Figure 1.

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Récepteurs intracellulaires du système immunitaire inné.Les Nod-like receptors (NLR) font partie de la famille des récepteurs intracellulaires de l’immunité innée. La famille des NLR comprend 22 membres dont les NALP (NACHT, LRR and PYD containing protein), les NOD (nucleotide oligomerisation domain), IPAF (ICE protease activating factor), NAIP (neuronal apoptosis inhibitory protein) et le facteur de transcription CIITA. Chaque sous-famille active des voies de signalisation différentes. LRR : leucine-rich repeat ; NAD : NACHT associated domain ; NACHT : domain present in neuronal apoptosis inhibitory protein (NAIP), the major histocompatibility complex (MHC) class II transactivator (CIITA), HET-E and TP1 ; PYD : Pyrin domain ; CARD : caspase recruitment domain ; BIR : baculovirus inhibitor of apoptosis (IAP) repeat.
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