Med Sci (Paris)
Volume 34, October 2018Cancer biomarkers
|Page(s)||15 - 19|
|Published online||07 November 2018|
Gastric carcinoma with a gastrointestinal stromal tumor
A case report and literature review
Department of Gastrointestinal Surgery, Tianjin 4th Central Hospital, Hebei District, Tianjin 300140, China
2 Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute
3 Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Heping District, Tianjin 300052, China
Gastric carcinoma (GC) with gastrointestinal stromal tumor (GIST) is encountered very rarely in the clinic, and few cases have been reported in the literature. Here, we present a case involving a 72-year-old man who was diagnosed with gastric antrum adenocarcinoma accompanied by neuroendocrine differentiation and a GIST in the fundus, according to a preoperative examination and postoperative pathology. The patient then underwent a distal radical gastrectomy and GIST resection. After the operation, the patient was administered combined chemo-radiotherapy and subsequently underwent a 9-month follow-up examination. The gene mutations involved in this case were explored via high-throughput sequencing. The high-throughput gene mutation analysis indicated an exon5 mutation in the TP53 gene and copy number amplification of FGF19, CCND1, and FGFR2 in the gastric antrum adenocarcinoma. A gene sequencing analysis of the gastric fundus stromal tumor demonstrated an exon11 non-frame shift deletion mutation in the KIT gene. These findings suggested that this patient’s cancer might be sensitive to AZD1775 (a TP53-targeted drug) or targeted drugs such as FGF19, CCND1 and FGFR2, and should be sensitive to imatinib.
Key words: Gastric carcinoma (GC) / Gastrointestinal stromal tumor (GIST) / Gene mutation; High-throughput sequencing
© 2018 médecine/sciences – Inserm
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