Free Access
Issue
Med Sci (Paris)
Volume 33, Number 3, Mars 2017
Autophagie
Page(s) 319 - 327
Section M/S Revues
DOI https://doi.org/10.1051/medsci/20173303020
Published online 03 April 2017
  1. Van Bavel CC, Dieker JW, Kroeze Y, et al. Apoptosis-induced histone H3 methylation is targeted by autoantibodies in systemic lupus erythematosus. Ann Rheum Dis 2011 ; 70 : 201–207. [CrossRef] [PubMed] [Google Scholar]
  2. Dieker JW, Iglesias-Guimarais V, Décossas M, et al. Early apoptotic reorganization of spliceosomal proteins involves caspases. CAD and rearrangement of NuMA. Traffic 2012 ; 13 : 257–272. [Google Scholar]
  3. Muller S, Radic M. Oxidation and mitochondrial origin of NET DNA in the pathogenesis of lupus. Nature Med 2016 ; 22 : 126–127. [CrossRef] [Google Scholar]
  4. Lehmann PV, Forsthuber T, Miller A, Sercarz EE. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature 1992 ; 358 : 155–157. [CrossRef] [PubMed] [Google Scholar]
  5. Vanderlugt CL, Miller SD. Epitope spreading in immune-mediated diseases : implications for immunotherapy. Nat Rev Immunol 2002 ; 2 : 85–95. [CrossRef] [PubMed] [Google Scholar]
  6. Monneaux F, Muller S. Epitope spreading in systemic lupus erythematosus : identification of triggering peptide sequences. Arthritis Rheum 2002 ; 46 : 1430–1438. [CrossRef] [PubMed] [Google Scholar]
  7. Monneaux F, Parietti V, Briand JP, Muller S. Importance of spliceosomal RNP1 motif for intermolecular T-B cell spreading and tolerance restoration in lupus. Arthritis Res Ther 2007 ; 9 : R111. [CrossRef] [PubMed] [Google Scholar]
  8. Feng Y, He D, Yao Z, Klionsky DJ. The machinery of macroautophagy. Cell Res 2014 ; 24 : 24–41. [CrossRef] [PubMed] [Google Scholar]
  9. Subramani S, Malhotra V. Non-autophagic roles of autophagy-related proteins. EMBO Rep 2013 ; 14 : 143–151. [CrossRef] [PubMed] [Google Scholar]
  10. Arnold J, Murera D, Arbogast F, et al. L’autophagie et l’homéostasie des LT et B : bien recycler pour un développement durable. Med Sci (Paris) 2016 ; 32 : 281–289. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
  11. Valdor R, Mocholi E, Botbol Y, et al. Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation. Nat Immunol 2014 ; 15 : 1046–1054. [CrossRef] [PubMed] [Google Scholar]
  12. Botbol Y, Guerrero-Ros I, Macian F. Key roles of autophagy in regulating T-cell function. Eur J Immunol 2016 ; 46 : 1326–1334. [CrossRef] [PubMed] [Google Scholar]
  13. Pua HH, Dzhagalov I, Chuck M, et al. A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med 2007 ; 204 : 25–31. [CrossRef] [PubMed] [Google Scholar]
  14. Stephenson LM, Miller BC, Ng A, et al. Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes. Autophagy 2009 ; 5 : 625–635. [CrossRef] [PubMed] [Google Scholar]
  15. Deretic V, Saitoh T, Akira S. Autophagy in infection, inflammation and immunity. Nat Rev Immunol 2013 ; 13 : 722–737. [CrossRef] [PubMed] [Google Scholar]
  16. Ma Y, Galluzzi L, Zitvogel L, Kroemer G. Autophagy and cellular immune responses. Immunity 2013 ; 39 : 211–227. [CrossRef] [Google Scholar]
  17. Gros F, Muller S. Pharmacological regulators of autophagy and their link with modulators of lupus disease. Brit. J. Pharmacol. 2014 ; 171 : 4337–4359. [CrossRef] [Google Scholar]
  18. Arnold J, Murera D, Arbogast F, et al. Autophagy is dispensable for B cell development but essential for humoral autoimmune responses. Cell Death Differ 2016 ; 23 : 853–864. [CrossRef] [PubMed] [Google Scholar]
  19. Harley JB, Alarcon-Riquelme ME, Criswell LA, et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet 2008 ; 40 : 204–210. [CrossRef] [PubMed] [Google Scholar]
  20. Han JW, Zheng HF, Cui Y, et al. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet 2009 ; 41 : 1234–1237. [CrossRef] [PubMed] [Google Scholar]
