Free Access
Med Sci (Paris)
Volume 25, Number 4, Avril 2009
Page(s) 371 - 376
Section M/S revues
Published online 15 April 2009
  1. Kenyon C, Chang J, Gensch E, et al. A C. elegans mutant that lives twice as long as wild-type. Nature 1993; 366 : 461–4. [Google Scholar]
  2. Kenyon C. A conserved regulatory system for aging. Cell 2001; 105 : 165–8. [Google Scholar]
  3. Tatar M, Kopelman A, Epstein D, et al. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 2001; 292 : 107–10. [Google Scholar]
  4. Giannakou ME, Partridge L. Role of insulin-like signalling in Drosophila lifespan. Trends Biochem Sci 2007; 32 : 180–8. [Google Scholar]
  5. Coschigano KT, Clemmons D, Bellushi LL, Kopchick JJ. Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. Endocrinology 2000; 141 : 2608–13. [Google Scholar]
  6. Coschigano KT, Holland AN, Riders ME, et al. Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. Endocrinology 2003; 144 : 3799–810. [Google Scholar]
  7. Godfrey P, Rahal JO, Beamer WG, et al. GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function. Nat Genet 1993; 4 : 227–32. [Google Scholar]
  8. Flurkey K, Papaconstantinou J, Miller RA, Harrison DE. Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc Natl Acad Sci USA 2001; 98 : 6736–41. [Google Scholar]
  9. Flurkey K, Papaconstantinou J, Miller RA, Harrison DE. Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc Natl Acad Sci USA 2001; 98 : 6736–41. [Google Scholar]
  10. Brown-Borg HM, Borg KE, Meliska CJ, Bartke A. Dwarf mice and the ageing process. Nature 1996; 384 : 33. [Google Scholar]
  11. Holzenberger M, Dupont J, Ducos B, et al. IGF-1 receptor regulates life span and resistance to oxidative stress in mice. Nature 2003; 421 : 182–7. [Google Scholar]
  12. Selman C, Lingard S, Choudhury AI, et al. Evidence for lifespan extension and delayed agerelated biomarkers in insulin receptor substrate 1 null mice. FASEB J 2008; 22 : 807–18. [Google Scholar]
  13. Migliaccio E, Giorgio M, Mele S, et al. The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 1999; 402 : 309–13. [Google Scholar]
  14. Kappeler L, De Magalhaes Filho C, Dupont J, et al. Brain insulin-like growth factor receptors determine mammalian growth and lifespan. PLoS Biol 2008; 6 : 2144–53. [Google Scholar]
  15. Apfeld J, Kenyon C. Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and lifespan. Cell 1998; 95 : 199–210. [Google Scholar]
  16. Wolkow CA, Kimura KD, Lee MS, Ruvkun G. Regulation of C. elegans life-span by insulin like signaling in the nervous system. Science 2000; 290 : 147–50. [Google Scholar]
  17. Apfeld J, Kenyon C. Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 1999; 402 : 804–8. [Google Scholar]
  18. Alcedo J, Kenyon C. Regulation of C. elegans longevity by specific gustatory and olfactory neurons. Neuron 2004; 41 : 45–55. [Google Scholar]
  19. Hwangbo DS, Gershman B, Tu MP, et al. Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 2004; 429 : 562–6. [Google Scholar]
  20. Giannakou ME, Goss M, Junger MA, et al. Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science 2004; 305 : 361. [Google Scholar]
  21. Kappeler L, De Magalhaes Filho C, Leneuve P, et al. Early postnatal nutrition determines somatotropic function in mice. Endocrinology 2009; 150 : 314–23. [Google Scholar]
  22. Thissen JP, Underwood LE, Ketelslegers JM. Regulation of insulin-like growth factor-I in starvation and injury. Nutr Rev 1999; 57 : 167–76. [Google Scholar]
  23. Taguchi A, Wartschow LM, White MF. Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 2007; 317 : 369–72. [Google Scholar]
  24. Sutter NB, Bustamante CD, Chase K, et al. A single IGF1 allele is a major determinant of small size in dogs. Science 2007; 316 : 112–5. [Google Scholar]
  25. Patronek GJ, Waters DJ, Glickman LT. Comparative longevity of pet dogs and humans: implications for gerontology research. J Gerontol 1997; 52 : B171–8. [Google Scholar]
  26. Bonafé M, Barbieri M, Marchegiani F, et al. Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control. J Clin Endocrinol Metab 2003; 88 : 3299–104. [Google Scholar]
  27. Van Heemst D, Beekman M, Mooijaart SP, et al. Reduced insulin/IGF-1 signalling and human longevity. Aging Cell 2005; 4 : 79–85. [Google Scholar]
  28. Suh Y, Atzmon G, Cho MO, et al. Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proc Natl Acad Sci USA 2008; 105 : 3438–42. [Google Scholar]
  29. Kauppinen-Makelin R, Sane T, Reunanen A, et al. A nationwide survey of mortality in acromegaly. J Clin Endocrinol Metab 2005; 90 : 4081–6. [Google Scholar]
  30. Raynaud-Simon A, Lafont S, Berr C, et al. Plasma insulin-like growth factor I levels in the elderly: relation to plasma dehydroepiandrosterone sulfate levels, nutritional status, health and mortality. Gerontology 2001; 47 : 198–206. [Google Scholar]
  31. Kappeler L, De Magalhaes Filho C, Le Bouc Y, Holzenberger M. Durée de vie, génétique et axe somatotrope. Med Sci (Paris) 2006; 22 : 259–65. [Google Scholar]
  32. Gilgenkrantz S. Un allèle IGF1 pour les petits chiens. Med Sci (Paris) 2007; 23 : 556–8. [Google Scholar]
  33. Pulichino AM, Vallette-Kasic S, Couture C, Brue T, Drouin J. Mutations du facteur de transcription Tpit et différenciation hypophysaire. Med Sci (Paris) 2004; 20 : 1009–13. [Google Scholar]

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