Figure 1.
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Monoclonal antibody mechanisms of action in cancer. Blockade of adhesion molecules such as EpCAM, involved in tumor cell migration and metastases, is not represented. ADCC: antibody-dependent cell cytotoxicity; C3bR: receptor for the C3b complement fragment; CDC: complement-dependent cell cytotoxicity; CTLs: cytotoxic T cells; DCs: dendritic cells; FcγR: receptors for the Fc region of IgG; Th: helper T cells.
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