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Filaggrin knock-down in NHEKs affects MAPK signaling pathways. A. Expression of p-Akt, p-NF-kB, p-p38, p-ERK and p-JNK detected by Western blotting after shRNA1 transfection into NHEKs. B. Semi-quantitative analysis of p-Akt, p-NF-kB, p-p38, p-ERK and p-JNK, compared to the control group (NC). n=3, ** P<0.001.
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