Open Access
Issue
Med Sci (Paris)
Volume 36, Number 1, Janvier 2020
Page(s) 12 - 15
Section Le Magazine
DOI https://doi.org/10.1051/medsci/2019253
Published online 04 February 2020
  1. The Huntington’s Disease Collaborative Research Group A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes. Cell 1993 ; 72 : 971–983. [Google Scholar]
  2. Vonsattel JP Myers R H Stevens TJ et al. Neuropathological classification of Huntington’s disease. J Neuropathol Exp Neurol 1985 ; 44 : 559–577. [CrossRef] [PubMed] [Google Scholar]
  3. Ross CA Tabrizi SJ Huntington’s disease: from molecular pathogenesis to clinical treatment. Lancet Neurol 2011 ; 10 : 83–98. [CrossRef] [PubMed] [Google Scholar]
  4. Roze E Saudou F Caboche J Pathophysiology of Huntington’s disease: from huntingtin functions to potential treatments. Curr Opin Neurol 2008 ; 21 : 497–503. [CrossRef] [PubMed] [Google Scholar]
  5. Karasinska JM Hayden MR Cholesterol metabolism in Huntington disease. Nat Rev Neurol 2011 ; 7 : 561–572. [CrossRef] [PubMed] [Google Scholar]
  6. Leoni V Mariotti C Tabrizi SJ et al. Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington’s disease. Brain 2008 ; 131 : 2851–2859. [CrossRef] [PubMed] [Google Scholar]
  7. Valenza M Chen JY Di Paolo E et al. Cholesterol-loaded nanoparticles ameliorate synaptic and cognitive function in Huntington’s disease in mice. EMBO Mol Med 2005 ; 7 : 1547–1564. [Google Scholar]
  8. Boussicault L Alves S Lamaziere A et al. CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington’s disease. Brain 2016 ; 139 : 953–970. [CrossRef] [PubMed] [Google Scholar]
  9. Kacher R Lamaziere A Heck N et al. CYP4A1 gene therapy deciphers the role of brain cholesterol metabolism in Huntington’s disease. Brain 2019 ; 142 : 2432–2450. [CrossRef] [PubMed] [Google Scholar]
  10. Hudry E Van Dam D Kulik W et al. Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer’s disease. Mol Ther 2010 ; 18 : 44–53. [CrossRef] [PubMed] [Google Scholar]
  11. Durr A. Thérapie par ARN anti-sens dans la maladie de Huntington : un immense espoir et beaucoup d’inconnues. Med Sci (Paris) 2019 ; 35 : 834–836. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]

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