| Issue |
Med Sci (Paris)
Volume 37, Number 11, Novembre 2021
|
|
|---|---|---|
| Page(s) | 1062 - 1065 | |
| Section | Forum | |
| DOI | https://doi.org/10.1051/medsci/2021161 | |
| Published online | 01 December 2021 | |
Les sénolytiques contre la Covid-19 ?
Chroniques génomiques
Senolytics against Covid-19?
ADÉS (Anthropologie bioculturelle, droit, éthique et santé) UMR CNRS 7268, Aix Marseille université, Établissement français du sang. CoReBio PACA, case 901, Parc scientifique de Luminy, 13288 Marseille Cedex 09, France
Abstract
The elimination of some senescent cells by « senolytic » compounds can greatly improve the health of aged mice and in some cases reverse the effects of aging. Using a microbial exposure system that closely models coronavirus infection, it is possible to largely protect old mice from the effects of viral infection. This immediately suggests clinical application of the approach, and is the aim of ongoing phase II clinical trials in Covid-19 patients.
© 2021 médecine/sciences – Inserm
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