thetreatment of long COVID: a bioinformatics approach. Cell Mol Biol 2024 ; 70 :193–200. [Google Scholar]
  74. Algitany S, Fouad S, Nassif A, et al. The effect of laser acupuncture on immunomodulation and dyspnea in post-COVID-19 patients. areh 2023 ; 37:33–9. [Google Scholar]
  75. Vogel J, Pollack B, Spier E, et al. Designing and optimizing clinical trials for long COVID. Life Sci 2024. 122970. [Google Scholar]
  76. Krumholz HM, Sawano M, Bhattacharjee B, et al. The PAX LC trial: a decentralized, phase 2, randomized, double-blind study of nirmatrelvir/ritonavir compared with placebo/ritonavir for long COVID. Am J Med 2025 ; 138 : 884–92. [Google Scholar]

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