Free Access
Med Sci (Paris)
Volume 20, Number 10, Octobre 2004
Page(s) 899 - 903
Section M/S revues
Published online 15 October 2004
  1. Rosso S, Zanetti R, Martinez C, et al. The multicentre south European study « Helios ». II. Different sun exposure patterns in the aetiology of basal cell and squamous cell carcinomas of the skin. Br J Cancer 1996; 73 : 1447–54. [Google Scholar]
  2. Hahn H, Wicking C, Zaphiropoulous PG, et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 1996; 85 : 841–51. [Google Scholar]
  3. Johnson RL, Rothman AL, Xie J, et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 1996; 272 : 1668–71. [Google Scholar]
  4. Quinn AG, Sikkink S, Rees J. Delineation of two distinct deleted regions on chromosome 9 in human non-melanoma skin cancers. Genes Chrom Cancer 1994; 11 : 222–5. [Google Scholar]
  5. Jin Y, Martins C, Salemark L, et al. Nonrandom karyotypic features in basal cell carcinomas of the skin. Cancer Genet Cytogenet 2001; 131 : 109–19. [Google Scholar]
  6. Basset-Seguin N, Moles JP, Mils V, et al. TP53 tumor suppressor gene and skin carcinogenesis. J Invest Dermatol 1994; 103 : S102–6. [Google Scholar]
  7. Matsumura Y, Nishigori C, Yagi T, et al. Characterization of p53 gene mutations in basal-cell carcinomas: Comparison between sun-exposed and less-exposed skin areas. Int J Cancer 1996; 65 : 778–80. [Google Scholar]
  8. Bale AE, Yu KP. The Hedgehog pathway and basal cell carcinomas. Hum Mol Genet 2001; 10 : 757–62. [Google Scholar]
  9. Smyth I, Narang MA, Evans T, et al. Isolation and characterization of human Patched 2 (PTCH2), a putative tumour suppressor gene, in basal cell carcinoma and medulloblastoma on chromosome 1p32. Hum Mol Genet 1999; 8 : 291–7. [Google Scholar]
  10. Gemmill RM, West JD, Boldog F, et al. The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a Patched-related gene, TRC8. Proc Natl Acad Sci USA 1998; 95 : 9572–7. [Google Scholar]
  11. Van den Heuvel M, Ingham PW. Smoothened encodes a receptor-like serpentine protein required for Hedgehog signalling. Nature 1996; 382 : 547–51. [Google Scholar]
  12. Incardona JP, Lee JH, Robertson CP, et al. Receptor-mediated endocytosis of soluble and membrane-tethered Sonic Hedgehog by Patched-1. Proc Natl Acad Sci USA 2000; 97 : 12044–9. [Google Scholar]
  13. Denef N, Neubuser D, Perez L, Cohen SM. Hedgehog induces opposite changes in turnover and subcellular localization of Patched and Smoothened. Cell 2000; 102 : 521–31. [Google Scholar]
  14. Taipale J, Cooper MK, Maiti T, Beachy PA. Patched acts catalytically to suppress the activity of Smoothened. Nature 2002; 418 : 892–7. [Google Scholar]
  15. Farndon PA, Del Mastro RG, Evans DG, Kilpatrick MW. Location of gene for Gorlin syndrome. Lancet 1992; 339 : 581–2. [Google Scholar]
  16. Kimonis VE, Goldsetin AM, Pastakia B, et al. Clinical manifestation in 105 persons with nevoid basal cell carcinoma syndrome. Am J Med Genet 1997; 69 : 299–308. [Google Scholar]
  17. Toftgard R. Hedgehog signalling in cancer. Cell Mol Life Sci 2000; 57 : 1720–31. [Google Scholar]
  18. Gailani MR, Stahle-Backdahl M, Leffell DJ, et al. The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas. Nat Genet 1996; 14 : 78–81. [Google Scholar]
  19. Aszterbaum M, Rothman A, Johnson RL, et al. Identification of mutations in the human Patched gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndrome. J Invest Dermatol 1998; 110 : 885–8. [Google Scholar]
  20. Unden AB, Holmberg E, Lundh-Rozell B, et al. Mutations in the human homologue of Drosophila patched (PTCH) in basal cell carcinomas and the Gorlin syndrome: different in vivo mechanisms of PTCH inactivation. Cancer Res 1996; 56 : 4562–5. [Google Scholar]
  21. Ling G, Ahmadian A, Persson A, et al. Patched and p53 gene alterations in sporadic and hereditary basal cell cancer. Oncogene 2001; 20 : 7770–8. [Google Scholar]
  22. Xie J, Murone M, Luoh SM, et al. Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature 1998; 391 ; 90–2. [Google Scholar]
  23. Oro AE, Higgins KM, Hu Z, et al. Basal cell carcinomas in mice overexpressing Sonic Hedgehog. Science 1997; 276 : 817–21. [Google Scholar]
  24. Wicking C, Evans T, Henk B, et al. No evidence for the H133Y mutation in Sonic Hedgehog in a collection of common tumour types. Oncogene 1998; 16 : 1091–3. [Google Scholar]
  25. Xie J, Aszterbaum M, Zhang X, et al. A role of PDGFRalpha in basal cell carcinoma proliferation. Proc Natl Acad Sci USA 2001; 98 : 9255–9. [Google Scholar]
  26. Kaufman E, Knochel W. Five years on the wings of fork head. Mech Dev 2001; 57 : 3–20. [Google Scholar]
  27. Teh MT, Wong ST, Neill GW, et al. FOXM1 is a downstream target of Gli1 in basal cell carcinomas. Cancer Res 2002; 62 : 4773–80. [Google Scholar]
  28. Fan H, Oro AE, Scott MP, Khavari PA. Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog. Nat Med 1997; 3 : 788–92. [Google Scholar]
  29. Hahn H, Wojnowski L, Zimmer AM, et al. Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome. Nat Med 1198; 4 : 619–22. [Google Scholar]
  30. Aszterbaum M, Epstein J, Oro A, et al. Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice. Nat Med 1999; 5 : 1285–91. [Google Scholar]
  31. Grachtchouk M, Mo R, Yu S, et al. Basal cell carcinomas in mice overexpressing Gli2 in skin. Nat Genet 2000; 24 : 216–7. [Google Scholar]
  32. Nilsson M, Unden AB, Krause D, et al. Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1. Proc Natl Acad Sci USA 2000; 97 : 3438–43. [Google Scholar]
  33. Sasaki H, Nishizaki Y, Hui C, et al. Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development 1999; 126 : 3915–24. [Google Scholar]
  34. Keeler RF, Binns W. Teratogenic compounds of Veratrum californicum (Durand). V. Comparison of cyclopian effects of steroidal alkaloids from the plant and structurally related compounds from other sources. Teratology 1968; 1 : 5–10. [Google Scholar]
  35. Incardona JP, Gaffield W, Kapur RP, Roelink H. The teratogenic Veratrum alkaloid cyclopamine inhibits Sonic Hedgehog signal transduction. Development 1998; 125 : 3553–62. [Google Scholar]
  36. Taipale J, Chen JK, Cooper MK, et al. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature 2000; 406 : 1005–9. [Google Scholar]
  37. Chen JK, Taipale J, Cooper MK, Beachy PA. Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev 2002; 16 : 2743–8. [Google Scholar]
  38. Berman DM, Karhadkar SS, Hallahan AR, et al. Medulloblastoma growth inhibition by Hedgehog pathway blockade. Science 2002; 297 : 1559–61. [Google Scholar]

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