Med Sci (Paris)
Volume 34, Number 12, Décembre 2018
|Page(s)||1116 - 1122|
|Published online||09 January 2019|
Balayage du génome et repérage des personnes à risque
Des GWAS aux GPS
From genome-wide association studies (gwas) to genome-wide polygenic scores (GPS)
UMR 7268 ADÉS, Aix-Marseille, Université/EFS/CNRS ; CoReBio PACA, case 901, Parc scientifique de Luminy, 13288 Marseille Cedex 09, France
The accumulation of extensive repositories linking phenotypic and genetic information, together with new computation methods, makes it possible to derive polygenic scores for susceptibility to common diseases that turn out to have strong predictive power. These will be clinically useful to identify individuals at high risk who may be eligible for protective interventions.
© 2018 médecine/sciences – Inserm
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