Med Sci (Paris)
Volume 35, Number 2, Février 2019
|Page(s)||187 - 190|
|Published online||18 February 2019|
Le monde caché des clones mutants dans les tissus normaux
Hidden pre-cancer clones in normal tissue
UMR 7268 ADÉS, Aix-Marseille, Université/EFS/CNRS ; CoReBio PACA, case 901, Parc scientifique de Luminy, 13288 Marseille Cedex 09, France
Careful sequencing studies on small samples of normal oesophageal epithelium reveal the presence of very abundant cellular clones harbouring mutations in known cancer genes (and elsewhere). The number and size of these clones increases with age. This surprising finding confirms previous studies on sun-exposed epidermis. It has important implications for the understanding of cancer initiation and will hopefully lead to conceptual and clinical advances.
© 2019 médecine/sciences – Inserm
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