| Issue |
Med Sci (Paris)
Volume 35, Number 2, Février 2019
|
|
|---|---|---|
| Page(s) | 187 - 190 | |
| Section | Forum | |
| DOI | https://doi.org/10.1051/medsci/2019010 | |
| Published online | 18 February 2019 | |
Le monde caché des clones mutants dans les tissus normaux
Chroniques génomiques
Hidden pre-cancer clones in normal tissue
UMR 7268 ADÉS, Aix-Marseille, Université/EFS/CNRS ; CoReBio PACA, case 901, Parc scientifique de Luminy, 13288 Marseille Cedex 09, France
Abstract
Careful sequencing studies on small samples of normal oesophageal epithelium reveal the presence of very abundant cellular clones harbouring mutations in known cancer genes (and elsewhere). The number and size of these clones increases with age. This surprising finding confirms previous studies on sun-exposed epidermis. It has important implications for the understanding of cancer initiation and will hopefully lead to conceptual and clinical advances.
© 2019 médecine/sciences – Inserm
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.