Free Access
Med Sci (Paris)
Volume 25, Number 4, Avril 2009
Page(s) 341 - 343
Section Nouvelles
Published online 15 April 2009
  1. Spolski R, Leonard WJ. Interleukin-21 : basic biology and implications for cancer and autoimmunity. Ann Rev Immunol 2008; 26 : 57–79. [Google Scholar]
  2. Gougelet A, Mansuy A, Blay J. De l’eau au moulin de thérapies ciblant l’interleukine-6 dans les tumeurs épithéliales. Med Sci (Paris) 2008; 24 : 694–6. [Google Scholar]
  3. Kirkwood JM, Tarhini AA, Panelli MC, et al. Next generation of immunotherapy for melanoma. J Clin Oncol 2008; 26 : 3445–55. [Google Scholar]
  4. Andorsky DJ, Timmerman JM. Interleukin-21 : biology and application to cancer therapy. Exp Opin Biol Ther 2008; 8 : 1295–307. [Google Scholar]
  5. Comes A, Rosso O, Orengo AM, et al. CD25+ regulatory T cell depletion augments immunotherapy of micrometastases by an IL-21-secreting cellular vaccine. J Immunol 2006; 176 : 1750–8. [Google Scholar]
  6. Zeng R, Spolski R, Finkelstein SE, et al. Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function. J Exp Med 2005; 201 : 139–48. [Google Scholar]
  7. Wang G, Tschoi M, Spolski R, et al. In vivo antitumor activity of interleukin 21 mediated by natural killer cells. Cancer Res 2003; 63 : 9016–22. [Google Scholar]
  8. Moroz A, Eppolito C, Li Q, et al. IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity : Comparative evaluation of IL-2, IL-15, and IL-21. J Immunol 2004; 173 : 900–9. [Google Scholar]
  9. Skak K, Kragh M, Hausman D, et al. Interleukin 21 : combination strategies for cancer therapy. Nat Rev Drug Discov 2008; 7 : 231–40. [Google Scholar]
  10. Roda JM, Joshi T, Butchar JP, et al. The activation of natural killer cell effector functions by cetuximab-coated, epidermal growth factor receptor positive tumor cells is enhanced by cytokines. Clin Cancer Res 2007; 13 : 6419–28. [Google Scholar]
  11. Gowda A, Roda J, Hussain SRA, et al. IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibodydependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro. Blood 2008; 111 : 4723–30. [Google Scholar]
  12. Akamatsu N, Yamada Y, Hasegawa H, et al. High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma. Cancer Lett 2007; 256 : 196–206. [Google Scholar]
  13. Sarosiek K, Chen J, Pham DG, et al. Interleukin-21-induced apoptosis and cell death of diffuse large-B cell lymphoma (DLBCL) cell lines and primary tumors are associated with an induction of Bim. ASH Annual Meeting. Blood 2006; 108 (suppl) : 2503 (abstract). [Google Scholar]
  14. Marzec M, Halasa K, Kasprzycka M, et al. Differential effects of interleukin-2 and interleukin-15 versus interleukin-21 on CD4+ cutaneous T-cell lymphoma cells. Cancer Res 2008; 68 : 1083–91. [Google Scholar]
  15. Yoon J, Newton S, Wysocka M, et al. IL-21 enhances antitumor responses without stimulating proliferation of malignant T cells of patients with Sézary syndrome. J Invest Dermatol 2008; 128 : 473–80. [Google Scholar]
  16. Iannello A, Tremblay C, Routy J, et al. Decreased levels of circulating IL-21 in HIV-infected AIDS patients : Correlation with CD4+ T cell counts. Viral Immunol 2008; 21 : 385–8. [Google Scholar]

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