Free Access
Med Sci (Paris)
Volume 34, Number 4, Avril 2018
Page(s) 288 - 291
Section Le Magazine
Published online 16 April 2018
  1. GDB 2015 obesity collaborators. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med 2017; 377 : 13-27. [Google Scholar]
  2. Vatier C, Capeau J, Vigouroux C. La leptine, nouvelle perspective thérapeutique dans le traitement du diabète ? Med Sci (Paris) 2010; 26 : 803-7. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
  3. Farooqi IS, Jebb SA, Langmack G, et al., Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 1999; 341 : 879-84. [Google Scholar]
  4. Roujeau C, Jockers R, Dam J. New pharmacological perspectives for the leptin receptor in the treatment of obesity. Front Endocrinol (Lausanne) 2014; 5 : 167. [PubMed] [Google Scholar]
  5. Dehouck B, Prévot V, Langlet F. Plasticité de la barrière hémato-hypothalamique. Rôle dans l’homéostasie énergétique. Med Sci (Paris) 2014; 30 : 627-30. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
  6. Bates SH, Stearns WH, Dondon TA, et al., STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 2003; 421 : 856-9. [CrossRef] [PubMed] [Google Scholar]
  7. Morton GJ, Gelling RW, Niswender KD, et al., Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab 2005; 2 : 411-20. [CrossRef] [PubMed] [Google Scholar]
  8. Couturier C, Sarkis C, Séron K et al., Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity. Proc Natl Acad Sci USA 2007; 104 : 19476-81. [CrossRef] [Google Scholar]
  9. Séron K, Couturier C, Belouzard S, et al., Endospanins regulate a postinternalization step of the leptin receptor endocytic pathway. J Biol Chem 2011; 286 : 17968-81. [CrossRef] [PubMed] [Google Scholar]
  10. Vauthier V, Swartz TD, Chen P, et al., Endospanin 1 silencing in the hypothalamic arcuate nucleus contributes to sustained weight loss of high fat diet obese mice. Gene Ther 2014; 7 : 638-44. [Google Scholar]
  11. Vauthier V, Roujeau C, Chen P, et al., Endospanin1 affects oppositely body weight regulation and glucose homeostasis by differentially regulating central leptin signaling. Mol Metab 2016; 6 : 159-72. [CrossRef] [PubMed] [Google Scholar]

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