  21. Lessard CJ, Sajuthi S, Zhao J, et al. Identification of a Systemic lupus erythematosus risk locus spanning ATG16L2, FCHSD2, and P2RY2 in Koreans. Arthritis Rheum 2016 ; 68 : 1197–1209. [Google Scholar]
  22. Gros F, Arnold J, Page N, et al. Macroautophagy is deregulated in murine and human lupus T lymphocytes. Autophagy 2012 ; 8 : 1113–1123. [CrossRef] [PubMed] [Google Scholar]
  23. Alessandri C, Barbati C, Vacirca D, et al. T lymphocytes from patients with systemic lupus erythematosus are resistant to induction of autophagy. FASEB J 2012 ; 26 : 4722–4732. [CrossRef] [PubMed] [Google Scholar]
  24. Clarke AJ, Ellinghaus U, Cortini A, et al. Autophagy is activated in systemic lupus erythematosus and required for plasmablast development. Ann Rheum Dis 2015 ; 74 : 912–920. [CrossRef] [PubMed] [Google Scholar]
  25. Mizushima N, Yoshimori T, Levine B. Methods in mammalian autophagy research. Cell 2010 ; 140 : 313–326. [CrossRef] [PubMed] [Google Scholar]
  26. Klionsky DJ, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2016 ; 12 : 1–222. [CrossRef] [PubMed] [Google Scholar]
  27. Cuervo AM, Wong E. Chaperone-mediated autophagy : roles in disease and aging. Cell Res 2014 ; 24 : 92–104. [CrossRef] [PubMed] [Google Scholar]
  28. Macri C, Wang F, Tasset I, et al. Modulation of deregulated chaperone-mediated autophagy by a phosphopeptide. Autophagy 2015 ; 11 : 472–486. [CrossRef] [PubMed] [Google Scholar]
  29. Nedjic J, Aichinger M, Emmerich J, et al. Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance. Nature 2008 ; 455 : 396–400. [CrossRef] [PubMed] [Google Scholar]
  30. Dengjel J, Schoor O, Fischer R, et al. Autophagy promotes MHC class II presentation of peptides from intracellular source proteins. Proc Natl Acad Sci USA 2005 ; 102 : 7922–7927. [CrossRef] [Google Scholar]
  31. Münz C. Autophagy proteins in antigen processing for presentation on MHC molecules. Immunol Rev 2016 ; 272 : 17–27. [CrossRef] [PubMed] [Google Scholar]
  32. Deffit SN, Blum JS. A central role for HSC70 in regulating antigen trafficking and MHC class II presentation. Mol Immunol 2015 ; 68 : 85–88. [CrossRef] [PubMed] [Google Scholar]
  33. Roche PA, Furuta K. The ins and outs of MHC class II-mediated antigen processing and presentation. Nat Rev Immunol 2015 ; 15 : 203–216. [CrossRef] [PubMed] [Google Scholar]
  34. Shibutani ST, Saitoh T, Nowag H, et al. Autophagy and autophagy-related proteins in the immune system. Nat Immunol 2015 ; 16 : 1014–1024. [CrossRef] [PubMed] [Google Scholar]
  35. Blander JM, Medzhitov R. Regulation of phagosome maturation by signals from toll-like receptors. Science 2004 ; 304 : 1014–1018. [CrossRef] [PubMed] [Google Scholar]
  36. Delamarre L, Couture R, Mellman I, Trombetta ES. Enhancing immunogenicity by limiting susceptibility to lysosomal proteolysis. J Exp Med 2006 ; 203 : 2049–2055. [CrossRef] [PubMed] [Google Scholar]
  37. Moffat JM, Mintern JD, Villadangos JA. Control of MHC II antigen presentation by ubiquitination. Curr Opin Immunol 2013 ; 25 : 109–114. [CrossRef] [PubMed] [Google Scholar]
  38. Cho KJ, Roche PA. Regulation of MHC Class II-Peptide Complex Expression by Ubiquitination. Front Immunol 2013 ; 4 : 369. [PubMed] [Google Scholar]
  39. Martinez J, Almendinger J, Oberst A, et al. Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells. Proc Natl Acad Sci USA 2011 ; 108 : 17396–17401. [CrossRef] [Google Scholar]
  40. Romao S, Gasser N, Becker AC, et al. Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing. J Cell Biol 2013 ; 203 : 757–766. [CrossRef] [PubMed] [Google Scholar]
  41. Martinez J, Cunha LD, Park S, et al. Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells. Nature 2016 ; 533 : 115–119. [CrossRef] [PubMed] [Google Scholar]
  42. Majai G, Kiss E, Tarr T, et al. Decreased apopto-phagocytic gene expression in the macrophages of systemic lupus erythematosus patients. Lupus 2014 ; 23 : 133–145. [CrossRef] [PubMed] [Google Scholar]
