| Issue |
Med Sci (Paris)
Volume 33, Number 6-7, Juin-Juillet 2017
|
|
|---|---|---|
| Page(s) | 674 - 676 | |
| Section | Forum | |
| DOI | https://doi.org/10.1051/medsci/20173306028 | |
| Published online | 19 July 2017 | |
Variants fréquents et rares, caractères multigéniques et héritabilité perdue
Chroniques génomiques
Common and rare variants, polygenic traits and missing heritability
UMR 7268 ADÉS, Aix-Marseille, Université/EFS/CNRS,Espace éthique méditerranéen, hôpital d’adultes la Timone, 264, rue Saint-Pierre, 13385 Marseille Cedex 05, France ;
CoReBio PACA, case 901, parc scientifique de Luminy, 13288 Marseille Cedex 09, France
*
bertrand.jordan@univ-amu.fr
**
brjordan@orange.fr
Abstract
Recently, a systematic (but limited) search for rare variants implicated in adult height, a highly polygenic trait, has uncovered a number of new variants for which the effect size is inversely correlated with the minor allele frequency. This opens interesting perspectives on the genetic architecture of complex traits and on the vexing problem of “missing heritability”.
© 2017 médecine/sciences – Inserm
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