Figure 3.
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La dégénérescence discale. A. Représentation schématique de l’évolution des composants du DIV au cours de la dégénérescence discale. B. Vue macroscopique d’un DIV sain (hautement hydraté). C. Vue macroscopique d’un DIV dégénéré (déshydraté et fibrotique). MEC : matrice extracellulaire ; DIV : disque intervertébral ; NGF : nerve growth factor ; VEGF : vascular endothelial growth factor ; TGF-β : transforming growth factor-b ; BMP2 : bone morphogenic protein 2 ; TIMP1-2 : tissue inhibitor of metalloproteinase 1 and 2 ; MMP : matrix metalloproteinase ; ADAMTS : a disintegrin and metalloproteinase with thrombospondin motifs ; IL1-β : interleukine 1-β.
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