  43. Page N, Gros F, Schall N, et al. HSC70 blockade by the therapeutic peptide P140 affects autophagic processes and endogenous MHCII presentation in murine lupus. Ann Rheum Dis 2011 ; 70 : 837–843. [CrossRef] [PubMed] [Google Scholar]
  44. Renna M, Jimenez-Sanchez M, Sarkar S, Rubinsztein DC. Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. J Biol Chem 2010 ; 285 : 11061–11067. [CrossRef] [PubMed] [Google Scholar]
  45. Fleming A, Noda T, Yoshimori T, Rubinsztein DC. Chemical modulators of autophagy as biological probes and potential therapeutics. Nat Chem Biol 2011 ; 7 : 9–17. [CrossRef] [PubMed] [Google Scholar]
  46. Levine B, Packer M, Codogno P. Development of autophagy inducers in clinical medicine. J Clin Invest 2015 ; 125 : 14–24. [CrossRef] [PubMed] [Google Scholar]
  47. Rubinsztein DC, Bento CF, Deretic V. Therapeutic targeting of autophagy in neurodegenerative and infectious diseases. J Exp Med 2015 ; 212 : 979–990. [CrossRef] [PubMed] [Google Scholar]
  48. Monneaux F, Lozano JM, Patarroyo ME, et al. T cell recognition and therapeutic effects of a phosphorylated synthetic peptide of the 70K snRNP protein administered in MRL/lpr lupus mice. Eur J Immunol 2003 ; 33 : 287–296. [CrossRef] [PubMed] [Google Scholar]
  49. Dieker J, Cisterna B, Monneaux F, et al. Apoptosis changes the phosphorylation status and subcellular localization of the spliceosomal autoantigen U1–70K. Cell Death Diff 2008 ; 15 : 793–804. [CrossRef] [Google Scholar]
  50. Page N, Schall N, Strub JM, et al. The spliceosomal phosphopeptide P140 controls the lupus disease by interacting with the HSC70 protein and via a mechanism mediated by γδ T cells. PloS One 2009 ; 4 : e5273. [CrossRef] [PubMed] [Google Scholar]
  51. Bozzacco L, Yu H, Zebroski HA, et al. Mass spectrometry analysis and quantitation of peptides presented on the MHC II molecules of mouse spleen dendritic cells. J Proteome Res 2011 ; 10 : 5016–5030. [CrossRef] [PubMed] [Google Scholar]
  52. Dengjel J, Høyer-Hansen M, Nielsen MO, et al. Identification of autophagosome-associated proteins and regulators by quantitative proteomic analysis and genetic screens. Mol Cell Proteomics 2012 ; 11 : M111.014035. [CrossRef] [PubMed] [Google Scholar]
  53. Mathew R, Khor S, Hackett SR, et al. Functional role of autophagy-mediated proteome remodeling in cell survival signaling and innate immunity. Mol Cell 2014 ; 55 : 916–930. [CrossRef] [PubMed] [Google Scholar]
  54. Schall N, Wang F, Dali H et al. Chaperone-mediated autophagy down-regulation normalizes the immune responses in lupus. 2017 (en révision). [Google Scholar]
  55. Zimmer R, Scherbarth HR, Rillo OL, et al. Lupuzor/P140 peptide in patients with systemic lupus erythematosus : a randomised, double-blind, placebo-controlled phase IIb clinical trial. Ann Rheum Dis 2013 ; 72 : 1830–1835. [CrossRef] [PubMed] [Google Scholar]
  56. Sarkar S, Davies JE, Huang Z, et al. Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J Biol Chem 2007 ; 282 : 5641–5652. [CrossRef] [PubMed] [Google Scholar]
  57. Mardones P, Rubinsztein DC, Hetz C. Mystery solved : Trehalose kickstarts autophagy by blocking glucose transport. Sci Signal 2016 ; 9 : fs2. [CrossRef] [PubMed] [Google Scholar]
  58. Muller S, Wallace DJ. The importance of implementing proper selection of excipients in lupus clinical trials. Lupus 2014 ; 23 : 609–614. [CrossRef] [PubMed] [Google Scholar]
  59. Schall N, Muller S. Resetting the autoreactive immune system with a therapeutic peptide in lupus. Lupus 2015 ; 24 : 412–418. [CrossRef] [PubMed] [Google Scholar]
  60. Dragin N, Le Panse R, Berrih-Aknin S. Predisposition aux pathologies auto-immunes : les hommes ne manquent pas d'Aire. Med Sci (Paris) 2017 ; 33 : 169–175. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]

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