Free Access
Med Sci (Paris)
Volume 18, Number 5, Mai 2002
Page(s) 610 - 615
Section Le Magazine : Mini-Synthèses
Published online 15 May 2002
  1. Stocker H, Hafen E. Genetic control of cell size. Curr Opin Genet Dev 2000; 10 : 529–35. [Google Scholar]
  2. Weinkove D, Neufeld TP, Twardzik T, Waterfield MD, Leevers SJ. Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phos-phoinositide 3-kinase and its adaptor. Curr Biol 1999; 9 : 1019–29. [Google Scholar]
  3. Lamothe B, Baudry A, Desbois P, et al. Genetic engineering in mice: impact on insulin signalling and action. Biochem J 1998; 335 : 193–204. [Google Scholar]
  4. Takahashi Y, Kadowaki H, Momomura K, et al. A homozygous kinase-defective mutation in the insulin receptor gene in a patient with leprechaunism. Diabetologia 1997; 40 : 412–20. [Google Scholar]
  5. Bohni R, Riesgo-Escovar J, Oldham S, et al. Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4. Cell 1999; 97 : 865–75. [Google Scholar]
  6. Brogiolo W, Stocker H, Ikeya T, Rintelen F, Fernandez R, Hafen E. An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr Biol 2001; 11 : 213–21. [Google Scholar]
  7. Abe H, Yamada N, Kamata K, et al. Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1. J Clin Invest 1998; 101 : 1784–8. [Google Scholar]
  8. Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 1997; 277 : 942–6. [Google Scholar]
  9. Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature 1993; 366 : 461–4. [Google Scholar]
  10. Guarente L, Kenyon C. Genetic pathways that regulate ageing in model organisms. Nature 2000; 408 : 255–62. [Google Scholar]
  11. Kops GJ, de Ruiter ND, De Vries-Smits AM, Powell DR, Bos JL, Burgering BM. Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature 1999; 398 : 630–4. [Google Scholar]
  12. Brunet A, Bonni A, Zigmond MJ, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999; 96 : 857–68. [Google Scholar]
  13. Clancy DJ, Gems D, Harshman LG, et al. Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 2001; 292 : 104–6. [Google Scholar]
  14. Tatar M, Kopelman A, Epstein D, Tu MP, Yin CM, Garofalo RS. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 2001; 292 : 107–10. [Google Scholar]
  15. Bartke A, Brown-Borg H, Mattison J, Kinney B, Hauck S, Wright C. Prolonged longevity of hypopituitary dwarf mice. Exp Gerontol 2001; 36 : 21–8. [Google Scholar]
  16. Cao C , Brown MR. Localization of an insulinlike peptide in brains of two flies. Cell Tissue Res 2001; 304 : 317–21. [Google Scholar]
  17. Masumura M, Satake S, Saegusa H, Mizoguchi A. Glucose stimulates the release of bombyxin, an insulin-related peptide of the silkworm Bombyx mori. Gen Comp Endocrinol 2000; 118 : 393–9. [Google Scholar]
  18. Pierce SB, Costa M, Wisotzkey R, et al. Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev 2001; 15 : 672–86. [Google Scholar]
  19. Bargmann CI , Horvitz HR. Control of larval development by chemosensory neurons in Caenorhabditis elegans. Science 1991; 251 : 1243–6. [Google Scholar]

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