SUMO régule la capacité de TRIM5α à inhiber le VIH-1

Sébastien Nisole; Juliette Fernandez; Ghizlane Maarifi; Nathalie J. Arhel

doi:10.1051/medsci/2019016

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Volume 35 / No 2 (Février 2019)

Med Sci (Paris), 35 2 (2019) 106-109

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Issue		Med Sci (Paris) Volume 35, Number 2, Février 2019


Page(s)		106 - 109
Section		Le Magazine
DOI		https://doi.org/10.1051/medsci/2019016
Published online		18 February 2019

Soliman M, Srikrishna G, Balagopal A. Mechanisms of HIV-1 control. Curr HIV/AIDS Rep 2017 ; 14 : 101–109. [Google Scholar]
Chougui G, Martin M, Matkovic R, et al. Vpx n’a pas dit son dernier mot : « Hush ! ». Med Sci (Paris) 2019 ; 35 : 9–12. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
Stremlau M, Perron M, Lee M, et al. Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor. Proc Natl Acad Sci USA 2006 ; 103 : 5514–5519. [CrossRef] [Google Scholar]
Stremlau M, Owens CM, Perron MJ, et al. The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in old world monkeys. Nature 2004 ; 427 : 848–853. [CrossRef] [PubMed] [Google Scholar]
Bourke NM, Napoletano S, Bannan C, et al. Control of HIV infection by IFN-alpha: implications for latency and a cure. Cell Mol Life Sci 2018 ; 75 : 775–783. [CrossRef] [PubMed] [Google Scholar]
Cribier A, Descours B, Valadao AL, et al. Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1. Cell Rep 2013 ; 3 : 1036–1043. [CrossRef] [PubMed] [Google Scholar]
Flotho A, Melchior F. Sumoylation: a regulatory protein modification in health and disease. Annu Rev Biochem 2013 ; 82 : 357–385. [CrossRef] [PubMed] [Google Scholar]
Dutrieux J, Portilho DM, Arhel NJ, et al. TRIM5alpha is a SUMO substrate. Retrovirology 2015 ; 12 : 28. [CrossRef] [PubMed] [Google Scholar]
Portilho DM, Fernandez J, Ringeard M, et al. Endogenous TRIM5alpha function Is regulated by SUMOylation and nuclear sequestration for efficient innate sensing in dendritic cells. Cell Rep 2016 ; 14 : 355–369. [CrossRef] [PubMed] [Google Scholar]
Maarifi G, Fernandez J, Portilho DM, et al. RanBP2 regulates the anti-retroviral activity of TRIM5α by SUMOylation at a predicted phosphorylated SUMOylation motif. Commun Biol 2018 ; 1 : 193. [PubMed] [Google Scholar]
Di Nunzio F, Danckaert A, Fricke T, et al. Human nucleoporins promote HIV-1 docking at the nuclear pore, nuclear import and integration. PloS One 2012 ; 7 : e46037. [CrossRef] [PubMed] [Google Scholar]
Werner A, Flotho A, Melchior F. The RanBP2/RanGAP1*SUMO1/Ubc9 complex is a multisubunit SUMO E3 ligase. Mol Cell 2012 ; 46 : 287–298. [CrossRef] [PubMed] [Google Scholar]
Arhel NJ, Nisole S, Carthagena L, et al. Lack of endogenous TRIM5alpha-mediated restriction in rhesus macaque dendritic cells. Blood 2008 ; 112 : 3772–3776. [Google Scholar]

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[1] Soliman M, Srikrishna G, Balagopal A. Mechanisms of HIV-1 control. Curr HIV/AIDS Rep 2017 ; 14 : 101–109. [Google Scholar]

[2] Chougui G, Martin M, Matkovic R, et al. Vpx n’a pas dit son dernier mot : « Hush ! ». Med Sci (Paris) 2019 ; 35 : 9–12. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]

[3] Stremlau M, Perron M, Lee M, et al. Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor. Proc Natl Acad Sci USA 2006 ; 103 : 5514–5519. [CrossRef] [Google Scholar]

[4] Stremlau M, Owens CM, Perron MJ, et al. The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in old world monkeys. Nature 2004 ; 427 : 848–853. [CrossRef] [PubMed] [Google Scholar]

[5] Bourke NM, Napoletano S, Bannan C, et al. Control of HIV infection by IFN-alpha: implications for latency and a cure. Cell Mol Life Sci 2018 ; 75 : 775–783. [CrossRef] [PubMed] [Google Scholar]

[6] Cribier A, Descours B, Valadao AL, et al. Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1. Cell Rep 2013 ; 3 : 1036–1043. [CrossRef] [PubMed] [Google Scholar]

[7] Flotho A, Melchior F. Sumoylation: a regulatory protein modification in health and disease. Annu Rev Biochem 2013 ; 82 : 357–385. [CrossRef] [PubMed] [Google Scholar]

[8] Dutrieux J, Portilho DM, Arhel NJ, et al. TRIM5alpha is a SUMO substrate. Retrovirology 2015 ; 12 : 28. [CrossRef] [PubMed] [Google Scholar]

[9] Portilho DM, Fernandez J, Ringeard M, et al. Endogenous TRIM5alpha function Is regulated by SUMOylation and nuclear sequestration for efficient innate sensing in dendritic cells. Cell Rep 2016 ; 14 : 355–369. [CrossRef] [PubMed] [Google Scholar]

[10] Maarifi G, Fernandez J, Portilho DM, et al. RanBP2 regulates the anti-retroviral activity of TRIM5α by SUMOylation at a predicted phosphorylated SUMOylation motif. Commun Biol 2018 ; 1 : 193. [PubMed] [Google Scholar]

[11] Di Nunzio F, Danckaert A, Fricke T, et al. Human nucleoporins promote HIV-1 docking at the nuclear pore, nuclear import and integration. PloS One 2012 ; 7 : e46037. [CrossRef] [PubMed] [Google Scholar]

[12] Werner A, Flotho A, Melchior F. The RanBP2/RanGAP1*SUMO1/Ubc9 complex is a multisubunit SUMO E3 ligase. Mol Cell 2012 ; 46 : 287–298. [CrossRef] [PubMed] [Google Scholar]

[13] Arhel NJ, Nisole S, Carthagena L, et al. Lack of endogenous TRIM5alpha-mediated restriction in rhesus macaque dendritic cells. Blood 2008 ; 112 : 3772–3776. [Google Scholar]