Open Access
Issue
Med Sci (Paris)
Volume 41, Number 11, Novembre 2025
Page(s) 842 - 844
Section Nouvelles
DOI https://doi.org/10.1051/medsci/2025212
Published online 12 December 2025
  1. Gusella JF, Lee JM, MacDonald ME. Huntington’s disease: nearly four decades of human molecular genetics. Hum Mol Genet 2021 ; 30 : R254-R63. [Google Scholar]
  2. Bates GP, Dorsey R, Gusella JF, et al. Huntington disease. Nat Rev Dis Primers 2015 ; 1 : 15005. [Google Scholar]
  3. Tabrizi SJ, Flower MD, Ross CA, Wild EJ. Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities. Nat Rev Neurol 2020 ; 16 : 529–46. [Google Scholar]
  4. Cattaneo E, Scalzo D, Zobel M, et al. When repetita no-longer iuvant: somatic instability of the CAG triplet in Huntington’s disease. Nucleic Acids Res 2025 ; 53 : gkae1204.. [Google Scholar]
  5. Pearson CE, Nichol Edamura K, Cleary JD. Repeat instability: mechanisms of dynamic mutations. Nat Rev Genet 2005 ; 6 : 729–42. [CrossRef] [PubMed] [Google Scholar]
  6. Mouro Pinto R, Arning L, Giordano JV, et al. Patterns of CAG repeat instability in the central nervous system and periphery in Huntington’s disease and in spinocerebellar ataxia type 1. Hum Mol Genet 2020 ; 29 : 2551–67. [Google Scholar]
  7. Genetic modifiers of Huntington’s disease (GeM-HD) consortium. CAG repeat, not polyglutamine length, determines timing of Huntington’s disease onset. Cell 2019 ; 178 : 887-900 e14. [CrossRef] [PubMed] [Google Scholar]
  8. Handsaker RE, Kashin S, Reed NM, et al. Long somatic DNA-repeat expansion drives neurodegeneration in Huntington’s disease. Cell 2025 ; 188 : 623-39 e19. [CrossRef] [PubMed] [Google Scholar]
  9. Wang N, Zhang S, Langfelder P, et al. Distinct mismatch-repair complex genes set neuronal CAG-repeat expansion rate to drive selective pathogenesis in HD mice. Cell 2025 ; 188 : 1524-44 e22. [Google Scholar]
  10. Brulé B, Alcala-Vida R, Penaud N, et al. Accelerated epigenetic aging in Huntington’s disease involves polycomb repressive complex 1. Nat Commun 2025 ; 16 : 1550. [Google Scholar]
  11. Atlasi Y, Stunnenberg HG. The interplay of epigenetic marks during stem cell differentiation and development. Nat Rev Genet 2017 ; 18 : 643–58. [CrossRef] [PubMed] [Google Scholar]
  12. Yang JH, Hayano M, Griffin PT, et al. Loss of epigenetic information as a cause of mammalian aging. Cell 2023 ; 186 : 305-26 e27. [CrossRef] [PubMed] [Google Scholar]
  13. Bonev B, Castelo-Branco G, Chen F, et al. Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery. Nat Neurosci 2024 ; 27 : 2292–309. [Google Scholar]
  14. Stricker SH, Koferle A, Beck S. From profiles to function in epigenomics. Nat Rev Genet 2017 ; 18 : 51–66. [Google Scholar]

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