| Issue |
Med Sci (Paris)
Volume 38, Number 3, Mars 2022
|
|
|---|---|---|
| Page(s) | 317 - 319 | |
| Section | Forum | |
| DOI | https://doi.org/10.1051/medsci/2022019 | |
| Published online | 25 March 2022 | |
Réparation de l’ADN et longévité : les rongeurs et nous
Chroniques génomiques
DNA repair and longevity in mice, other rodents and men
Biologiste, généticien et immunologiste, président d’Aprogène (Association pour la promotion de la Génomique), 13007 Marseille, France
Abstract
Large differences in maximum longevity exist between different rodent species. Determination of the spontaneous and mutagen-induced mutation rates in these species by single (somatic) cell sequencing suggests more efficient DNA repair in long-lived species (including humans), but the data is too noisy to prove a strong correlation between longevity and preservation of DNA integrity.
© 2022 médecine/sciences – Inserm
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