| Issue |
Med Sci (Paris)
Volume 38, Number 10, Octobre 2022
|
|
|---|---|---|
| Page(s) | 839 - 841 | |
| Section | Forum | |
| DOI | https://doi.org/10.1051/medsci/2022126 | |
| Published online | 11 October 2022 | |
Scoop : les mutations « synonymes » ne sont pas neutres !
Chroniques génomiques
Silent - but not neutral!
Biologiste, généticien et immunologiste, président d’Aprogène (Association pour la promotion de la génomique), 13007 Marseille, France
Abstract
An ingenious system for generating thousands of point mutations in yeast genes and measuring their effect on fitness shows convincingly that, for the chosen subset of representative non-essential genes, silent mutations have as much effect on fitness as missense mutations. In other words, silent mutations are not neutral, at least under these conditions. This result has important implications for evolutionary biology.
© 2022 médecine/sciences – Inserm
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