| Issue |
Med Sci (Paris)
Volume 38, Number 1, Janvier 2022
|
|
|---|---|---|
| Page(s) | 101 - 106 | |
| Section | Forum | |
| DOI | https://doi.org/10.1051/medsci/2021239 | |
| Published online | 21 January 2022 | |
Ces bons mutants qui éliminent les tumeurs
Chroniques génomiques
Good mutant clones eliminate nascent tumours
ADÉS (Anthropologie bioculturelle, droit, éthique et santé) UMR CNRS 7268, Aix Marseille université, Établissement français du sang. CoReBio PACA, case 901, Parc scientifique de Luminy, 13288 Marseille Cedex 09, France
Abstract
Most (>90%) of the nascent tumours present in murine oesophageal epithelium after mutagen treatment disappear during the following months. This elimination is driven by mutant (but phenotypically normal) clones that gradually outcompete and eliminate the neoplastic clones. This novel mechanism, demonstrated in the mouse, is probably active in humans as well and may have important clinical implications.
© 2022 médecine/sciences – Inserm
Article publié sous les conditions définies par la licence Creative Commons Attribution License CC-BY (https://creativecommons.org/licenses/by/4.0), qui autorise sans restrictions l'utilisation, la diffusion, et la reproduction sur quelque support que ce soit, sous réserve de citation correcte de la publication originale.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.