| Issue |
Med Sci (Paris)
Volume 38, Number 4, Avril 2022
|
|
|---|---|---|
| Page(s) | 398 - 400 | |
| Section | Forum | |
| DOI | https://doi.org/10.1051/medsci/2022032 | |
| Published online | 29 April 2022 | |
Chiens, loups et gènes
Chroniques génomiques
Dogs, wolves and genes
Biologiste, généticien et immunologiste, président d’Aprogène (Association pour la promotion de la génomique), 13007 Marseille, France
Abstract
The most significant polymorphism associated with dog size occurs in the region of the IGF1 gene and concerns a single base change in a neighbouring lncRNA. The “small” (C) allele of this SNP is mostly found in small modern breeds and canids (foxes, coyotes, jackals) while the “large” (T) dominates in wolves and large dogs. However, the small allele is also present at low level in ancient wolves and is shown to represent the ancestral allele in canids, which has been recently selected in small dog breeds obtained by human selection.
© 2022 médecine/sciences – Inserm
Article publié sous les conditions définies par la licence Creative Commons Attribution License CC-BY (https://creativecommons.org/licenses/by/4.0), qui autorise sans restrictions l'utilisation, la diffusion, et la reproduction sur quelque support que ce soit, sous réserve de citation correcte de la publication originale.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.