Free Access
Med Sci (Paris)
Volume 32, Number 2, Février 2016
Page(s) 152 - 155
Section Nouvelles
Published online 02 March 2016
  1. Arrowsmith J, Miller P. Trial watch: phase II and phase III attrition rates 2011–2012. Nat Rev Drug Discov 2013 ; 12 : 569. [CrossRef] [PubMed] [Google Scholar]
  2. Latremoliere A, Latini A, Andrews N, et al. Reduction of neuropathic and inflammatory pain through inhibition of the tetrahydrobiopterin pathway. Neuron 2015 ; 86 : 1393–1406. [CrossRef] [PubMed] [Google Scholar]
  3. Tegeder I, Costigan M, Griffin RS, et al. GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med 2006 ; 12 : 1269–1277. [CrossRef] [PubMed] [Google Scholar]
  4. Costigan M, Latremoliere A, Woolf CJ. Analgesia by inhibiting tetrahydrobiopterin synthesis. Curr Opin Pharmacol 2012 ; 12 : 92–99. [CrossRef] [PubMed] [Google Scholar]
  5. Latremoliere A, Costigan M. GCH1, BH4 and pain. Curr Pharm Biotechnol 2011 ; 12 : 1728–1741. [CrossRef] [PubMed] [Google Scholar]
  6. Dugué GP, Tricoire L. Principes et applications de l’optogénétique en neuroscience. Med Sci (Paris) 2015 ; 31 : 291–303. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
  7. Smith GK, Duch DS, Edelstein MP, Bigham EC. New inhibitors of sepiapterin reductase. Lack of an effect of intracellular tetrahydrobiopterin depletion upon in vitro proliferation of two human cell lines. J Biol Chem 1992 ; 267 : 5599–5607. [PubMed] [Google Scholar]
  8. Bonafé L, Thöny B, Penzien JM, et al. Mutations in the sepiapterin reductase gene cause a novel tetrahydrobiopterin-dependent monoamine-neurotransmitter deficiency without hyperphenylalaninemia. Am J Hum Genet 2001 ; 69 : 269–277. [CrossRef] [PubMed] [Google Scholar]
  9. Hirakawa H, Sawada H, Yamahama Y, et al. Expression analysis of the aldo-keto reductases involved in the novel biosynthetic pathway of tetrahydrobiopterin in human and mouse tissues. J Biochem 2009 ; 146 : 51–60. [CrossRef] [PubMed] [Google Scholar]
  10. Milstien S, Kaufman S. The biosynthesis of tetrahydrobiopterin in rat brain. Purification and characterization of 6-pyruvoyl tetrahydropterin (2’-oxo)reductase. J Biol Chem 1989 ; 264 : 8066–8073. [PubMed] [Google Scholar]
  11. Nichol CA, Lee CL, Edelstein MP, et al. Biosynthesis of tetrahydrobiopterin by de novo and salvage pathways in adrenal medulla extracts, mammalian cell cultures, and rat brain in vivo. Proc Natl Acad Sci USA 1983 ; 80 : 1546–1550. [CrossRef] [Google Scholar]

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.