| Issue |
Med Sci (Paris)
Volume 36, Number 6-7, Juin–Juillet 2020
|
|
|---|---|---|
| Page(s) | 675 - 677 | |
| Section | Forum | |
| DOI | https://doi.org/10.1051/medsci/2020108 | |
| Published online | 02 July 2020 | |
Chroniques génomiques
Le Junk DNA n’est plus ce qu’il était
Junk DNA is out of fashion
UMR 7268 ADÉS, Aix-Marseille, Université /EFS/CNRS ; CoReBio PACA, case 901, Parc scientifique de Luminy, 13288 Marseille Cedex 09, France
Abstract
A systematic search for non-conventional open reading frames in human DNA reveals a large number of small ORFs encoding peptides generally smaller than 100 amino-acids. These ORFs are transcribed and translated into small proteins, which are demonstrated to have functional significance by bulk CRISPR inactivation. Evidence is also found for bicistronic mRNAs including such a small ORF upstream of a canonical coding sequence. These findings add a new facet to our understanding of biological processes.
© 2020 médecine/sciences – Inserm
Article publié sous les conditions définies par la licence Creative Commons Attribution License CC-BY (https://creativecommons.org/licenses/by/4.0), qui autorise sans restrictions l'utilisation, la diffusion, et la reproduction sur quelque support que ce soit, sous réserve de citation correcte de la publication originale.
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